Tammy L. Kielian, Ph.D.

Department Affiliations
Professor

Interests
Immunology, Infectious Diseases, Neuroimmunology, Juvenile Batten Disease, Glial biology, Translational therapeutics
Dr. Kielian's laboratory for more details of her research. 
 
Education and Training
B.S., University of Nebraska-Lincoln, Lincoln NE (Biological Sciences), 1991
M.S., Kansas State University, Manhattan, KS (Immunology), 1994
Ph.D., Univ. Kansas Medical Center, Kansas City, KS (Microbiology), 1998
Post-doctoral training, Dartmouth Medical School, Lebanon, NH (Neuroimmunology), 1998-2001

Teaching Activities
Graduate students- Graduate student mentor
Advanced Immunology (PATH 955)
Bacterial Pathogenesis (PAMM 950)
Topics in Staphylococcal Biology (PAMM 950A)
Cell Signaling (BRTP 824)
Receptors and Cell Signaling (PHAR 901)

National Activities
Deputy Chief Editor and Member of Editorial Board, Journal of Neurochemistry 
Member of Editorial Board, Scientific Reports
Member of Editorial Board, Journal of Neuroinflammation 
Jordi Folch Pi Memorial Award from the American Society for Neurochemistry (ASN) for outstanding contributions to Neuroscience Research 
Full Member, NIH/NINDS NST-2 review panel for MD/PhD and K99/R00 applications, 2011-2015
Full and Ad-Hoc Member, NIH/CSR Clinical Neuroimmunology and Brain Tumors Study Section, 2002-2006
Scientific Advisory Board, UC Riverside Center for Glial NeuronalInteractions (CGNI)

Local Awards
UNeMed Emerging Inventor award, University of Nebraska Medical Center, 2012
UNMC Distinguished Scientist award, University of Nebraska Medical Center, 2010 

Notable Publications
Scherr, T.D*, Roux, C.R.*, Hanke, M.L., Angle, A., Dunman, P.D., and Kielian, T. Global transcriptome analysis of Staphylococcus aureus biofilms in response to innate immune cells, Infect. Immun., 81:4363 4376, 2013. *Equal contributions. Selected by Editors for journal “Spotlight” highlight.

Xiong, J. and Kielian, T. Microglia in Juvenile Neuronal Ceroid Lipofuscinosis (JNCL) are primed towards a proinflammatory phenotype. J. Neurochem., 127:245-258, 2013.

Cheatle, J.*, Aldrich, A.*, Thorell, W.E., Boska, M.D., and Kielian, T. Compartmentalization of immune responses during Staphylococcus aureus cranial bone flap infection. Am J. Pathology, 183:450-458, 2013.*Equal contributions.Image Selected for Journal Cover

Hanke, M.L.*, Heim, C.E.*, Angle, A., Sanderson, S., and Kielian, T. Targeting macrophage activation for the prevention and treatment of S. aureus biofilm infections, J. Immunol., 190:2159-2168, 2013.

Hanke, M.L. and Kielian, T. Loss of MyD88-dependent signaling influences alternative macrophage activation and fibrosis during Staphylococcus aureus biofilm infection. PLoS ONE, 7(8):e42476, 2012.

Hanke, M.L. and Kielian, T. Deciphering mechanisms of staphylococcal biofilm evasion of host immunity. Front. Cell. Inf. Microbio. 2:62, 2012.

Hanamsagar, R., Hanke, M.L., and Kielian, T. Toll-like receptor (TLR) and inflammasome actions in the central nervous system. Trends Immunol., 33:333-342, 2012.

Karpuk, N., Burkovetskaya, M., Fritz, T., Angle, A., and Kielian, T. Neuroinflammation leads to region-dependent alterations in astrocyte gap junction communication and hemichannel activity. J. Neurosci., 31:414-425, 2011.

Thurlow, L.R., Hanke, M.L., Fritz, T., Angle, A., Aldrich, A., Williams, S.H., Engebretsen, I.L., Bayles, K.W., Horswill, A.R., and Kielian, T. Staphylococcus aureus biofilms prevent macrophage phagocytosis and attenuate inflammation in vivoJ. Immunol., 186:6585-6596, 2011. Image Selected for Journal Cover

For a detailed list of publications click here.

 

Tammy L. Kielian, Ph.D.


Email Address
tkielian@unmc.edu

Mailing Address
985900 Nebraska Medical Center
Omaha, NE 68198-5900

Office Location
DRC2 7029

Laboratory Location
DRC2 7010/7014

Phone Numbers
Office: 402-559-8002
Lab: 402-559-8001

Fax
402-559-5900

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