Marilynn A. Larson, Ph.D.

Department Affiliations
Assistant Professor

Interests
Molecular Microbiology, Infectious Diseases, Pathogen Detection, Antibiotic Resistance and Discovery, DNA Replication and Regulation

Education and Training
Post-Doc., Pathology/Microbiology (Immunology), University of Nebraska Medical Center at Omaha, 2001
Ph.D., Biological Sciences (Microbial Physiology), University of Nebraska-Lincoln, 1999
M.A., Biology (Molecular Microbiology), University of Nebraska at Omaha, 1991
B.S., General Sciences, University of Nebraska-Lincoln, 1979
 
Notable Publications
Larson, M. A., Griep, M.A., Bressani, R., Chintakayala, K., Soultanas, P., and Hinrichs, S. H. (2010). Class-specific restrictions define primase interactions with DNA template and replicative helicase. Nucleic Acids Res. 38(20):7167-7178.

Bryant, K. A., Kinkead, L. C., Larson, M. A., Hinrichs, S. H., and Fey, P. D. 2010. Genetic analysis of the Staphylococcus epidermidis Macromolecular Synthesis Operon: Serp1129 is an ATP binding protein and sigA transcription is regulated by both σA- and σB-dependent promoters. BMC Microbiol. 10:8 (doi: 10.1186/1471-2180-10-8).

Chintakayala, K., Machon, C., Haroniti, A., Larson, M. A., Hinrichs, S. H., Griep, M. A., and Soultanas, P. 2009. Allosteric regulation of the primase (DnaG) activity by the clamp-loader (tau) in vitro. Mol. Microbiol. 68(2):360-371.

Larson, M. A., Bressani, R., Sayood, K., Corn, J. E., Berger, J. M., Griep, M. A., and Hinrichs, S. H. 2008. Hyperthermophilic Aquifex aeolicus initiates primer synthesis on a limited set of trinucleotides comprised of cytosines and guanines. Nucleic Acids Res. 36(16):5260-5269.

Chintakayala, K., Larson, M. A., Griep, M. A., Hinrichs, S. H., and Soultanas, P. 2008. Conserved residues of the C-terminal p16 domain of primase are involved in modulating the activity of the bacterial primosome. Mol. Microbiol. 68(2):360-371.

Koepsell, S. A., Larson, M. A., Frey, C. A., Hinrichs, S. H., and Griep, M. A. 2008. Staphylococcus aureus primase has higher initiation specificity, binds DNA stronger, but is less stimulated by its helicase than Escherichia coli primase. Mol. Microbiol. 68(6):1570-1582.

Griep, M. A., Blood, S., Larson, M. A., Koepsell S. A., and Hinrichs, S. H. 2007. Myricetin inhibits Escherichia coli DnaB helicase but not primase. Bioorg. Med. Chem. Lett. 15(22):7203-7208.

Chintakayala, K., Larson, M. A., Grainger, W. H., Scott, D. J., Griep, M. A., Hinrichs, S. H., and Soultanas, P. 2007. Domain swapping reveals that the C- and N-terminal domains of DnaG and DnaB, respectively, are functional homologues. Mol. Microbiol. 63(6):1629-1639.

Larson, M. A., Weber, A., and McDonald, T. L. 2006. Bovine serum amyloid A3 gene structure and promoter analysis: induced transcriptional expression by bacterial components and the hormone prolactin. Gene 380(2):104-110.

Koepsell, S. A., Larson, M. A., Griep, M. A., and Hinrichs, S. H. 2006. Staphylococcus aureus helicase but not Escherichia coli helicase stimulates S. aureus primase activity and maintains initiation specificity. J. Bacteriol. 188(13):4673-4680.

For a detailed list of publications, click here.

 

Marilynn A. Larson, Ph.D.
Dr. Marilynn A. Larson
Email Address
malarson@unmc.edu

Mailing Address
985900 Nebraska Medical Center
Omaha, NE 68198-5900

Office Location
DRC2 7036

Laboratory Location
DRC2 7046

Phone Numbers
Office: 402-559-9115
Lab: 402-559-7723

Fax
402-559-5900

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