Robert J. Boissy Ph.D.

Department Affiliations 
Assistant Professor 

Interests 
Responsible Bioinformatics

I work mainly, but not exclusively, on research projects that involve the management and analysis of what is commonly referred to as "next-generation DNA sequencing data" or simply "NGS data". 

One general research area that I find especially interesting is high-performance computational hardware and software systems for extremely time-sensitive NGS data analyses, e.g.: (a) screening of newborns for currently un-diagnosable inherited disorders (especially those where, if timely, beneficial intervention may be possible); (b) detecting the compromise of transplant organs and subsequently their recipients by otherwise undetectable infectious agents present in the former; and (c) early detection and monitoring of infectious disease outbreaks.

To learn more about what Dr. Boissy's expertise can provide for researchers please see his Bioinformatics page.

Education and Training 
Ph.D., Biochemistry & Molecular Biology, The University of British Columbia

Notable Publications 
Lada AG, Stepchenkova EG, Waisertreiger ISR, Noskov VN, Dhar A, Eudy JD, Boissy RJ, Hirano M, Rogozin IB, & Pavlov Y (2013).  Genome-wide mutation avalanches induced in diploid yeast cells by a base analog or an APOBEC deaminase.  PLoS Genetics Sep; 9(9):e1003736. doi: 10.1371/journal.pgen.1003736. PMID: 24039593; PMCID: PMC3764175.

Fey PD, Endres JL, Yajjala VK, Widhelm TJ, Boissy RJ, Bose JL, Bayles KW. (2013) A Genetic Resource for Rapid and Comprehensive Phenotype Screening of Nonessential Staphylococcus aureus Genes. MBio 4(1); pii: e00537-12. doi: 10.1128/mBio.00537-12. PMID: 23404398; PMCID: PMC3573662.

Lada AG, Dhar A, Boissy RJ, Hirano M, Rubel AA, Rogozin IB, Pavlov YI. (2012) AID/APOBEC cytosine deaminase induces genome-wide kataegis. Biol. Direct 7:47 doi:10.1186/1745-6150-7-47 PMID: 23249472; PMCID: PMC3542020.

Ahmed A, Earl J, Retchless A, Hillier SL, Rabe LK, Cherpes TL, Powell E, Janto B, Eutsey R, Hiller NL, Boissy R, Dahlgren ME, Hall BG, Costerton JW, Post JC, Hu FZ, Ehrlich GD (2012) Comparative Genomic Analyses of 17 Clinical Isolates of Gardnerella vaginalis Provide Evidence of Multiple Genetically Isolated Clades Consistent with Subspeciation into Genovars. J Bacteriol. 194(15):3922-37. doi: 10.1128/JB.00056-12 PMID: 22609915; PMCID: PMC3416530.

Boissy R, Ahmed A, Janto B, Earl J, Hall BG, Hogg J, Pusch GD, Hiller NL, Powell E, Hayes J, Yu S, Kathju S, Stoodley P, Post JC, Hu FZ & Ehrlich GD. (2011). Comparative supragenomic analyses among the pathogens Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae using a modification of the finite supragenome model. BMC Genomics 2011, 12:187doi:10.1186/1471-2164-12-187. PMID:21489287; PMCID: PMC3094309.

Hiller NL, Ahmed A, Powell E, Martin DP, Eutsey R, Earl J, Janto B, Boissy RJ, Hogg J, Barbadora K, Sampath R, Lonergan S, Post JC, Hu FZ & Ehrlich GD. (2010). Generation of genic diversity among Streptococcus pneumoniae strains via horizontal gene transfer during a chronic polyclonal pediatric infection. PLoS Pathog 6(9): e1001108. PMID: 20862314; PMCID: PMC2940740.

Hiller NL, Janto B, Hogg JS, Boissy R, Yu S, Powell E, Keefe R, Ehrlich NE, Shen K, Hayes J, Barbadora K, Klimke W, Dernovoy D, Tatusova T, Parkhill J, Bentley SD, Post JC, Ehrlich GD & Hu FZ. (2007). Comparative genomic analyses of seventeen Streptococcus pneumoniae strains: Insights into the pneumococcal supragenome. J Bacteriol, 189, 8186-8195. PMID: 17675389; PMCID: PMC2168654.

Mußmann M, Hu FZ, Richter M, deBeer D, Preisler A, Jørgensen BB, Huntemann M, Glöckner FO, Amann R, Koopman WJH, Lasken RS, Janto B, Hogg J, Stoodley P, Boissy R & Ehrlich GD. (2007). Insights into the genome of large sulphur bacteria revealed by analysis of single filaments. PLoS Biology Vol. 5, No.9, e230 doi:10.1371/journal.pbio.0050230. PMID: 17760503; PMCID: PMC1951784.

Hogg JS, Hu FZ, Janto B, Boissy R, Hayes J, Keefe R, Post JC & Ehrlich GD. (2007). Characterization and modeling of the Haemophilus influenzae core- and supra-genomes based on the complete genomic sequences of Rd and 12 clinical nontypeable strains. Genome Biol. 2007, 8:R103 doi:10.1186/gb-2007-8-6-r103. PMID: 17550610; PMCID: PMC2394751.

Carreon T, Ruder AM, Schulte PA, Hayes RB, Rothman N, Waters M, Grant DJ, Boissy R, Bell DA, Kadlubar FF, Hemstreet GP 3rd, Yin S & LeMasters GK. (2006). NAT2 slow acetylation and bladder cancer in workers exposed to benzidine. Int J Cancer 118, 161-8. PMID: 16003747.

Boissy R, Watson MA, Umbach D, Deakin M, Elder J, Strange RC & Bell DA. (2000). A pilot study investigating the role of NAT1 and NAT2 polymorphisms in gastric adenocarcinoma. Intl. J. Cancer 87, 507-511. PMID: 10918189.

Millikan RC, Pittman GS, Tse CK, Duell E, Newman B, Savitz D, Moorman PG, Boissy RJ & Bell DA. (1998) Catechol O-methyl transferase and breast cancer risk. Carcinogenesis 19, 1943-1947. PMID: 9855007.

 

Robert J. Boissy, Ph.D.
Robert Boissy
Email
rboissy@unmc.edu 

Mailing Address 
985900 Nebraska Medical Center 
Omaha, NE 68198-5900

Office Address 
DRC2 7034

Phone Number 
Office: 402-559-4307

Fax Number 
402-559-5900

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