Director, Tissue Banking Core Facility
Associate Director, Clinical Cytogenetics
Director, Sarcoma Rearrangement Testing for Molecular Diagnostics
Director, The Nebraska Medical Center/Methodist Collaborative Fluorescence In Situ Hybridization (FISH) Laboratory
Cytopathology, Pathology of Bone and Soft Tissue Tumors
My research involves several aspects of genetics with special emphasis on cancer genetics of bone and soft tissue tumors. Over the last few years, a number of tumor specific chromosomal abnormalities have been identified for both benign and malignant bone and soft tissue tumors. These abnormalities are important diagnostically and prognostically, as well as defining treatment strategies. These data have also contributed significantly to our understanding of the histopathogenesis of many of these neoplasms. Following identification of the anomalies cytogenetically, the key chromosomal breakpoint locations are further characterized with molecular techniques. Moreover, molecular cytogenetic analysis utilizing probes from these defined breakpoints can be developed as an additional diagnostic adjunct. Recently, we have defined the underlying molecular events in several sarcoma and lymphoma subtypes.
Education and Training
B.S., University of Nebraska, Lincoln, NE, 1984
M.D., University of Nebraska Medical Center, Omaha, NE, 1984
Pathology Residency, University of Kansas Medical Center, Kansas City, KS, 1984-1988
Special Fellow in Cytogenetics, University of Nebraska Medical Center, University of Kansas Medical Center, 1988-1989
Molecular Biology Fellow, Southwest Biomedical Research Institute, Scottsdale, AZ, 1989-1990
Introduction to Molecular Pathology, United States and Canadian Academy of Pathology
Pharmacy Medical Students - Introduction to Processes Course 630 Lectures on Genetic Disorders, Cytogenetics
Genetic Disorders, Cytogenetics
Graduate Students - Cytogenetics 912, Molecular Cytogenetics; Molecular Basis for Human Diseases
Faculty Advisor for two MS Student, one post-doctoral student
Residents - Cytogenetics Case Conference; Cytopathology & Cytogenetics Rotation
Cytology Technologist Students - urine, bone & soft tissue tumors Departmental Graduate Committee
Editorial Board, Cancer Genetics and Cytogenetics
Editorial Board, The Journal of Molecular Diagnostics
Editorial Board, Modern Pathology
Council and Pathology Resident Ambassador, United States and Canadian Academy of Pathology
Pathobiology Committee and Cytogenetics Reference Laboratory for Sarcomas, Children�s Oncology Group
American Society of Human Genetics
Orthopaedic Research Society
Alpha Omega Alpha Honor Medical Society
Nebraska Pathology Society
American Society of Clinical Oncology
American College of Medical Genetics
American Society of Pediatric Pathology
United States and Canadian Academy of Pathology
Connective Tissue Oncology Society
Association for Molecular Pathology
International Skeletal Society
Founding Member, International Society of Bone and Soft Tissue Pathology
College of American Pathologists
Bridge JA, Nelson M. Genetics of Soft Tissue Pathology. In: M. Miettinen (ed), Modern Soft Tissue Pathology, Cambridge University Press, pp 105-126, 2010.
Huang D, Sumegi J, Dal Cin P, Reith JD, Yasuda T, Nelson M, Muirhead D, Bridge JA. C11orf95-MKL2 is the Resulting Fusion Oncogene of t(11;16)(q13;p13) in Chondroid Lipoma. Genes Chrom and Cancer, 49(9):810-8, 2010.
Bridge JA, Bowen JM, Smith RB. The Small Round Blue Cell Tumors of the Sinonasal Area. Head and Neck Pathol, 4:84-93, 2010
Sumegi J, Streblow R, Frayer RW, Dal Cin P, Rosenberg A, Meloni-Ehrig A, Bridge JA. Recurrent t(2;2) and t(2;8) Translocations in Rhabdomyosarcoma without the Canonical PAX-FOXO1 fuse PAX3 to Members of the Nuclear Receptor Transcriptional Coactivator Family. Genes Chrom Cancer, 49(3):224-36, 2010.
Nezelof C, Seemayer TA, Bridge JA. Contributions of pediatrics and pediatric pathology to the body of knowledge regarding human disease. Hum Pathol, 41(3):309-15, 2010.
Alaggio R, Coffin CM, Weiss SW, Bridge JA, Issakov J, Oliveira AM, Folpe AL. Liposarcomas in Children and Young Adults: A Study of 82 cases. Am J Surg Pathol, 33(5):645-58, 2009.
Kim HJ, Shen S, Ayala A, Ro JY, Truong L, Alvarez K, Bridge JA, Gatalica Z, Gonzalez-Berjon J, and Monzon FA. Virtual-karyotyping with SNP Microarrays in Morphologically Challenging Renal Cell Neoplasms: A Practical and Useful Diagnostic Modality. Am J Surg Pathol, (33)(9):1276-86, 2009.
Yasuda T, Perry KD, Nelson M, Bui MM, Nasir A, Goldschmidt, Gnepp DR, Bridge JA. Alveolar Rhabdomyosarcoma of the Head and Neck Region in Older Adults; Genetic Characterization and a Review of the Literature. Hum Pathol, 40(3):341-8, 2009.
Bridge JA. Contribution of Cytogenetics to the Management of Poorly Differentiated Sarcomas. Ultrastruct Pathol, 32(2):63-71, 2008.
Stevens R, Almanaseer I, Gonzalez M, Caglar D, Knudson RA, Ketterling RP, Schrock D, Seemayer TA, Bridge JA. Analysis of HER-2 gene amplification using an automated FISH signal enumeration system. J Mol Diagn, 9:144-150, 2007.
For a detailed list of publications, click here.
983135 Nebraska Medical Center
Omaha, NE, 68198-3135