Warren G. Sanger, PhD

Warren SangerWarren G. Sanger, PhD
Human Genetics Laboratories
Munroe-Meyer Institute
985440 Nebraska Medical Center
Omaha, NE 68198-5440

Phone: (402) 559-5070
E-mail: wgsanger@unmc.edu

Professional Summary:

Dr. Sanger is the Director of the Human Genetics Laboratories (Cytogenetics and Molecular Cytogenetics Laboratories) and Interim Director of Clinical Genetics at the Munroe-Meyer Institute, University of Nebraska Medical Center in Omaha, Nebraska. He is a Founding Fellow of the American Board of Medical Genetics and is Board Certified as a Clinical Cytogeneticist and Medical Geneticist by the American College of Medical Genetics and American Medical Association.

Dr. Sanger served in the military at the University of Maryland, Far East Division (Seoul, Korea) as a counter intelligence agent and an Instructor in Biology, January 1969 to December 1971. He received his Ph.D. in 1974 and joined the University of Nebraska Medical Center in 1975. Dr. Sanger is a Professor of Pediatrics, Munroe-Meyer Institute and Pathology at the University of Nebraska Medical Center and serves as a Cytogenetics Advisor for several organizations. The Cytogenetics Laboratory provides over 14,000 diagnostic studies and 2,500 research studies per year in the areas of oncology, prenatal health, birth defects, and other molecular genetics projects. Primary research interests are in the areas of cancer genetics, genetic causes of birth defects and developmental disabilities, prenatal diagnosis and prenatal care.

Education:

PhD, University of Nebraska, Lincoln, NE and University of Nebraska Medical Center, Omaha, NE, 1974
MS, University of Nebraska, Lincoln, NE, 1969
BS, Kearney State College, Kearney, NE, 1967
BS, University of Nebraska, Lincoln, NE, 1964

Courses Taught:

Human Genetics 518
Human Cytogenetics Elective
Metabolic Disease and Genetics Elective
Human Genetics 911
Human Cytogenetics 912
Human Cytogenetics Rotations for OB/GYN, Pathology and Pediatrics Residents
Invited Lecturer for graduate courses in Pharmacology, Neurology, Anatomy, Biochemistry, Pathology
and various UNL courses

Research Interests and Projects:

  • Analysis of Post-transplant Lymphoma by cDNA Microarray
  • Childhood B-NHL: Pathological-Immunological-Genetic Study
  • Chronic Myelogenous Leukemia
  • Cytogenetics of Breast and Ovarian Cancer
  • Detection and implications of Occult Tumor Cells in Human Bone Marrow
  • Development of Immune- Therapy for CML
  • Etiological Factors and Mechanisms in Lymphomagenesis
  • Familial Basal Cell Carcinoma Syndromes
  • Gene Expression Analysis by DNA Microarray
  • Genetic Policy
  • Genetics and Birth Defects Service
  • Immunopathology of the X-linked Lymphoproliferative Syndrome
  • Investigation of Chromosome Damage among Farmers and Other Pesticide Applicators
  • Maternal Serum Screening for the Identification of High Risk Pregnancies in Nebraska Education, Coordination and Counseling
  • Molecular Genetics of Genetic Analysis of Fetal Cells From Maternal Circulation
  • Novel Restriction Fragment Polymorphisms and Neoplasia
  • Pancreatic Carcinogenesis
  • Pediatric Hodgkin's Disease
  • Prenatal Screening of Uncultured and Cultured Amniocytes Utilizing Direct Label Probes
  • The Effects of Subfertility on Parent-Child Relation and Child Behavior

Publications: (within the last 5 years)

