Wing-Chung (John) Chan, M.D.

Department Affiliations
Amelia and Austin Vickery Professor of Pathology

Hematopathology, Lymphoma Biology and Pathogenesis, Development and Refinement of Molecular Assays
For information on the research that Dr. Chan is conducting in the field of lymphoma, please see his research webpage.

Education and Training
MBBS, M.D.; University of Hong Kong
Residency, University of Chicago, 1975-1979
Immunology Research, University of Chicago, 1979- 1980
Board Certification: AP, CP, HP

Teaching Activities
Teaching responsibilities include lectures and small group discussions in pathology and microbiology for medical students. Teaching and supervising residents and fellows in Hematopathology, graduate students and post-doctoral fellows, mentoring of junior faculty members.
Invited speaker to various national and international meetings

National Activities
Editorial Board and past associate editor, American Journal of Pathology
Editorial Board, American Journal of Clinical Pathology
Lymphoma/Leukemia Molecular Profiling Project: Co-chair of Coordinating Committee and Chair of Pathology Committee
Scientific Advisory Board, Lymphoma Research Foundation
Ad Hoc member: various NIH study sections
Fellow, AAAS

Notable Publications
Rimsza LM, Chan WC, Gascoyne RD, et al. CIITA or RFX coding region loss of function mutations occur rarely in diffuse large B-cell lymphoma cases and cell lines with low levels of major histocompatibility complex class II expression. Haematologica, 2009, 94(4), 596-8.

Lenz G, Wright G, Emre T, Kohlhammer H, Dave SS, Davis RD, Carty S, Lam LT, Shaffer AL, Xiao W, Powell J, Rosenwald A, Ott G, Muller-Hermelink HK, Gascoyne RD, Connors JM, Campo E, Jaffe ES, Delabie J, Smeland EB, Rimsza LM, Fisher RI, Weisenburger DD, Chan WC, Staudt LM. Gene Expression Subtypes of Diffuse Large B cell lymphoma Arise by Distinct Genetic Pathways. Proc Natl Acad Sci USA 2008; 105(36): 13520-5.

Lenz G, Wright G, Dave SS, Xiao W, Powell J, Zhao H, Xu W, Tan B, Iqbal J, Vose J, Bast M, Fu K, Weisenburger DD, Greiner TC, Armitage JO, May L, Gascoyne R, Connors M, Troen G, Holte H, Kvaloy S, Dierickx D, Verhoef G, Delabie J, Smeland EB, Jares P, Martinez A, Lopez-Guillermo A,Montserrat E, Campo E, Braziel RM, Miller, T,Rimsza LM, Cook J, Pohlman B, Sweetenham J, Tubbs R, Fisher RI, Hartmann E, Rosenwald A, Ott G, Muller-Hermelink HK, Wrench D, Lister TA, Jaffe ES, Wilson WH, Chan WC, Staudt LM: A Gene Expression-based Survival Predictor For Diffuse Large B Cell Lymphoma Treated With Chemotherapy Plus Rituximab. NEJM 2008; 359(22) 2313-23.

Lenz G, Davis RE, Ngo VN, Lam L, George TC, Wright GW, Dave SS, Zhao H, Xu W, Rosenwald A, Muller-Hermelink HK, Gascoyne RD, Connors J, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Chan WC, Staudt LM, for the Leukemia Lymphoma Molecular Profiling Project. Oncogenic CARD11 Mutations in Diffuse Large B-cell Lymphoma. Science 2008; 319: 1676-1679.

Young KH, Weisenburger DD, Dave B, Smith L, Sanger W, Iqbal J, Campo E, Delabie J, Gascoyne RD, Ott G, Rimsza L, Mueller-Hermelink HK, Jaffe ES, Rosenwald A, Staudt LM, Chan WC, Greiner TC. Mutations in the DNA-Binding Codons of TP53, which are Associated with Decreased Expression of TRAIL Receptor-2, Predict for Poor Survival in Diffuse Large B-cell Lymphoma. Blood 2007; 110: 4396-4405.

Iqbal J, Greiner TC, Patel K, Dave BJ, Smith L, Ji J, Wright G, Sanger WG, Pickering DL, Jain S, Horsman DE, Shen Y, Fu K, Weisenburger DD, Hans CP, Campo E, Gascoyne RD, Rosenwald A, Jaffe ES, Delabie J, Rimsza L, Ott G, Müller-Hermelink K, Connors JM, Vose JM, McKeithan T, Staudt LM, Chan WC. Distinctive Patterns in BCL6 Molecular Alterations and their Functional Consequences in Different Subgroups of Diffuse Large B-cell Lymphoma. Leukemia 2007; 21: 2332-2343.

Pan Z, Shen Y, Ge B, Du C, McKeithan T, Chan WC. Studies of a Germinal Centre B-cell Expressed Gene, GCET2, Suggest its Role as a Membrane Associated Adapter Protein. BJH 2007; 137: 578-590.

Dave SS, Fu K, Wright GW, Lam LT, Kluin P, Boerma E, Greiner TC, Weisenburger DD, Rosenwald A, Ott G, Muller-Hermelink H, Gascoyne RD, Delabie J, Rimsza LM, Braziel RM, Grogan TM, Campo E, Jaffe ES, Dave BJ, Sanger W, Bast M, Vose JM, Armitage JO, Connors JM, Smeland EB, Kvaloy S, Holte H, Fisher RI, Miller TP, Montserrat E, Wilson WH, Bahl M, Zhao H, Yang L, Powell J, Simon R. Chan WC, Staudt LM. Molecular Diagnosis of Burkitt's Lymphoma. NEJM 354: 2431-2442, 2006.

Tam W, Gomez M, Chadburn A, Lee JW, Chan WC, Knowles DM. Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas. Blood 107: 4090-4100, 2006.

Iqbal J, Neppalli VT, Wright G, Dave BJ, Horsman DE, Rosenwald A, Lynch J, Hans CP, Weisenburger DD, Greiner TC, Gascoyne RD, Campo E, Ott G, Müller-Hermelink K, Delabie J, Jaffe ES, Grogan TM, Connors JM, Voxe JM, Armitage JO, Staudt LM, Chan WC. BCL2 expression is a prognostic marker for activated B-cell-like type of diffuse large B-cell lymphoma. JCO 24: 961-968, 2006.

For a detailed list of publications, click here.

Wing-Chung (John) Chan, M.D.
Wing-Chung (John) Chan, MD
Email Address

Mailing Address
983135 Nebraska Medical Center
Omaha, NE 68198-3135

Office Address
MSB 3528

Laboratory Address

Phone Numbers
Office: 402-559-7684
Lab: 402-559-7753