Shi-Jian Ding, Ph.D.

Department Affiliations
Assistant Professor

Interests
Biological Mass Spectrometry, Quantitative Proteomics, Phosphoproteomics and Protein S-nitroyslation Analysis, Cancer Biomarker Discovery and Targeted Therapy
Please see Dr. Ding's lab for more details on his proteomics research.

Education and Training
B.S., Lanzhou University, 1999
Ph.D., Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, 2004
Postdoctoral Fellow, Pacific Northwest National Laboratory, 2007

Teaching Activities
Summer Students and Graduate Students

National Activities
Best Poster Award, HUPO, 2006
Member, Human Proteome Organization
Member, American Society for Mass Spectrometry

Notable Publications
Huang X, Tolmachev AV, Shen Y, Liu M, Huang L, Zhang ZX, Anderson GA, Smith RD, Chan WC, Hinrichs SH, Fu K, Ding SJ. UNiquant, a Program for Quantitative Proteomics Analysis Using Stable Isotope Labeling. J Proteome Res. 2010 Dec 15. [Epub ahead of print]

Liu M, Hou J, Huang L, Huang X, Heibeck T, Zhao R, Pasa-Tolic L, Smith RD, Li Y, Fu K, Zhang X, Hinrichs SH, Ding SJ. Site-specific proteomic approach for study protein S-nitrosylation. Analytical Chemistry. 2010, 82(17):7160-8.

Heibeck TH; Ding SJ*; Opresko L; Zhao R; Schepmoes A; Camp DG; Smith RD; Wiley S; Qian WJ. Quantitative Analysis of Receptor Tyrosine Signaling in Stimulated Human Mammary Epithelial Cells. 2009 J Proteome Res. 2009, 8(8):3852-61, (Co-first author)

Zhao R*, Ding SJ*, Shen YF, Camp DG, Livesay EA, Udseth H, Smith RD. Automated metal-free nanoscale RPLC system for efficient analysis of phosphopeptides. J Chromatography B. 2009, 877(8-9):663-70, (Co-first author)

Ding SJ, Carr J, Carlson JE, Xue WH, Li YF, Schopfer LM, Li B, Nachon F, Asojo O, Thompson CM, Hinrichs SH, Masson P, Lockridge O. Five tyrosines and two serines in human albumin are labeled by the organophosphorus agent FP-biotin. Chem Res Toxicol. 2008 21, 1787-94

Ding SJ, Wang YC, Jacobs JM, Qian WJ, Yang F, Tolmachev AV, Du XX, Strittmatter EF, Moore RJ, Monroe ME, Purvine SO, Luo QZ, Waters K, Adkins JN, Camp DG, Klemke RL, Smith RD. Quantitative Phosphoproteome Analysis of Lysophosphatidic Acid Induced Chemotaxis applying Dual-step 18O Labeling Coupled with Immobilized Metal-ion Affinity Chromatography. J Proteome Res. 2008 7:4215-4224

Wang Y*, Ding SJ*, Wang W, Jacobs JM, Qian WJ, Moore RJ, Yang F, Camp DG 2nd, Smith RD, Klemke RL. Profiling signaling polarity in chemotactic cells. Proc Natl Acad Sci U S A. 2007 104, 8328-33. (Co-first author)

Ding SJ, Qian WJ, Smith RD. Quantitative proteomic approaches for studying phosphotyrosine signaling. Expert Rev Proteomics. 2007 4, 13-23.

Ding SJ, Li Y, Shao XX, Zhou H, Zeng R, Tang ZY, Xia QC. Proteome analysis of hepatocellular carcinoma cell strains, MHCC97-H and MHCC97-L, with different metastasis potentials. Proteomics. 2004, 4, 982-94.

Ding SJ, Li Y, Tan YX, Jiang MR, Tian B, Liu YK, Shao XX, Ye SL, Wu JR, Zeng R, Wang HY, Tang ZY, Xia QC. From proteomic analysis to clinical significance: overexpression of cytokeratin 19 correlates with hepatocellular carcinoma metastasis. Mol Cell Proteomics. 2004, 3, 73-81. (Cover)

For a detailed list of publications, click here.

Shi-Jian Ding, Ph.D.
Dr. Shi-Jian Ding
Email Address
dings@unmc.edu

Mailing Address
985900 Nebraska Medical Center
Omaha, NE 68198-5900

Office Address
DRC2 8064

Laboratory Address
DRC2 8014

Phone Numbers
Office: 402-559-4183
Lab: 402-559-6076

Fax
402-559-5900

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