  • Schaefer, G.B., Starr, L., Pickering, D., Skar, G., DeHaai, K., and Sanger, W.G. Array CGH Findings in a Cohort Referred for an Autism Evaluation. In Press, 2010..
  • Marušiæ, Z., Zovak, M., Hagenkord, J.M., Kash, S., Koul, M.S., Sanger, W.G., Gatalica, A., Krušlin, B., and Tomas, D. Papillary Renal Cell-like Carcinoma in a Retroperitoneal Teratoma. Patholog International, Submitted, 2010.
  • Moreno-de-Luca, D., Kaminsky, E.B., Myers, S.M., Adam, M.P., Pakila, A., Eisenhauer, N.J., Uhas, K., Weik, L., Guy, L., Rossi, M.R., Care, M.E., Morel, C.F., Boni, M., Salbert. B., Pearce, B.D., Chandrareddy, A., Demmer, L.A., Chow, W.C., Surti, U., Hegde, M., Sanger, W.G., Aradhya, S., Martin, C.L., and Ledbetter, D.H. Sex-specific Risk for Autism Associated with Recurrent 17q12 Microdeletion. Nature Genetics. Submitted, 2010.
  • Lim, A.S., Lim, T.H., Tien, S.L., Hess, M.H., Kee, S.K., Lau, Y., Gilbert, R., Hempel, T., Anderson, K., Zaleski, D.H., Chia, P., Raman, S., Tan, H.K., Tan, A, S., Sanger, W.G. Is Rapid Aneuploidy Screening with FISH as a Stand-alone Test Sufficiently Robust in Prenatal Diagnosis? Submitted, 2010.
  • Macferran, K.L., Buchmann, R.F., Ramakrishnaih, R., Griebel, M.L., Sanger, W.G., Saronwala, A., Schaefer, G.B. Pontine Tegmental Cap Dysplasia with a 2q13 Micro-deletion Involving the NPHP1 Gene: Insight into Malformations of the Mid-Hind Brain. Pediatric Neurology, (in press) 2010.
  • Peterson, C., Lester, D.R. and Sanger, W.G. Burkitt’s Lymphoma in Early Pregnancy. Journal of Clinical Oncology Vol 28, 2010.
  • Naushad, H., Choi, W., Page, C.J., Weisenburger, D.D., Sanger, W.G., and Aoun, P. Mantle Cell Lymphoma with Flow Cytometric Evidence of Clonal Plasmacytic Differentiation: A Case Report. Cytometry B Clin Cytom, May; 76(3): 218-224, 2009.
  • Poirel, H.A., Cairo, M.S., Heerema, N., Swansbury, J., Auperin, A., Launay, E., Sanger, W.G., Talley, P., Perkins, S.L., Raphael, M., McCarthy, K., Sposto, R., Gerrard, M., Bernheim, A., and Patte, C. Specific Cytogenetic Abnormalities are Associated with a Significantly Inferior Outcome in Children and Adolescents with Mature B-cell Non-Hodgkin’s Lymphoma: Results of the FAB/LMB 96 International Study. Leukemia 23(2): 323-331, 2009.
  • Gu, K., Fu, K., Jain, S., Liu, Z., Chan, J., Weisenburger, D.D., Greiner, T., Aoun, P., Sanger, W.G., Iqbal, J. , and Dave, B. t(14;18) - Negative Follicular Lymphoma are Associated with a High Frequency of BCL6 Rearrangement at the Alternative Breakpoint Region. Modern Pathol, Sep; 22(9): 1251-1257, 2009.
  • Tsuchiya, K.D., Shaffer, L.G., Aradhya, S., Biggerstaff, J., Gastier-Foster, J., Patel, A., Rudd, M.K., Sanger, W.G., Schwartz, S., Tepperberg J., Thorland, E., Torchia, B., and Brothman, A. Variability in Interpreting & Reporting Copy Number Changes Detected by Array-based Technology in Clinical Laboratories. Genetics in Medicine, 11(12): December 866-873, 2009.
  • Dave, J., Olney, A.H., Zaleski, D., Pickering, D., Becker, T.A., Chipman, H.E., and Sanger, W.G. Inherited 14q Duplication and 21q Deletion: A Rare Adjacent-2 Segregation in Multiple Family Members. Am J Med Genet Part A 149A: 2248-2253, 2009.
  • Nelson, M., Perkins, S., Dave, B., Coccia, P., Bridge, J., Lyden, E., Heerema, N., Lones, M., Harrison, L., Cairo, M., and Sanger, W.G. An Increased Frequency of 13q Deletions Detected by Fluorescence In Situ Hybridization and Its Impact on Survival in Children and Adolescents with Burkitt Lymphoma: Results from the Children’s Oncology Group CCG-5961. British Journal of Haematology 1-11. Doi:10.1111/j.1365-2141, 2009.
  • Dave, B.J., Olney, A.H., Zaleski, D.H., Pickering, D.L., Becker, T.A., Chipman, H.E., and Sanger, W.G. Inherited 14q Duplication and 21q Deletion: A Rare Adjacent-2 Segregation in Multiple Family Members. Am J Med Genet A. Oct 149(10): 2248-2253, 2009.
  • Lones, M.A., Raphael, M., McCarthy, K., Wotherspoon, A., Terrier-Lacombe, M., Ramsay, A.D., MacLennan, K., Cairo, M.S., Gerrard, M., Michon, J., Patte, C., Pinkerton, R., Sender, L., Auperin A., Sposto, R., Weston, C., Heerema, N.A., Sanger, W.G., Bernheim, A., Poirel, H., Swansbury, J., Talley, P., and Perkins, S.L. Primary Follicular Large Cell Lymphoma of the Testis in Children and Adolescents: A Report for CCG-5961. British J. Of Hematology, (In press), 2009.

Professional Affiliations:

  • American Association of Tissue Banks
  • American College of Medical Genetics
  • American Fertility Society
  • American Genetics Association
  • American Society of Hematology (ASH)
  • American Society of Human Genetics
  • Association of Clinical Scientists
  • Children's Cancer Group
  • Children’s Oncology Group - Lymphoma Cytogenetics
  • Council of Regional Networks for Genetics Services (CORN)
  • Great Plains Genetic Service Network
  • Lymphoma Study Group Prioritization Committee
  • March of Dimes, Southeast Chapter
  • Midwest Clinical Genetics Society
  • Society of Andrology
  • Society of Cryobiology
  • Society of Sigma Xi
  • Tissue Culture Association