Tammy L. Kielian, Ph.D.

Department Affiliations
Professor

Interests
Immunology, Neuroimmunology, Infectious Diseases, Toll-like receptors (TLRs), Cytokine and chemokine biology
Dr. Kielian's laboratory for more details of her research. 
 
Education and Training
B.S., University of Nebraska-Lincoln, Lincoln NE (Biological Sciences), 1991
M.S., Kansas State University, Manhattan, KS (Immunology), 1994
Ph.D., Univ. Kansas Medical Center, Kansas City, KS (Microbiology), 1998
Post-doctoral training, Dartmouth Medical School, Lebanon, NH (Neuroimmunology), 1998-2001

Teaching Activities
Graduate students- Graduate student mentor
Advanced Immunology (PATH 955)
Bacterial Pathogenesis (PAMM 950)
Topics in Staphylococcal Biology (PAMM 950A)
Cell Signaling (BRTP 824)
Neuroimmunology (PHAR 930)
Receptors and Cell Signaling (PHAR 901)

National Activities
Handling Editor and Member of Editorial Board, Journal of Neurochemistry
Member of Editorial Board, Journal of Neuroinflammation
Member of American Society for Neurochemistry (ASN) Council
Member of American Society for Neurochemistry (ASN)Public Policy and Education Committee
Jordi Folch Pi Memorial Award from the American Society for Neurochemistry (ASN) for outstanding contributions to Neuroscience Research
Full and Ad-Hoc Member, NIH/CSR Clinical Neuroimmunology and Brain Tumors Study Section, 2002-2006
Scientific Advisory Board, UC Riverside Center for Glial NeuronalInteractions (CGNI)

Notable Publications
Microglial activation by Citrobacter koseri is mediated by TLR4- and MyD88-dependent pathways.Liu S, Kielian T. J Immunol. 2009 Nov 1;183(9):5537-47. Epub 2009 Oct 7.

Microglia in infectious diseases of the central nervous system. Mariani MM, Kielian T. J Neuroimmune Pharmacol. 2009 Dec;4(4):448-61. Epub 2009 Sep 2.

Toll-like receptors in brain abscess. Esen N, Kielian T. Curr Top Microbiol Immunol. 2009;336:41-61. Review.

Overview of toll-like receptors in the CNS. Kielian T. Curr Top Microbiol Immunol. 2009;336:1-14. Review.

MyD88 expression by CNS-resident cells is pivotal for eliciting protective immunity in brain abscesses. Garg S, Nichols JR, Esen N, Liu S, Phulwani NK, Syed MM, Wood WH, Zhang Y, Becker KG, Aldrich A, Kielian T. ASN Neuro. 2009 May 5;1(2).

TLR2 deficiency leads to increased Th17 infiltrates in experimental brain abscesses. Nichols JR, Aldrich AL, Mariani MM, Vidlak D, Esen N, Kielian T. J Immunol. 2009 Jun 1;182(11):7119-30.

TLR2 expression in astrocytes is induced by TNF-alpha- and NF-kappa B-dependent pathways. Phulwani NK, Esen N, Syed MM, Kielian T. J Immunol. 2008 Sep 15;181(6):3841-9.

Microglia and Astrocyte Activation by Toll-Like Receptor Ligands: Modulation by PPAR-gamma Agonists. Gurley C, Nichols J, Liu S, Phulwani NK, Esen N, Kielian T. PPAR Res. 2008;2008:453120.

Poly (ADP-ribose) polymerases (PARPs) 1-3 regulate astrocyte activation. Phulwani NK, Kielian T. J Neurochem. 2008 Jul;106(2):578-90. Epub 2008 Apr 10.

Glial connexins and gap junctions in CNS inflammation and disease. Kielian T. J Neurochem. 2008 Aug;106(3):1000-16. Epub 2008 Apr 10. Review.

For a detailed list of publications click here.