TEST NAME: Prenatal Microarray
INDICATIONS FOR TESTING:
- Evaluates hundreds of genetic conditions across the genome with one test
- Detects aneuploidy (including trisomy and sex chromosome abnormalities) and triploidy
- Identifies deletions and duplications in regions known to be associated with well-characterized microdeletion and microduplication syndromes
- Provides enriched coverage of subtelomeric regions, often undetectable by traditional chromosome analysis
- More comprehensive than individual FISH tests
- Often allows for results on suboptimal specimens for which chromosome analysis is not feasible
- Cannot identify all genetic conditions or the cause of all fetal anomalies in a pregnancy
- Does not detect changes in the DNA sequence of genes
- Cannot detect balanced chromosome rearrangements (a complementary test such as Prenatal Chromosome Analysis should be performed to detect balanced chromosome rearrangements)
- Unable to reliably detect all cases of mosaicism
- A normal result indicates no clinically-significant chromosome anomalies were identified.
- An abnormal or pathogenic result indicates that a clinically-significant chromosome anomaly was identified in the fetus.
- Our Prenatal Microarray is designed to identify clinically-relevant anomalies. However, in rare cases, a reportable anomaly may be identified for which a definitive classification (i.e., normal or abnormal) is not possible. In those cases, these anomalies will be reported as variants of uncertain clinical significance.
- Parental testing may be recommended in order to clarify whether the result is de novo or familial for the purpose of recurrence risk calculation.
- Prenatal Microarray does NOT analyze the mother’s chromosomes. If desired, Postnatal Chromosome Analysis on maternal blood can be ordered separately.
- Prenatal Microarray can be completed concurrently with Prenatal Chromosome Analysis or as a reflex if chromosome analysis does not identify an abnormality.
REQUIRED FORMS: Prenatal and Pregnancy Loss Test Request Form
OTHER FORMS: Request for Pre-Authorization for Genetic Testing (Prenatal Diagnoses)
- Amniotic Fluid: 10 - 15 ml amniotic fluid in 2 sterile tubes
- PLUS Prenatal FISH: collect an additional 5 ml (15-20 ml total needed to perform Prenatal Microarray and FISH)
- PLUS Prenatal Chromosome Analysis: collect an additional 15-20 ml (25-35 ml total needed to perform Prenatal Microarray and Prenatal Chromosome Analysis)
- Chorionic Villi Sampling (CVS): 10-20 mg in (sterile) villi in tissue culture media
SPECIMEN COLLECTION & SHIPPING
- Amniotic Fluid / CVS / Fetal Fluid: 81229, 88235
PRICING: Contact the laboratory billing staff for current costs.
TURN AROUND TIME: Results are typically available in 1-2 weeks.
LINKS and REFERENCES: