Warren G. Sanger, PhD

Warren SangerWarren G. Sanger, PhD
Human Genetics Laboratories
Munroe-Meyer Institute
985440 Nebraska Medical Center
Omaha, NE 68198-5440

Phone: (402) 559-5070
E-mail: wgsanger@unmc.edu

Professional Summary:

Dr. Sanger is the Director of the Human Genetics Laboratories (Cytogenetics and Molecular Cytogenetics Laboratories) and Interim Director of Clinical Genetics at the Munroe-Meyer Institute, University of Nebraska Medical Center in Omaha, Nebraska. He is a Founding Fellow of the American Board of Medical Genetics and is Board Certified as a Clinical Cytogeneticist and Medical Geneticist by the American College of Medical Genetics and American Medical Association.

Dr. Sanger served in the military at the University of Maryland, Far East Division (Seoul, Korea) as a counter intelligence agent and an Instructor in Biology, January 1969 to December 1971. He received his Ph.D. in 1974 and joined the University of Nebraska Medical Center in 1975. Dr. Sanger is a Professor of Pediatrics, Munroe-Meyer Institute and Pathology at the University of Nebraska Medical Center and serves as a Cytogenetics Advisor for several organizations. The Cytogenetics Laboratory provides over 14,000 diagnostic studies and 2,500 research studies per year in the areas of oncology, prenatal health, birth defects, and other molecular genetics projects. Primary research interests are in the areas of cancer genetics, genetic causes of birth defects and developmental disabilities, prenatal diagnosis and prenatal care.

Education:

PhD, University of Nebraska, Lincoln, NE and University of Nebraska Medical Center, Omaha, NE, 1974
MS, University of Nebraska, Lincoln, NE, 1969
BS, Kearney State College, Kearney, NE, 1967
BS, University of Nebraska, Lincoln, NE, 1964

Courses Taught:

Human Genetics 518
Human Cytogenetics Elective
Metabolic Disease and Genetics Elective
Human Genetics 911
Human Cytogenetics 912
Human Cytogenetics Rotations for OB/GYN, Pathology and Pediatrics Residents
Invited Lecturer for graduate courses in Pharmacology, Neurology, Anatomy, Biochemistry, Pathology
and various UNL courses

Research Interests and Projects:

  • Analysis of Post-transplant Lymphoma by cDNA Microarray
  • Childhood B-NHL: Pathological-Immunological-Genetic Study
  • Chronic Myelogenous Leukemia
  • Cytogenetics of Breast and Ovarian Cancer
  • Detection and implications of Occult Tumor Cells in Human Bone Marrow
  • Development of Immune- Therapy for CML
  • Etiological Factors and Mechanisms in Lymphomagenesis
  • Familial Basal Cell Carcinoma Syndromes
  • Gene Expression Analysis by DNA Microarray
  • Genetic Policy
  • Genetics and Birth Defects Service
  • Immunopathology of the X-linked Lymphoproliferative Syndrome
  • Investigation of Chromosome Damage among Farmers and Other Pesticide Applicators
  • Maternal Serum Screening for the Identification of High Risk Pregnancies in Nebraska Education, Coordination and Counseling
  • Molecular Genetics of Genetic Analysis of Fetal Cells From Maternal Circulation
  • Novel Restriction Fragment Polymorphisms and Neoplasia
  • Pancreatic Carcinogenesis
  • Pediatric Hodgkin's Disease
  • Prenatal Screening of Uncultured and Cultured Amniocytes Utilizing Direct Label Probes
  • The Effects of Subfertility on Parent-Child Relation and Child Behavior

Publications: (within the last 5 years)

