Pathology and Microbiology (PAMM) electives


Course Number, Title, and Synopsis

Course Details

PAMM 830. Clinical Laboratory Management I
This course introduces the theory, practical application and evaluation of laboratory management principles in health care and laboratory information systems, research, educational methodology, quality control, ethics, laboratory operations, and laboratory accreditation standards. Opportunities for building critical thinking, problem-solving, teamwork, communication, professionalism, research, management, and leadership skills are provided. Course director: K. Honeycutt

Prereq: Enrolled in MS in PAMM Program focused on CLS training.
Instructor permission 
Offered: Fall (annually) 
Credits: 3 

PAMM 857. Medical Immunology 
A study of the basic concepts and mechanisms of modern immunology with discussion of the applications of these principles to the study of diseases. Course director: T. McDonald

Prereq: None
Offered: Fall (annually) 
Credits: 2 
PAMM 871. Antibiotics: Mechanisms of Action and Resistance 
This course is designed to give students an in-depth understanding of how antibiotics inhibit growth in bacterial cells. Genetics of the mechanisms of resistance to multiple classes of antibiotics within both gram-negative and -positive bacteria will be covered extensively. In addition, pros and cons of various antimicrobial-resistance testing methodologies will be assessed and discussed. Course director: P. Fey
Prereq: None. PAMM 898 (Microbiology) is suggested. Enrollment needs instructor approval.
Offered: Spring (every 2-3 years)
Credits: 3
PAMM 873. Introduction to Computerized Genetic Sequence Analysis
Fundamentals of using online search techniques for the analysis of genetic sequence databases. The course will be taught in UNMC computer clusters by lecture and by the completion of assignments using computer programs available on campus. Programming experience is not required. Also known as Bioc 873. Course director: D. Bastola 
Prereq: Intro to Computational Molecular Biology, undergraduate course in biochemistry or molecular biology, or permission of instructor.
Offered: Spring
Credits: 2 
PAMM 880. Principles and Methodologies in Cancer Research 
The course surveys the biology and biochemical mechanisms underlying cancer development, prevention, and therapy. Also listed as BIOC 841, PHAR 880, or PHSC 880. Course director: X. Luo, R. Lewis. 
 Prereq: BRTP 821, 822, 823 and 824 or equivalent, permission of instructor.
Offered: Fall (annually)
Credits: 3 
PAMM 890. The Molecular Biology of Viruses  
The principles of molecular biology and their application to the study of virology will be discussed in seminar format, drawing largely on the current literature. The contributions of virology to the understanding of general mechanisms of pathogenesis will be discussed. Course director: N. Chapman.

Offered: Fall (every 2-3 years)

PAMM 898. Bacterial Genetics  
This course will cover the principles of bacterial genetics including genome structure, DNA replication and recombination, transcription and translation, as well as quorum sensing and environmental sensing. Course director: K. Bayles

Prerequisite: Permission of instructor.
Offered: Spring (every 2 years)
Credits: 3

PAMM 902. Protein Mass Spectrometry and Proteomics
This course explores the concept and history of proteomics (2 hrs), basic components of mass spectrometry (4), protein identification and quantification techniques (6), proteomic analysis of post-translational modifications (4 hrs), protein-protein interactions (2 hrs) and cellular organelles (2 hrs) as well as proteomics in medical applications (6) . Laboratory work of identifying cheese proteins using mass spectrometry will be included (6). 
Prereq: BRTP 821 and instructor permission required
Offered: Fall (variable)
Credits: 2 
PAMM 910. Bacterial Pathogenesis   
This course explores the genetic mechanisms of bacterial pathogenesis in both gram-positive and gram-negative bacteria as well as the immunological response of the host to these pathogens. Particular importance will be placed on major pathogens including Staphylococcus aureus, Salmonella enterica, pathogenic Escherichia coli, and Mycobacterium tuberculosis. However, lesser studied pathogens will also be discussed. Course director: P. Fey
Prerequisite: BRTP 821-824, Permission of instructor. 
Offered: Variable
Credits: 3 
PAMM 930. Neuroimmunology  (Also listed as PHAR 930)
The objective of this course is to provide essential knowledge towards a better understanding of the principles of Neuroimmunology and Pharmacology as they apply to the pathogenesis and pharmacotherapeutics of neurodegenerative disorders and disorders in which the immune system is implicated. The course is designed for in depth study of neurobiology, neuroimmunology, neuropharmacology, immunotherapy, and neurodegenerative disorders.  The course is based on the textbook Neuroimmune Pharmacology, edited by Ikezu and Gendelman. This is an essential course for the Neuroscience Track in the Department of Pharmacology and Experimental Neuroscience. Course director: Lee Mosley. 
Prereq: Second semester of 2nd and 3rd year graduate students who have completed BRTP 821/822, 824, and one GCBA Neurobiology course (922 or 932) or M.D./Ph.D. students fully engaged in their graduate studies. A background in immunology, such as a Medical Immunology course is highly recommended.
Offered: Spring
Credits: 3 
PAMM 940. Molecular Basis of Human Disease  
Beginning with an overview of human genetics, including classical and contemporary methods of genetic analysis, the course explores the relationship between genetic diversity and disease. Human biochemical genetics and inborn errors of metabolism illustrate how specific phenotypes result from specific gene changes. Genetice polymorphism, selection and fitness are also explored with regard to the interactions among human populations and with the environment. Course directors: S. Carson and M. Godfrey 
Prerequisite: Permission of instructor, 800-level Biochemistry, and BRTP 821 or 822.
Offered: Spring (every other) 
Credits: 3 
PAMM 945. Stem Cell Biology  
This course is designed for an in depth study of the basic science in stem cell biology as well as clinical applications of stem cells. Special emphasis will be on embryonic stem cells, adult stem cells, and stem cell plasticity. Course director: N Sarvetnick.  
Offered: Fall and spring (annually).
Credits: 1 

