Javeed Iqbal, Ph.D.

Department Affiliations
Assistant Professor

Research interest
Molecular signatures to improve diagnosis and outcome prediction in Non-Hodgkin’s Lymphoma, Gene expression profiling and pathway targeted therapy in peripheral T-cell lymphoma, Characterization of key molecular signatures in natural killer cell malignancies

Education
B.Sc., (Honors) Biochemistry, AMU, Aligarh, India;
M.Sc., Biochemistry, AMU, Aligarh, India;
Ph.D., Hans Knoll Institute, Friedrich-Schiller-Universität Jena , Germany;
Master’s Fellowship Research Training, National Institute of Immunology (NII), India;
Junior Research Fellow, Institute of Genomics and Integrative Biology (IGIB) New Delhi-India;
Pre-doctoral fellowship, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR), Indian Institute of Sciences (IISc); Bangalore, India;
Postdoctoral fellowship, Pathology and Microbiology, UNMC, Omaha, NE, USA

Notable Publications
Javeed Iqbal, Dennis D Weisenburger, Aparajita Chowdhury, Ming Ying Tsai et.al. Natural Killer Cell Lymphoma Shares Strikingly Similar Molecular Features with a group of Non Hepatosplenic T-Cell Lymphoma and is Highly Sensitive to a Novel Aurora Kinase A Inhibitor in vitro . Leukemia. [2010;in print]

Karen E. Deffenbacher, Javeed Iqbal, Zhongfeng Liu, Huimin Geng, Kai Fu, Louis M. Staudt, and Wing C. Chan, Recurrent Chromosomal Alterations in Molecularly Classified AIDS-Related Lymphomas through Integrated DNA Copy Number and Gene Expression Analysis J AIDS 2010, 54:18-26.

Christian Steidl, Tang Lee, Sohrab P. Shah, Pedro Farinha, Guangming Han,Tarun Nayar, Allen Delaney, Steven J. Jones, Javeed Iqbal, Dennis D.Weisenburger, et.al , Tumor-associated Macrophages and Survival in Classical Hodgkin lymphoma N Engl J Med. 2010 362:875-885.

Javeed Iqbal, Dennis D Weisenburger, Timothy C Greiner, Julie Vose, Timothy McKeithan, Can Kucuk, Huimin Geng, Karen Deffenbacher, Lynette Smith, Karen Dybkaer, Shigeo Nakamura, Masao Seto, Jan Delabie, Francoise Berger, Florence Loong, Wing Y Au, Young-Hyeh Ko, Ivy Sng, James Armitage and Wing C Chan, Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma Blood. 2010;115:1026-1036.

Iqbal J, Kucuk C, Deleeuw RJ, Srivastava G, Tam W, Geng H, Klinkebiel D, Christman JK, Patel K, Cao K, Shen L, Dybkaer K, Tsui IF, Ali H, Shimizu N, Au WY, Lam WL, Chan WC.Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies. Leukemia.2009;23(6):1139-51.

Georg Lenz, George Wright, Sandeep S. Dave, Wenming Xiao, John Powell, Hong Zhao, Weihong Xu, Bruce Tan, Neta Goldschmidt, Javeed Iqbal, Julie Vose et.al. Stromal gene signatures in large-B-cell lymphomas. “ N Engl J Med. 2008, 7;359(22):2313-23.

Francesco d’Amore, Eric Chan, Javeed Iqbal, Huimin Geng, Ken Young,* Li Xiao, Michelle M. Hess, Warren G. Sanger, Lynette Smith, Carsten Wiuf, Oskar Hagberg*, Kai Fu, Wing C. Chan, and Bhavana J. Dave. Clonal evolution in t(14;18)-positive follicular lymphoma, evidence for multiple common pathways and frequent parallel clonal evolution Clin Cancer Res. 2008 Nov 15;14(22):7180-7.

Iqbal J, Greiner TC, Patel K, Dave BJ, Smith L, Ji J, Wright G, Sanger WG, Pickering DL, Jain S, Horsman DE, Shen Y, Fu K, Weisenburger DD, Hans CP, Campo E, Gascoyne RD, Rosenwald A, Jaffe ES, Delabie J, Rimsza L, Ott G, Muller-Hermelink HK, Connors JM, Vose JM, McKeithan T, Staudt LM, Chan WC. Distinctive patterns of BCL6 molecular alterations and their functional consequences in different subgroups of diffuse large B-cell lymphoma. Leukemia. 2007;21:2332-2343.

Javeed Iqbal, Vishala N, Douglas E. Horsman, Andreas Rosenwald, et.al: BCL2 is significant prognostic factor in activated-B-cell like lymphoma, but not in germinal-center– B-cell like lymphoma. J Clinical Oncology 2006; 24(6):961-8.

Yulei Shen, J. Iqbal, James Z. Huang, Guimei Zhou, Wing C. Chan: BCL2 protein expression parallels its mRNA level in normal and malignant B cells, Blood 2004;104:2936-9.

For a detailed list of publications, click here.