  • Schaefer, G.B., Starr, L., Pickering, D., Skar, G., DeHaai, K., and Sanger, W.G. Array CGH Findings in a Cohort Referred for an Autism Evaluation. In Press, 2010..
  • Marušiæ, Z., Zovak, M., Hagenkord, J.M., Kash, S., Koul, M.S., Sanger, W.G., Gatalica, A., Krušlin, B., and Tomas, D. Papillary Renal Cell-like Carcinoma in a Retroperitoneal Teratoma. Patholog International, Submitted, 2010.
  • Moreno-de-Luca, D., Kaminsky, E.B., Myers, S.M., Adam, M.P., Pakila, A., Eisenhauer, N.J., Uhas, K., Weik, L., Guy, L., Rossi, M.R., Care, M.E., Morel, C.F., Boni, M., Salbert. B., Pearce, B.D., Chandrareddy, A., Demmer, L.A., Chow, W.C., Surti, U., Hegde, M., Sanger, W.G., Aradhya, S., Martin, C.L., and Ledbetter, D.H. Sex-specific Risk for Autism Associated with Recurrent 17q12 Microdeletion. Nature Genetics. Submitted, 2010.
  • Lim, A.S., Lim, T.H., Tien, S.L., Hess, M.H., Kee, S.K., Lau, Y., Gilbert, R., Hempel, T., Anderson, K., Zaleski, D.H., Chia, P., Raman, S., Tan, H.K., Tan, A, S., Sanger, W.G. Is Rapid Aneuploidy Screening with FISH as a Stand-alone Test Sufficiently Robust in Prenatal Diagnosis? Submitted, 2010.
  • Macferran, K.L., Buchmann, R.F., Ramakrishnaih, R., Griebel, M.L., Sanger, W.G., Saronwala, A., Schaefer, G.B. Pontine Tegmental Cap Dysplasia with a 2q13 Micro-deletion Involving the NPHP1 Gene: Insight into Malformations of the Mid-Hind Brain. Pediatric Neurology, (in press) 2010.
  • Peterson, C., Lester, D.R. and Sanger, W.G. Burkitt’s Lymphoma in Early Pregnancy. Journal of Clinical Oncology Vol 28, 2010.
  • Naushad, H., Choi, W., Page, C.J., Weisenburger, D.D., Sanger, W.G., and Aoun, P. Mantle Cell Lymphoma with Flow Cytometric Evidence of Clonal Plasmacytic Differentiation: A Case Report. Cytometry B Clin Cytom, May; 76(3): 218-224, 2009.
  • Poirel, H.A., Cairo, M.S., Heerema, N., Swansbury, J., Auperin, A., Launay, E., Sanger, W.G., Talley, P., Perkins, S.L., Raphael, M., McCarthy, K., Sposto, R., Gerrard, M., Bernheim, A., and Patte, C. Specific Cytogenetic Abnormalities are Associated with a Significantly Inferior Outcome in Children and Adolescents with Mature B-cell Non-Hodgkin’s Lymphoma: Results of the FAB/LMB 96 International Study. Leukemia 23(2): 323-331, 2009.
  • Gu, K., Fu, K., Jain, S., Liu, Z., Chan, J., Weisenburger, D.D., Greiner, T., Aoun, P., Sanger, W.G., Iqbal, J. , and Dave, B. t(14;18) - Negative Follicular Lymphoma are Associated with a High Frequency of BCL6 Rearrangement at the Alternative Breakpoint Region. Modern Pathol, Sep; 22(9): 1251-1257, 2009.
  • Tsuchiya, K.D., Shaffer, L.G., Aradhya, S., Biggerstaff, J., Gastier-Foster, J., Patel, A., Rudd, M.K., Sanger, W.G., Schwartz, S., Tepperberg J., Thorland, E., Torchia, B., and Brothman, A. Variability in Interpreting & Reporting Copy Number Changes Detected by Array-based Technology in Clinical Laboratories. Genetics in Medicine, 11(12): December 866-873, 2009.
  • Dave, J., Olney, A.H., Zaleski, D., Pickering, D., Becker, T.A., Chipman, H.E., and Sanger, W.G. Inherited 14q Duplication and 21q Deletion: A Rare Adjacent-2 Segregation in Multiple Family Members. Am J Med Genet Part A 149A: 2248-2253, 2009.
  • Nelson, M., Perkins, S., Dave, B., Coccia, P., Bridge, J., Lyden, E., Heerema, N., Lones, M., Harrison, L., Cairo, M., and Sanger, W.G. An Increased Frequency of 13q Deletions Detected by Fluorescence In Situ Hybridization and Its Impact on Survival in Children and Adolescents with Burkitt Lymphoma: Results from the Children’s Oncology Group CCG-5961. British Journal of Haematology 1-11. Doi:10.1111/j.1365-2141, 2009.
  • Dave, B.J., Olney, A.H., Zaleski, D.H., Pickering, D.L., Becker, T.A., Chipman, H.E., and Sanger, W.G. Inherited 14q Duplication and 21q Deletion: A Rare Adjacent-2 Segregation in Multiple Family Members. Am J Med Genet A. Oct 149(10): 2248-2253, 2009.
  • Lones, M.A., Raphael, M., McCarthy, K., Wotherspoon, A., Terrier-Lacombe, M., Ramsay, A.D., MacLennan, K., Cairo, M.S., Gerrard, M., Michon, J., Patte, C., Pinkerton, R., Sender, L., Auperin A., Sposto, R., Weston, C., Heerema, N.A., Sanger, W.G., Bernheim, A., Poirel, H., Swansbury, J., Talley, P., and Perkins, S.L. Primary Follicular Large Cell Lymphoma of the Testis in Children and Adolescents: A Report for CCG-5961. British J. Of Hematology, (In press), 2009.
