Tammy L. Kielian, PhD

Department Affiliations
Professor
Choudari Kommineni, DVM, PhD Professor of Pathology (2014)

Interests
Host-pathogen interactions, immunology, neuroimmunology, translational therapeutics
Dr. Kielian's laboratory for more details of her research. 
 
Education and Training
BS, University of Nebraska-Lincoln, Lincoln NE (Biological Sciences), 1991
MS, Kansas State University, Manhattan, KS (Immunology), 1994
PhD, University of Kansas Medical Center, Kansas City, KS (Microbiology), 1998
Post-doctoral training, Dartmouth Medical School, Lebanon, NH (Neuroimmunology), 1998-2001

Teaching Activities
Graduate students - Graduate student mentor
Advanced Immunology (PATH 955)
Bacterial Pathogenesis (PAMM 950)
Receptors and Cell Signaling (PHAR 901)

National Activities
Program Committee, 2021 International Society for Neurochemistry (ISN)-Asian Pacific Society of Neurochemistry (APSN) Meeting, Kyoto, Japan, 2020

Program Committee, 3^rd Americas School of Neuroimmunology (ASNI), University of Montreal Hospital Research Centre, Canada, 2019
Scientific Program Committee, 2020 American Society for Neurochemistry (ASN) Annual meeting, St. Louis, MO, 2019
Co-Chair, Gordon Research Conference on Staphylococcal Diseases, Lucca (Barga), Italy, 2017
Chair, FASEB Scientific Research Conference on Neuroimmunology, Big Sky, MT, 2016
Scientific Program Committee, 17^th International Symposium on Staphylococci and Staphylococcal Infections (ISSSI), Seoul, Korea, 2016
Chair, NIH/NINDS NST-2 review panel for MD/PhD and K99/R00 applications, 2014-2016 and Full Member 2011-2014
Deputy Chief Editor and Member of Editorial Board, Journal of Neurochemistry
Editorial Board, Journal of Neuroinflammation
Jordi Folch Pi Memorial Award from the American Society for Neurochemistry (ASN) for outstanding contributions to Neuroscience Research 

Local Awards
Outstanding Mentor of Graduate Students Award, University of Nebraska Medical Center Faculty Senate, 2022
Department of Pathology and Microbiology Outstanding Mentor of Junior Research Faculty Award, University of Nebraska Medical Center, 2019
11^th Science Laureate, University of Nebraska Medical Center, 2016
Graduate Student Association Distinguished Mentor Award, University of Nebraska Medical Center, 2015
UNeMed Innovator of the Year Award, University of Nebraska Medical Center, 2015
UNeMed Emerging Inventor award, University of Nebraska Medical Center, 2012
UNMC Distinguished Scientist award, University of Nebraska Medical Center, 2010 

Notable Publications

Google Scholar

Recent Published Work (from a total of 135 publications)

Van Roy, Z. and Kielian, T. Exploring epigenetic reprogramming during central nervous system infection. Immunol. Reviews, 00: 1– 18. doi:10.1111/imr.13079, 2022

Heim, C.E., Bosch, M.E., Yamada, K.J., Aldrich, A.L., Chaudhari, S.S., Klinkebiel, D., Gries, C.M., Alqarzaee, A.A., Li, Y., Thomas, V.C., Seto, E., Karpf, A.R., and Kielian, T. Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogram the host immune response during persistent infection. Nature Microbiol., 5:1271-1284, 2020.

Bosch, M.E.*, Bertrand, B.P.*, Heim, C.E., Chaudhari, S.S., Aldrich, A.L., Thomas, V.C., and Kielian, T. Staphylococcus aureus ATP synthase promotes biofilm persistence by influencing innate immunity. mBio, 11(5):e01581-20, 2020. *Equal contributions.

Aldrich, A.*, Horn, C.M.*, Heim, C.E., Korshoj, L.E., and Kielian, T. Transcriptional diversity and niche-specific distribution of leukocyte populations during Staphylococcus aureus craniotomy-associated biofilm infection. J. Immunol., 206:751-765, 2021. *Equal contributions.

Aldrich, A., Heim, C.E., Shi, W., Fallet, R.W., Duan, B., and Kielian, T. TLR2 and caspase-1 signaling are critical for bacterial containment but not clearance during craniotomy-associated biofilm infection. J. Neuroinflamm., 14;17(1):114, 2020.

Yamada, K.J., Heim, C.E., Xi, X., Attri, K.S., Wang, D., Zhang, W., Singh, P.K., Bronich, T.K., and Kielian, T. Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance, PLoS Path., 16(3):e1008354, 2020. PMID: 32142554

Aldrich A., Kuss, M., Duan, B., and Kielian, T. 3D bioprinted scaffolds containing viable macrophages and antibiotics promote clearance of Staphylococcus aureus craniotomy-associated biofilm infection, ACS Applied Materials & Interfaces, 11:12298-12307, 2019.

Yamada, K.J. and Kielian, T. Biofilm-leukocyte cross-talk: impact on immune polarization and immunometabolism. J. Innate Immun., 11:280-288, 2019.