Departmental Research

Below is a list of active clinical research being conducted in the Department of Neurological Sciences. Please use the Clinical Trials link provided for specific details on these clinical trials as well as other clinical research being conducted at UNMC.

 

Title/Description

PI

Recruitment Status

 

Alzheimer's Disease

Effect of Passive Immunization on the Progression of Mild Alzheimer's Disease: Solanezumab (LY2062430) Versus Placebo

Murman

 

Recruiting

Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4 Study)

Murman

 Recruiting

A Phase 2 multi-center, randomized, double blind, placebo controlled, parallel group study to evaluate the efficacy and safety of T-817MA in patients with mild to moderate Alzheimer's Disease

Murman

 

 

Recruiting

 

 

ALS

Multicenter ALS Cohort Study of Oxidative Stress and Disease Progression

Fernandes

 

Phase 2 Study of Rasagiline for Treatment of Amyotrophic Lateral Sclerosis

Fernandes

Recruiting

HDE Post-Approval Study (PAS) of NeuRx DPSP™ for ALS

Fernandes

 Recruiting

(ALS) NeuRx DPS, Diaphragm Pacing System

Fernandes

 

 

 

Behavioral/Geriatric

Creatine Safety, Tolerability, & Efficacy in Huntington's Disease (CREST-E)

Torres

Recruitment Closed

 

 

Movement Disorders

*Open-Label Continuation Treatment Study With Levodopa-Carbidopa Intestinal Gel in Subjects With Advanced Parkinson's Disease and Severe Motor-Fluctuations Who Have Exhibited A Persistent and Positive Effect to Treatment In Previous Studies* Site #112

Bertoni

 Recruitment Closed

 

 

Multiple Sclerosis

Long-term, prospective, multinational, parallel-cohort study monitoring safety in patients with MS newly started with fingolimod once daily or treated with another approved disease-modifying therapy

Zabad

 

Recruiting

A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of the Efficacy of Natalizumab on Reducing Disability Progression in Subjects With Secondary Progressive Multiple Sclerosis

Zabad

 

Recruitment Closed

JCVAantibody Program in Patients with Relapsing Multiple Sclerosis Receiving or Considering Treatment with Tysabri

Zabad

Recruitment Closed

A Randomized, Double-Blind, Double-Dummy, Parallel-Group Study to Evaluate the Efficacy and Safety of Ocrelizumab in Comparison to Interferon Beta-1a (Rebif) in Patients With Relapsing Multiple Sclerosis (“OPERA” Study Program)

Zabad

 

Recruitment Closed

A Multicenter, Open-Label, 12-Month Observational Study Evaluating the Clinical Effectiveness and Impact on Patient-Reported Outcomes of Oral Tecfidera™ Delayed-Release Capsules in Patients With Relapsing Forms of Multiple Sclerosis After Suboptimal Response to Glatiramer Acetate

Zabad

 

 

Recruiting

A Clinical Evaluation Of The Safety Of Baclofen ER Capsules (GRS) When Administered Once Daily To Subjects With Spasticity Due To Multiple Sclerosis (MS): An Open Label, Long Term, Safety Trial

Zabad

 

Recruitment Pending

A Placebo-Controlled Randomized Withdrawal Evaluation of the Efficacy and Safety of Baclofen ER Capsules (GRS) in Subjects with Spasticity Due to Multiple Sclerosis

Zabad

 

Recruiting

 

 

Parkinson's Disease

A clinical study of Patients with symptomatic neurogenic orthostatic Hypotension to assess sustained effects of droXidopa therapy

Thai

 

Phase 3 Double-blind Placebo-controlled Parallel Group Study of Isradipine as a Disease Modifying Agent in Subjects With Early Parkinson Disease

 Bertoni

 Recruitment Pending

 

 

Stroke

A Randomized, Placebo Controlled Trial of Pioglitazone, Compared with Placebo for Prevention of Recurrent Stroke and Myocardial Infarction after Ischemic Stroke

Fayad

 

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