Oxidative stress and free radical biology, Microbial infections, Tumor immunology, and Cancer biology.
I have been investigating the role of free radicals and reactive oxygen species (ROS) in cancer and the infection process since my Ph.D. work at the University of Iowa, and have continued this work as faculty member. I have also worked on molecular immunology and cancer biology at the NIH. I am currently conducting research in the fields of ROS, immune cells, and virulence factors associated with bacterial infection. In addition, I am studying the role of iron intake and metabolism in the pathogenicity associated with Mycobacterium tuberculosis that grow and replicate in human macrophages, with emphasis on identifying strategies to boost the efficacy of disease treatment.
Education and Training
B.Sc., Medical Laboratory Technology, Kuwait University, Kuwait City, Kuwait, 1989
M.Sc., Medical Laboratory Technology/Immunology, Jordan University of Science and Technology, Irbid, Jordan, 1999
Ph.D., Free Radicals and Cancer Biology, University of Iowa, College of Medicine, Iowa City, Iowa, USA, 2003
Postdoctoral training, University of Iowa,College of Medicine, Iowa City, Iowa, USA, 2004
Visiting Scientist, Center for Cancer Research (CCR), National Cancer Institute (NCI)/ National Institute of Health (NIH), Bethesda, MD, 2009- 2011
Society for Free Radical Biology and Medicine
American Association for Cancer Research
Olakanmi O, Kesavalu B, Abdalla MY, Britigan BE. Iron acquisition by Mycobacterium tuberculosis residing within myeloid dendritic cells. Microb Pathog. 65, 21–28. 2013.
Olakanmi O, Kesavalu B, Pasula R,Abdalla MY, Schlesinger LS, Britigan BE. Gallium Nitrate is Efficacious in Murine Models of Tuberculosis and Inhibits Key Bacterial Fe-Dependent Enzymes. Antimicrob Agents Chemother. 57 (12), 6074-6080. 2013
Abdalla MY, Mathahs MM, Ahmad IM. Reduced heme oxygenase-1 expression in steatotic livers infected with hepatitis C virus. European Journal of Internal Medicine. 2012, Oct;23(7):649-55.
Mkrtichyan M, Najjar YG, Raulfs EC, Abdalla MY, Samara R, Rotem-Yehudar R,Cook L, Khleif SN. Anti-PD-1 synergizes with cyclophosphamide to induce potent anti-tumor vaccine effects through novel mechanisms. Eur J Immunol. 2011Oct;41(10):2977-86. PubMed PMID:21710477.
Abdalla MY, Fawzi M, Al-Maloul SR, El-Banna N, Tayyem RF, Ahmad IM. Increased oxidative stress and iron overload in Jordanian β-thalassemic children. Hemoglobin. 2011;35(1):67-79. PubMed PMID: 21250883.
Ahmad IM, Britigan BE, Abdalla MY. Oxidation of thiols and modification of redox-sensitive signaling in human lung epithelial cells exposed to Pseudomona spyocyanin. J Toxicol Environ Health A. 2011;74(1):43-51. PubMed PMID: 21120747.
Abu-Surrah AS, Abu Safieh KA, Ahmad IM, Abdalla MY, Ayoub MT, Qaroush AK,Abu-Mahtheieh AM. New palladium(II) complexes bearing pyrazole-based Schiff base ligands: synthesis, characterization and cytotoxicity. Eur J Med Chem. 2010 Feb;45(2):471-5. PubMed PMID: 19913953.
Tahtamouni LH, Mustafa NH, Alfaouri AA, Hassan IM, Abdalla MY, Yasin SR. Prevalence and risk factors for anabolic-androgenic steroid abuse among Jordanian collegiate students and athletes. Eur J Public Health. 2008 Dec;18(6):661-5. PubMed PMID: 18603598.
Ahmad IM, Abdalla MY, Aykin-Burns N, Simons AL, Oberley LW, Domann FE, Spitz DR. 2-Deoxyglucose combined with wild-type p53 over expression enhanced cytotoxicity in human prostate cancer cells via oxidative stress. Free Radic BiolMed. 2008 Mar 1;44(5):826-34. PubMed PMID: 18155176; PubMed Central PMCID: PMC2350201.
Abdalla MY, Ahmad IM, Spitz DR, Schmidt WN, Britigan BE. Hepatitis C virus-core and non structural proteins lead to different effects on cellular antioxidant defenses. J Med Virol. 2005 Aug;76(4):489-97. PubMed PMID: 15977232.
Abdalla MY, Britigan BE, Wen F, Icardi M, McCormick ML, LaBrecque DR, Voigt M,Brown KE, Schmidt WN. Down-regulation of heme oxygenase-1 by hepatitis C virus infection in vivo and by the in vitro expression of hepatitis C core protein. JInfect Dis. 2004 Sep 15;190(6):1109-18. PubMed PMID: 15319861.
Wen F, Abdalla MY, Aloman C, Xiang J, Ahmad IM, Walewski J, McCormick ML,Brown KE, Branch AD, Spitz DR, Britigan BE, Schmidt WN. Increased prooxidant production and enhanced susceptibility to glutathione depletion in HepG2 cells co-expressing HCV core protein and CYP2E1. J Med Virol. 2004 Feb;72(2):230-40.PubMed PMID: 14695664.
O'Malley YQ, Abdalla MY, McCormick ML, Reszka KJ, Denning GM, Britigan BE. Subcellular localization of Pseudomonas pyocyanin cytotoxicity in human lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2003 Feb;284(2):L420-30. PMID: 12414438