About Mammalian Cell Adhesion Molecule (MCAM) database

MCAM database is developed by Laboratory of Tumor Microenvironment at University of Nebraska Medical Center, Omaha, NE as part of a project to identify metastatic markers, which are adhesion molecules that help the cancer cells to home to a specific organ of metastasis. This is the first database known to be developed for cell adhesion molecules. MCAM is an interactive web-based database serving the biology community to search sequence and details of CAMs including gene expression available from the mammalian genome. MCAM database is a database of cell adhesion molecules from mouse, human and rat. MCAM contains information about adhesion molecules from mouse, human and rat collected mainly from Gene Ontology (GO) and Gene (NCBI) database and cross referenced with SwissProt database. The information about the adhesion molecules collected from the database was used to curate data and information from various primary and secondary database sources. Primarily the database was created exclusively for mouse adhesion molecules and the data from the mouse were used as a reference to curate the orthologs available from the human and rat. This collected information were unified as a relational database using Microsoft Access and made available online.

MCAM database, Version 3.0

  • The version 3.0 has been updated from Local Mouse Cell Adhesion Molecule (LMCAM, version 2.0) Database and Mouse Cell Adhesion Molecule (MCAM, version 2.0).
  • LMCAM is available in compact disc (CD).
  • MCAM in http://molbio.unmc.edu/MCAM/MCAM.html.
  • Both LMCAM and MCAM are flat-file databases whereas MCAM is searchable database available online for users. MCAM has been updated with web links from different database sources as mentioned earlier.

Construction of MCAM, Version 3.0 database
A graphic representative of the how the MCAM database is constructed.

Statistics of MCAM, version 3.0 database
The functional terms from GO database and number of entries in the database from different source databases corresponding to the GO entries are shown.

Functional Terms GO GenBank (FASTA) UNIGENE PIR
Calcium dependent cell adhesion 12 6 8 25
Calcium independent cell adhesion 13 6 4 18
Cell adhesion 175 92 87 219
Cell-cell adhesion 50 23 19 52
Heterophilic cell adhesion 8 5 5 12
Homophilic cell adhesion 54 39 39 2
Positive regulation cell adhesion 2 1 1 2
Regulation cell adhesion 20 8 8 25

The number of entries from different sources for mouse, human and rat has been listed.

Sources Mouse Human Rat
GenBank 502 311 49
GenPept 430 147 135
PIR 472 154 67
UniProt 418 149 72
UniGene 610 184 80

The number of entries of cell adhesion molecules according to Superfamily Classification.

Superfamily Classification Number of Entries
Cadherin 47
Immunoglobulin 107
Integrin 21
Selectin 4
Unknown 78

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