PAMM 950 Special Topic Series

PAMM 950. Special Topics: Principles of Immunology
This course includes the basic and fundamental principles of immunology relevant for the study and research in immunology, microbiology, virology, infectious diseases, and cancer biology. Course directors: D. Johnson and R. Singh
Prerequisites: BRTP 821-824
Credits: 2 
PAMM 950. Special Topics: Topics in Staphylococcal Biology  
This course familiarizes students with known aspects of staphylococcal biology (including Staphylococcus aureus and coagulase-negative staphylococci) including pathogenesis, metabolism, regulatory pathways, and biofilm. It is designed as a literature and discussion based course.
Prerequisite: Permission of instructor.
Credits: 2
PAMM 950. Special Topics: Virology for the Rest of Us
The purpose of this course is to prepare students to deal with current issues in virology.  Concepts of historical and current challenges in human health involving virology will be introduced and discussed.   
Prerequisites: PharmD Medical Microbiology or CPH 623 Infectious Disease Epidemiology or equivalent. 
Credits: 3 
PAMM 955. Advanced Immunobiology     
Conceptual study of cellular and biomolecular immunology. Includes mechanisms of immune recognition, regulatory and effector functions, interleukins and clinical immunology, with discussion of current literature. Course director: D. Johnson
Prerequisite: Permission of instructor, and BRTP 821, 822, 823, 824 and PAMM 950A.
Offered: Spring (every other).
PAMM 956. Advanced Immunology Laboratory  
Techniques of immunology with emphasis on T and B cell identification, studies of lymphokine activities, lymphocyte effector function, monoclonal antibodies, and biotechnology. Lab 4.  Course director: D. Johnson
Prerequisite: Prior or concurrent to PAMM 955.
Credits: 2 
PAMM 970. Seminar
Course director: R. Singh and K. Bayles 
Prerequisite: Permission of instructor.
PAMM 992. Advanced Topics in Mircobiology-Biomedical Literature 
Study of the current scientific literature with emphasis on new and emerging diseases, treatment, and technologies. Course director: C. Kuszynski 
Prerequisite: Permission of instructor.
Offered: Fall and spring (annually). 
Credits: 1 

 Biostatistic (BIOS) & Bioinformatics (BIOI/UNO) Electives 

BIOS 806. Biostatistics I
This course is designed to prepare the graduate student to understand and apply biostatistical methods needed in the design and analysis of biomedical and public health investigations. The major topics to be covered include types of data, descriptive statistics and plots, theoretical distributions, probability, estimation, hypothesis testing, and one-way analysis of variance. A brief introduction to correlation and univariate linear regression will also be given. The course is intended for graduate students and health professionals interested in the design and analysis of biomedical or public health studies.
 Credits: 3
BIOI 8866. Bioinformatics Algorithms
The main objective of this course is to provide an organized forum for learning about recent developments in Bioinformatics, particularly, from the algorithmic standpoint. The course will present basic algorithmic concepts in Bioinformatics and show how they are connected to molecular biology and biotechnology. Standard topics in the field such as restriction mapping, motif finding, sequence comparison, and database search will be covered. The course will also address problems like next generation sequencing, DNA arrays, genome rearrangements and biological networks.
Prerequisite: CSCI 3320 and BIOL 1450 or permission of instructor.
3 credits