Sonny L. Johansson, M.D., Ph.D.

Department Affiliations
Professor

Interests
Surgical Pathology (especially tumor pathology and urologic pathology), Urologic Pathology, Chemical Carcinogenesis

My research includes clinicopathological studies on urinary tract tumors, (bladder, ureter, renal pelvis), including papillary urothelial tumors as well as rare subtypes such as signet ring cell carcinoma, small cell carcinoma, lymphoepithelial carcinoma and micropapillary carcinoma. The WHO/ISUP consensus classification of bladder tumor grading was utilized in a large series of prospectively studied urinary bladder tumors and found to be prognostically valid. Studies have been performed in collaboration with urologists at Sahlgrenska University Hospital in Göteborg Sweden, and University of Tromsö Norway. Continued studies of interstitial cystitis has also been performed in collaboration with basic scientists and urologists at Sahlgrenska University Hospital. Collaborative studies on prostate cancer are ongoing with researchers in the department of biochemistry and urology and involves evaluation of various tumor markers using archival material and in vitro methods.

Education and Training
B.S., University of Göteborg, Zoology and Botany, 1965
M.D., University of Göteborg, 1972
Ph.D., University of Göteborg, Pathology, 1976
Residency in Anatomic Pathology, Sahlgrenska University Hospital, 1972-1976. St. Vincent Hospital, Worchester, Massachusetts, 1974-1975
Board certified in Anatomic pathology in Sweden, 1976 in the United States, 1989

Teaching Activities
Medical students - Genitourinary Pathology small group discussions and Laboratories
Residents - Anatomic pathology 
Cytotechnology Students - Urinary tract cytology and fine needle aspiration techniques

National Activities
Ad hoc reviewer: Cancer, Cancer Research, Clinical Toxicology, Fundamental and Applied Toxicology, International Journal of Cancer, JAMA, Journal of Urology, Laboratory Investigation, Toxicology, Toxicology and Applied Pharmacology.
 
Member of the ad hoc committee for the WHO/ISUP consensus classification of bladder tumors. Invited author for chapters on urothelial papilloma, papillary urothelial plasma of low malignant potential and low grade urothelial carcinoma in the WHO book on Pathology and Genetics of Tumors of the Urinary System and Male Genital Organs (2004).

Notable Publications
Holmäng S, Thomsen J, Johansson SL: Micropapillary carcinoma of the renal pelvis and ureter. J Urol. 175:463-467, 2006.

Sarosdy MF, Kahn PR, Ziffer MD, Love WR, Barkin J, Abara EO, Jansz K, Bridge JA, Johansson SL, Person D, Gibson J.  Use of the UroVysion Multi-target Fluorescent In-situ Hybridization Assay to Diagnose Bladder Cancer in Patients with Hematuria. J Urol. 176: 44-47, 2006.

Singh AP, Chauhan SC, Bafna S, Johansson SL, Smith LM, Moniaux N, Lin MF, Batra SK. Aberrant expression of transmembrane mucins, MUC1 and MUC4, in human prostate carcinomas. The Prostate. In press, 2006.

Chen SJ, Karan D, Johansson SL, Singh AP, Mimeault M, Batra SK, Lin MF: Prostate-derived factor (PDF) promotes the proliferation and tumorigenicity of human prostate cancer cells. In Press.

Holmäng S and Johansson SL:  The impact of diagnostic delay on survival in renal pelvic and ureteral cancer. Scand J Urol Nephral. In Press.

Chauhan SC, Singh AP, Ruiz F, Johansson SL, Jain M, Smith LM, Moniaux N, Batra SK:  Aberrant expression of MUC4 in ovarian carcinoma:  diagnostic significance alone and in combination with MUC1 and MUC16 (CA125).  Modern Pathology.  In Press.

Mimeault M, Venkatraman G, Moore E, Johansson SL, Henichart JP, Depreux P, Lin MF and Batra SK: Novel Combination Therapy Against Metastatic and Androgen-Independent Prostate Cancer Forms by Using a Combination of Gefitinib, Tamoxifen and Etoposide. Submitted.

Nemos C, Chakraborty S, Moniaux N, Parmender M, Johansson SL, Batra SK:  HPaf1 is Regulated by 17-β Estradiol and Required for progression in G1 and survival S/G2 Breast Cancer. Submitted.

Patrik A, Johansson SL, Holmäng S:  Prognostic factors in stage T1 bladder cancer:  Tumor pattern (solid or papillary) and vascular invasion are more important than depth of invasion.

Holmäng S, Amsler-Nordin S, Carlsson K, Holmberg E, Johansson SL:  Completeness and accurately of registration of renal pelvic and ureteral tumors in the Swedish Cancer Registry.

For a detailed list of publications, click here.

Sonny L. Johansson, M.D., Ph.D.
Dr. Sonny L. Johansson

Email Address
sjohanss@unmc.edu

Mailing Address
983135 Nebraska Medical Center
Omaha, NE 68198-3135

Office Location
MSB 3540

Phone Numbers
Office: 402-559-7681

Fax
402-559-6018

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