  • Meehan, D.T., Zink, M.A., Mahien, M., Nelson, M., Sanger, W.G., Mitalipov, S.M., Wolf, D.P., Ouellette, M.M., and Norgren, R.B. Gene Targeting in Adult Rhesus Macaque Fibroblasts. BMC Biotechnology. March, 8:31, 2008.
  • Nelson, M., Horsman, D.E., Weisenburger, D.D., Gascoyne, R.D., Dave, B.J., Loberiza, F.R., Ludkovski, O., Armitage, J.O., and Sanger, W.G. Cytogenetic Abnormalities and Clinical Correlations in Peripheral T-cell Lymphoma. British Journal of Haematol. May, 141(4): 461-469, 2008.
  • Pickering, D.L., Eudy, J.D., Olney, A.H., Dave, B.J., Golden, D., Stevens, J., and Sanger, W.G. Array-CGH Analysis of 1176 Consecutive Clinical Genetics Investigations. Genet in Med, April, 10(4): 262-266, 2008.
  • Young, K.H., Xie, Q., Zhou, G., Eickhogg, J.C., Sanger, W.G., Aoun, P., and Chan, W.C. Transformation of Follicular Lymphoma to Precursor B-cell Lymphoblastic Lymphoma with c-myc Gene Rearrangement as a Critical Event. Am J Clinic Patho, Jan; 129(1): 157-166, 2008.
  • Lynch, H.T., Ferrara, K., Barlogie, B., Coleman, E.A., Lynch, J.F., Weisenburger, D.D., Sanger, W.G., Watson, P., Nipper, H., Witt, V., and Thomé, S. Familial Myeloma: Brief Report. New Engl J Med 359(2): 152-157, 2008.
  • Brandau, D.T., Lund, M., Cooley, L., Sanger, W.G., and Butler, M. Research letter: Autistic and Dysmorphic Features Associated with a Submicroscopic 2q33.3-q34 Interstitial Deletion Detected by Array Comparative Genomic Hybridization. Am J Med Genet, Feb 15, 146A(4): 521-524, 2008.
  • Lau, L.C., Lim, P., Lim, Y.C., Teng, L.M., Lim, L.C., Tan, S.Y., Lim, S.T., Sanger, W.G., and Tien, S.L. Occurrence of Trisomy 12, t(14;18)(q32;q21), and t(8;14)(q24.1;q11.2) in a Patient with B-cell Chronic Lymphocytic Leukemia. Cancer Genet Cytogenet Sep 185(2): 95-101, 2008.
  • Bakshi, S.R., Dave, B.J., Sanger, W.G., Brahmbhatt, M.M., Trivedi, P.J., Kakadia, P.M., and Patel, S.J. Characterization of a Familial Small Supernumerary Marker Chromosome in a Patient with Adult-Onset Tongue Cancer. Cytogenet Genome Res May, 121(1): 14-17, 2008.
  • D’Amore, F., Chan, E., Iqbal, J., Geng, H., Young, K., Li, X., Sherman, S., Hess, M.M., Sanger, W.G., Chan, W.C., and Dave, B.J. Clonal Evolution in t(14;18)-Positive Follicular Lymphoma, Evidence for Multiple Common Pathways and Frequent Parallel Clonal Evolution. Clin Cancer Res, November 15, 14(22): 7180-7187, 2008.
  • Lynch, H.T., Sanger, W.G., Weisenburger, D.D., Thome, S. Genetic Counseling for DAPK1 Mutation in a Chronic Lymphocytic Leukemia Family. Cancer Genet Cytogenet Oct 15, 186(2): 95-102, 2008.
  • Smock, K.J., Nelson, M., Tripp, S.R., Sanger, W.G., Abromowitch, M., Cairo, M.S., and Perkins, S.L. Characterization of Childhood Precursor-T Lymphoblastic Lymphoma by Immunophenotyping and Fluorescent in-situ Hybridization: A Report from the Children’s Oncology Group. Pedi Blood Cancer, Oct. 51(4): 489-494, 2008.
  • Bhagavathi, S., Greiner, T.C., Kazmi, S.A., Fu, K., Sanger, W.G. and Chan, W.C. Primary Central Nervous System Extranodal Marginal Zone Lymphoma of Mucosa Associated Lymphoid Tissue with t(14;18) and Review of Literature. J Hematop Sep; 1(2): 131-137, 2008.
  • Goldman, S., Lynch, J., Davenport, V., Perkins, S., Shiramizu, B., Sanger, W.G., Gross, T., Harrison, L., Bancroft, M. and Cairo, M.; Children’s Oncology Group, Arcadia, CA. Preliminary Results of a Phase II Study of Chemoimmunotherapy (Rituximab + FAB Chemotherapy) in Children and Adolescents with Intermediate Risk B-cell NHL: A Children’s Oncology Group Report. (Submitted), 2008.
  • Choi, W.L., Fu, K., Dave, B.J., Sanger, W.G., Smith L.M., Chan, W.C., Hans, C.P., Weisenburger, D.D., and Greiner, T.C. Follicular Lymphoma with BCL6 Rearrangements but without a t(14;18): Deceptive Histological Features that May Lead to Diagnostic Pitfalls. (Submitted), 2008.

Professional Affiliations:

  • American Association of Tissue Banks
  • American College of Medical Genetics
  • American Fertility Society
  • American Genetics Association
  • American Society of Hematology (ASH)
  • American Society of Human Genetics
  • Association of Clinical Scientists
  • Children's Cancer Group
  • Children’s Oncology Group - Lymphoma Cytogenetics
  • Council of Regional Networks for Genetics Services (CORN)
  • Great Plains Genetic Service Network
  • Lymphoma Study Group Prioritization Committee
  • March of Dimes, Southeast Chapter
  • Midwest Clinical Genetics Society
  • Society of Andrology
  • Society of Cryobiology
  • Society of Sigma Xi
  • Tissue Culture Association