Javeed Iqbal, Ph.D.

Department Affiliations
Assistant Professor

Research interest
Molecular signatures to improve diagnosis and outcome prediction in Non-Hodgkin’s Lymphoma, Gene expression profiling and pathway targeted therapy in peripheral T-cell lymphoma, Characterization of key molecular signatures in natural killer cell malignancies

Education
B.Sc., (Honors) Biochemistry, AMU, Aligarh, India;
M.Sc., Biochemistry, AMU, Aligarh, India;
Ph.D., Hans Knoll Institute, Friedrich-Schiller-Universität Jena , Germany;
Master’s Fellowship Research Training, National Institute of Immunology (NII), India;
Junior Research Fellow, Institute of Genomics and Integrative Biology (IGIB) New Delhi-India;
Pre-doctoral fellowship, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Indian Institute of Sciences (IISc); Bangalore, India;
Postdoctoral fellowship, Pathology and Microbiology, UNMC, Omaha, NE, USA

Notable Publications

Iqbal J, Weisenburger DD, Chowdhury A, Tsai MY, Srivastava G, Greiner TC, Kucuk C, Deffenbacher K, Vose J, Smith L, Au WY, Nakamura S, Seto M, Delabie J, Berger F, Loong F, Ko YH, Sng I, Liu X, Loughran TP, Armitage J, Chan WC, International Peripheral T-cell Lymphoma Project. Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic γδ T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro. Leukemia. 2011 Feb;25(2):348-58. doi: 10.1038/leu.2010.255. Epub 2010 Nov 5. Erratum in: Leukemia. 2011 Aug;25(8):1377. PubMed PMID: 21052088.

Deffenbacher KE, Iqbal J, Liu Z, Fu K, Chan WC. Recurrent chromosomal alterations in molecularly classified AIDS-related lymphomas: an integrated analysis of DNA copy number and gene expression. J Acquir Immune Defic Syndr. 2010 May 1;54(1):18-26. doi: 10.1097/QAI.0b013e3181d3d9eb. PubMed PMID: 20216076.

Steidl C, Lee T, Shah SP, Farinha P, Han G, Nayar T, Delaney A, Jones SJ, Iqbal J, Weisenburger DD, Bast MA, Rosenwald A, Muller-Hermelink HK, Rimsza LM, Campo E, Delabie J, Braziel RM, Cook JR, Tubbs RR, Jaffe ES, Lenz G, Connors JM, Staudt LM, Chan WC, Gascoyne RD. Tumor-associated macrophages and survival in classic Hodgkin's lymphoma. N Engl J Med. 2010 Mar 11;362(10):875-85. doi: 10.1056/NEJMoa0905680. PubMed PMID: 20220182; PubMed Central PMCID: PMC2897174.

Iqbal J, Weisenburger DD, Greiner TC, Vose JM, McKeithan T, Kucuk C, Geng H, Deffenbacher K, Smith L, Dybkaer K, Nakamura S, Seto M, Delabie J, Berger F, Loong F, Au WY, Ko YH, Sng I, Armitage JO, Chan WC; International Peripheral T-Cell Lymphoma Project. Molecular signatures to improve diagnosis in peripheralT-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma. Blood. 2010 Feb 4;115(5):1026-36. doi: 10.1182/blood-2009-06-227579. Epub 2009 Nov 18. PubMed PMID: 19965671; PubMed Central PMCID: PMC2817630.

Iqbal J, Kucuk C, Deleeuw RJ, Srivastava G, Tam W, Geng H, Klinkebiel D, Christman JK, Patel K, Cao K, Shen L, Dybkaer K, Tsui IF, Ali H, Shimizu N, Au WY, Lam WL, Chan WC. Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies. Leukemia.2009;23(6):1139-51.

Georg Lenz, George Wright, Sandeep S. Dave, Wenming Xiao, John Powell, Hong Zhao, Weihong Xu, Bruce Tan, Neta Goldschmidt, Javeed Iqbal, Julie Vose et.al. Stromal gene signatures in large-B-cell lymphomas. “ N Engl J Med. 2008, 7;359(22):2313-23.

Francesco d’Amore, Eric Chan, Javeed Iqbal, Huimin Geng, Ken Young,* Li Xiao, Michelle M. Hess, Warren G. Sanger, Lynette Smith, Carsten Wiuf, Oskar Hagberg*, Kai Fu, Wing C. Chan, and Bhavana J. Dave. Clonal evolution in t(14;18)-positive follicular lymphoma, evidence for multiple common pathways and frequent parallel clonal evolution Clin Cancer Res. 2008 Nov 15;14(22):7180-7.

Iqbal J, Greiner TC, Patel K, Dave BJ, Smith L, Ji J, Wright G, Sanger WG, Pickering DL, Jain S, Horsman DE, Shen Y, Fu K, Weisenburger DD, Hans CP, Campo E, Gascoyne RD, Rosenwald A, Jaffe ES, Delabie J, Rimsza L, Ott G, Muller-Hermelink HK, Connors JM, Vose JM, McKeithan T, Staudt LM, Chan WC. Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma. Leukemia. 2007;21:2332-2343.

Javeed Iqbal, Vishala N, Douglas E. Horsman, Andreas Rosenwald, et.al: BCL2 is significant prognostic factor in activated-B-cell like lymphoma, but not in germinal-center– B-cell like lymphoma. J Clinical Oncology 2006; 24(6):961-8.

Yulei Shen, J. Iqbal, James Z. Huang, Guimei Zhou, Wing C. Chan: BCL2 protein expression parallels its mRNA level in normal and malignant B cells, Blood 2004;104:2936-9.

For a detailed list of publications, click here.

Javeed Iqbal, Ph.D.
Dr. Javeed Iqbal
Email Address

jiqbal@unmc.edu

Mailing Address
987660 Nebraska Medical Center
Omaha, NE 68198-7660

Laboratory Address
LTC 11715

Phone Numbers
402-559-7753

Fax
402-559-7716

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