The LTQ Orbitrap XL ETD (ThemoFisher, Inc) is the only ETD instrument with both high resolution and accurate mass, enabling definitive protein characterization. This technology enables highly sensitive post-translational modification analyses. It offers three complementary fragmentation techniques in one instrument: CID, HCD and ETD for definitive protein/peptide characterization, post-translational modification (PTM) analysis (especially phosphorylation); and top-down or middle-down sequencing of proteins and peptides.