Weiwei Zhang, PhD

Department Affiliations
Associate Professor
Clinical Genomics Bioinformatics Analyst
Director of Clinical Molecular Bioinformatics

Interests
Next generation sequencing, genomic data analysis, clinical informatics, analysis pipeline development, data science

Education and Training
PhD (Bioinformatics), University of Nebraska Medical Center, 2015
MS (Mathematics), University of Nebraska at Omaha, 2010
MS (Measuring and Testing Techniques and Instruments), Changchun University of Science and Technology, China, 2008
BS (Computer Science and Technology), Changchun University, China, 2005

Teaching Activities
Course director, PAMM825/BMI825 Introduction to R programming for Biomedicine
Instructor and content committee, Association for Molecular Pathology GetAMPed/Outreach course: Introduction to Bioinformatics Pipeline & Data Analysis
Content Committee, Association for Molecular Pathology Certificate Program: Next Generation Bioinformatics: Beyond Simple Variant Calling
Involved in sequencing and analysis related education
Core faculty, Molecular Genomics Pathology fellowship program

Committee Member
Cheng Wang, PhD student
Stephen Luebker, PhD student
Sahil Sethi, PhD student
Kalluchi, Achyuth, PhD student
Chen Zhang, PhD student
Mehnaz Tabassum, PhD student

National Activities
Member, Association for molecular pathology
Informatics Training & Education Committee Representative, Association for molecular pathology
Informatics Clinical Practice Committee Representative, Association for molecular pathology
Lymphoma/Leukemia Molecular Profiling Project
Reviewer panel member, Current Bioinformatics
Reviewer, The Journal of Molecular Diagnostics
Reviewer, Blood Advances
Reviewer, BioMed Research International
Reviewer, Human Mutation
Reviewer, Current Oncology
Reviewer, Diagnostics
Young Investigator Award Judging for AMP annual meeting
The Open Science Data Cloud Partnerships for International Research and Education at University of Amsterdam Award
High Performance Computing in the Life/Medical Sciences at the Virginia Bioinformatics Institute Award

Notable Publications

Hatipoğlu T, Esmeray E, Hu X, Yuan H, Danyeli A, Şeyhanlı A, Süzek T, Zhang W, Akman B, Olgun A, Özkal S, Alacacıoğlu I, Özcan M, You H, Küçük C. Plasma concentrations and cancer-associated mutations in cell-free circulating DNA of treatment-naive follicular lymphoma for improved non-invasive diagnosis and prognosis. Frontiers in Oncology. 2022

Abdulla F, Zhang W, Wu X, Honda K, Qin H, Querfeld C, Zain J, Rosen S, Chan J, Parekh, SongJ. Genomic Analysis of Primary Cutaneous CD30-positive Lymphoproliferative Disorders. Journal of Investigative Dermatology. 2022. 

Ibrar W*, Zhang W*, Cox J, Cushman-Vokoun A, Fu K, Greiner T, Yuan J. The Utility of a Myeloid Mutation Panel for Diagnosis of Myelodysplastic Syndrome and Myelodysplastic/myeloproliferative Neoplasm. International Journal of Laboratory Hematology. 2021. 

Chapman J, Bouska A, Zhang W, Alderuccio J, Lossos L, Rimsza L, Maguire A, Yi S, Chang WC, Vega F, Song J. EBV-Positive HIV-associated Diffuse Large B cell lymphomas are Characterized by JAK/STAT (STAT3) Pathway Mutations and Unique Clinicopathologic Features. British Journal of Haematology. 2021. 

Chaudhary S, Brown N, Song J, Yang L, Skrabek P, Nasr M, Wong J, Bedell V, Murata-Collins J, Kochan L, Li J, Zhang W, Chan W, Weisenburger D, Perry A. Relative frequency and clinicopathologic characteristics of MYC-rearranged follicular lymphoma. Human Pathology. 2021.

Wang C, Althof P, Bi C, Zhang W, Bouska A, Jiang N, Iqbal J, Vose J, Sanmann J, Fu K. A novel MYC-non-IG fusion in refractory diffuse large B-cell lymphoma. British Journal of Haematology. 2020.

Song J, Egan C, Bouska A, Zhang W, Gong Q, Venkataraman G, Herrera A, Chen L, Ottesen R, Niland J, Bedell V, Valle-Catuna M, Murata-Collins J, Weisenburger D, Iqbal J, Jaffe E, Chan W. Genomic characterization of diffuse large B-cell lymphoma transformation of nodular lymphocyte predominant Hodgkin lymphoma. Leukemia. 2020.

Holst J, Plesner T, Pedersen M, Frederiksen H, Moller M, Clausen M, Hansen M, Hamilton-Dutoit S, Norgaard P, Johansen P, Eberlein T, Mortensen B, Mathiasen G, Ovlisen A, Wang R, Wang C, Zhang W, Ommen H, Stentoft J, Ludvigsen M, Tam W, Chan W, Inghirami G, d’Amore F.  Myeloproliferative and lymphoproliferative malignancies occurring in the same patient: A nationwide discovery cohort. Haematologica. 2019.

