The mammalian ovary provides not only eggs for reproduction, but also female hormones, which are important for women’s health. However, many pathological processes take place in the ovary causing infertility, subfertility and diseases such as premature ovarian failure, polycystic ovary syndrome and ovarian cancer. Our long-term goal is to identify the intra-ovary signals and molecules that contribute to the physiological and pathological changes in the ovary so that novel diagnostic or therapeutic methods can be developed to improve women’s health.
Infertility is a major health problem and affects about 12 percent of women of the reproductive age in the US. More than 20,000 cases of ovarian cancer have been detected and approximately 15,000 women will die from ovarian cancer each year in the US. Research that facilitates a better understanding of the mechanisms underlying the regulation of ovarian cellular events are critically important for improving women’s health. Our research focuses on the molecular and cellular regulation of the ovary under both physiological and pathological conditions. We are especially interested in the function of hormones and growth factors that regulate the growth of ovarian follicles, granulosa cell tumor development, and the initiation and progression of ovarian epithelial cancers.
Cheng Wang, PhD
- Molecular Reproductive Endocrinology Laboratory
- Signal Transduction Laboratory
- Laboratory of Ovarian Cancer