Prenatal Microarray

Test name:  Prenatal Microarray
Also known as: Prenatal Array

Indications:

• Advanced maternal age
• Abnormal ultrasound findings
• Abnormal prenatal screen
• Family history of structural chromosome abnormality or rearrangement
• IUFD 

Test Information:

• A 44K oligo platform is currently used to evaluate a pregnancy for small copy number changes that are undetectable by Prenatal Chromosome Analysis alone
• Approximately 100 known microdeletion/microduplication syndromes are evaluated using this technology in addition to subtelomere regions.
• Balanced chromosome arrangements and low level mosaicism are not detected with this test
• Prenatal Microarray is more comprehensive and cost effective than ordering multiple FISH tests.  
• Prenatal Microarray will not detect single gene mutations; if additional single gene testing is considered for a familial genetic condition or abnormal ultrasound findings, contact a laboratory genetic counselor prior to sending the sample

Specimen requirements:

• Amniotic Fluid: 10-20 ml of amniotic fluid in 2 sterile tubes (total of 20-25 if ordering with Prenatal Chromosome Analysis and Rapid Aneuploidy FISH)
• CVS: 10-15 mg in sterile tissue culture media

CPT codes: 88235, 81229

Pricing: Contact the laboratory billing staff for current costs

Shipping & Handling

Required forms: Prenatal Test Request Form

Turn-around time: Results are typically available in 2 weeks and can be completed concurrently with Prenatal Chromosome Analysis or as a reflex if chromosome analysis does not identify an abnormality

Additional links: Prenatal Microarray Flyer, Amniocentesis brochure in English, Amniocentesis brochure in Spanish, CVS brochure

revised: 3-20-13