Abdalhamid B, Mccutchen EL, Bouska AC, Zhang W, Loeck B, Hinrichs SH, Iwen PC. Whole genome sequencing to characterize shiga toxin-producing Escherichia coli O26 in a public health setting. Journal of infection and public health. 2019.

Li W, Bi C, Han Y, Tian T, Wang X, Bao H, Xu X, Zhang X, Liu L, Zhang W, Gao H, Wang H, Zhang H, Meng B, Wang X, Fu K. Targeting EZH1/2 induces cell cycle arrest and inhibits cell proliferation through reactivation of p57^CDKN1C and TP53INP1 in mantle cell lymphoma. Cancer Biology & Medicine. 2019.

Zhang X, Bi C, Lu T, Zhang W, Yue T, Wang C, Tian T, Zhang X, Huang Y, Lunning M, Hao X, Brown L, Devine W, Vose J, Porco J, Fu K. Targeting Translation Initiation by Synthetic Rocaglates for Treating MYC-driven Lymphomas. Leukemia. 2019.

Heavican T, Bouska A, Yu J, Lone W, Amador C, Gong Q, Zhang W, Li Y, Dave B, Nairismagi M, Greiner T, Vose J, Weisenburger D, Lachel C, Wang C, Fu K, Stevens J, Lim S, Ong C, Gascoyne R, Missiaglia E, Lemonnier F, Haioun C, Hartmann S, Pedersen M, Laginestra M, Wilcox R, Teh B, Yoshida N, Ohshima K, Seto M, Rosenwald, Ott G, Campo E, Rimsza L, Jaffe E, Braziel R, d’Amore F, Inghirami G, Bertoni F, Leval L, Gaulard P, Staudt L, McKeithan T, Pileri S, Chan W, Iqbal J. Genetic Drivers of Oncogenic Pathways in Molecular Subgroups of Peripheral T-Cell Lymphoma. Blood. 2019.

Zhang W, Wang C, Zhang X. Mutplot: an easy-to-use online tool for plotting complex mutation data with flexibility. PLOS ONE. 2019.

Luebker S, Zhang W, Koepsell S. Comparing the genomes of cutaneous melanoma tumors to commercially available cell lines. Oncotarget. 2017.

Gong Q*, Wang C*, Zhang W*, Iqbal J, Hu Y, Greiner T, Cornish A, Kim J, Rabadan R, Abate F, Wang X, Inghirami G, McKeithan T, Chan WC. Assessment of T-cell receptor repertoire and clonal expansion in peripheral T-cell lymphoma using RNA-seq data. Scientific reports. 2017.

Zheng M*, Perry AM*, Bierman P, Loberiza F, Nasr MR, Szwajcer D, Del Bigio MR, Smith LM, Zhang W, Greiner TC. Frequency of MYD88 and CD79B Mutations, and MGMT Methylation in Primary Central Nervous System Diffuse Large B-cell Lymphoma. Neuropathology. 2017.

Bouska A*, Bi C*, Lone W*, Zhang W, Kedwaii A, Heavican T, Lachel C, Yu J, Ferro RA, Eldorghamy N, Greiner TC, Vose JM, Weisenburger DD, Gascoyne RD, Rosenwald A, Ott G, Campo E, Rimsza LM, Jaffe ES, Braziel RM, Siebert R, Miles RR, Dave S, Reddy A, Delabie J, Staudt LM, Song JY, McKeithan TW, Fu K, Green MR, Chang WC, Iqbal J. Genomic features of High Grade B-cell Lymphoma  with BL Signature Identifies a Potential Therapeutic Target. Blood. 2017.

Bouska A*, Zhang W*, Gong Q*, Iqbal J, Scuto A, Vose J, Ludvigsen M, Fitzgibbon J, Fu K, Weisenburger DD, Greiner TC, Gascoyne RD, Rosenwald A, Ott G, Campo E, Rimsza LM, Delabie J, Jaffe ES, Braziel RM, Connors JM, Wu CI, Staudt LM, D‘Amore F, McKeithan TW, Chan WC. Combined copy number and mutation analysis identifies oncogenic pathways associated with transformation of follicular lymphoma. Leukemia. 2016

Rohr J; Guo S; Huo J; Bouska A; Lachel CM; Li Y; Simone P; Zhang W; Gong Q; Wang C; Cannon A; Rosenwald A; Gascoyne R; Fu K; Greiner TC; Weisenberger DD; Vose J; Staudt L; Xiao W; Berger F; Borgstahl G; Davis S; McKeithan T; Iqbal J; Chan WC. Recurrent activating mutations of CD28 in peripheral T-cell lymphomas. Leukemia. 2015

Wang C; McKeithan TW; Gong Q; Zhang W; Bouska A; Rosenwald A; Gascoyne RD; Wu X; Wang J; Muhammad Z; Jiang B; Rohr J; Cannon A; Steidl C; Fu K; Li Y; Hung S; Weisenberger DD; Greiner TC; Smith L; Ott G; Rogan EG; Staudt LM; Vose J; Iqbal J; Chan WC. IDH2R172 mutations define a unique subgroup of patients with angioimmunoblastic T-cell lymphoma. Blood. Vol. 126 (15): p. 1741-1752, 2015

For a detailed list of publications, click here.