Dr. Bruno Dupuy is an Associate Professor and Laboratory Head of the Bacterial Anaerobes Section at the Institut Pasteur in Paris, France.  He is internationally recognized for his work focused on the pathogenesis of Clostridium difficile, and he has been a pioneer in developing genetic approaches and molecular tools to promote research on this important but challenging pathogen.  Dr. Dupuy’s presentation will focus on metabolic processes that contribute to the synthesis and secretion of the major C difficile toxins TcdA and TcdB as well as the characteristics of epidemic strains.
   Dr. Andrew Camilli is a Professor and Howard Hughes Medical Institute Investigator in the Department of Molecular Biology and Microbiology at Tufts University in Boston, MA.  He is well recognized for his work on two bacterial pathogens, Vibrio cholerae andStreptococcus pneumoniae with more than 87 papers published in the field.  For the ICGPP meeting, Dr. Camilli will present on his recent work using novel mutagenesis approaches combined with next generation sequencing to identify metabolic processes and regulation of virulence in S. pneumoniae.
   Dr. Darren Higgins is a Professor in the Department of Microbiology and Immunobiology at Harvard Medical School.  He is a leading figure in the study of Listeria monocytogenes pathogenesis and in defining human and animal responses to infection.  Dr. Higgins has pioneered novel approaches for pathogen antigen discovery, and he will present his latest work on defining molecular mechanisms of L. monocytogenes pathogenesis as well as the use of attenuated strains of L. monocytogenes for vaccine development.  
   Dr. Jean Lee is an Associate Professor of Medicine at Harvard Medical School and an Associate Microbiologist at Brigham and Women's Hospital.  Dr. Lee is renowned for her studies on S. aureus pathogenesis mechanisms and vaccine development, and she has performed pioneering research on the Staphylococcus aureus capsular polysaccharides and investigated their role in animal models of colonization and infection.  Dr. Lee is a recognized leader in ongoing efforts to develop successful immunotherapeutic approaches for treating S. aureus infection, and for the ICGPP meeting, she will present on her recent work to develop bioconjugate vaccines for S. aureus.  
   Dr. Kelly Doran is an Associate Professor in the Department of Biology at San Diego State University. Dr. Doran is internationally recognized for her work deciphering molecular mechanisms underlying the pathogenesis of Group B Streptococci (GBS).  She has developed a mouse vaginal colonization model that has revealed new insights into Streptococcus agalactiae colonization and disease progression, and she has collaborated with several labs to exploit this model to investigate polymicrobial interactions and colonization mechanisms.