Jyothi Arikkath, PhD
Developmental Neuroscience Department
985960 Nebraska Medical Center
Omaha, NE 68198-5960
Office Phone: (402) 559-8461
Lab Phone: (402) 559-8462
Dr. Arikkath is an Assistant professor of Developmental Neuroscience in the Munroe-Meyer Institute for Genetics and Rehabilitation at the University of Nebraska Medical Center. She received her postdoctoral training in molecular and cellular neuroscience at the Howard Hughes Medical Institute at the University of California San Francisco with Dr. Louis Reichardt.
Dr. Arikkath aims to understand the molecular mechanisms that regulate neuronal structure and plasticity and elucidate how these mechanisms influence neural circuit formation and function. It is becoming increasingly clear that aberrant neural circuit formation and /or function underlies the pathology of a number of neurodevelopmental and neurodegenerative disorders. Thus, identifying core components of these pathways would provide better tools for therapeutic intervention in these devastating disorders.
PhD, Molecular Biology, Howard Hughes Medical Institute, University of Iowa
M.Tech, Biomedical Engineering, Indian Institute of Technology, Bombay, India
M.Sc, Microbiology, University of Poona, India
B.Sc, Microbiology, University of Poona, India
Research Interests and Projects:
- Alzheimer’s disease
- Autism Spectrum disorders
- Cri-du-chat syndrome
- Dendrite arborization
- Synaptic development
- Synaptic structure and plasticity
Selected Publications: (within the last 5 years)
- Arikkath, J,(2010), N-cadherin: Stabilizing synapses, Journal of Cell Biology, 189(3), 397-398.
- Arikkath, J,(2009), Spine morphology and plasticity in X-linked mental retardations, The Open Neuroscience Journal, 3, 134-147.
- Arikkath, J,(2009), Regulation of dendrite and spine morphogenesis and plasticity by catenins, Molecular Neurobiology, 40 (1): 46-54.
- Arikkath, J,Peng, I, Ng, YG, Israely, I, Liu, X, Ullian, E.M, Reichardt, LF (2009), d-catenin regulates spine and synapse morphogenesis and function in hippocampal neurons during development, J. Neuroscience, 29(17):5435-42.