Rakesh K. Singh, Ph.D.

Department Affiliations
Director, Department of Pathology and Microbiology Graduate Program

Tumor Growth and Metastasis, Angiogenesis, Tumor Immunology, Cytokine Biology
Please see Dr. Singh's laboratory webpage.
National Activities
Editorial Board Member: American Journal of Cancer Research; The Open System Biology Journal; The Open Circulation & Vascular Journal; The Open Breast Cancer Journal; Clinical Research and Regulatory Affairs; Frontiers in Biosciences   
National and International Grant Review Committee: Department of Defense Breast Cancer Research Program Grant review committee (Breast Cancer Peer Review Panel PBY1 and PBY-5); Cancer Research, UK, Project Grant Application Review Committee; Susan G. Komen Breast Cancer Foundation, Targeted Therapeutics-2 (TT-2) Grant Review Committee; European Research Council LS2 Review panel (Genetics, Genomics, Bioinformatics and Systems biology); Department of Defense Prostate Cancer Research Program Grant review committee (Peer Review Panel PBY-2); Medical Research Council, UK, Project Grant Application Review Committee; Biomedical Research Council, Grant application Review, Singapore; National Institutes of Health, Special Emphasis Panel/Scientific Review Group 2010/05 ZCA1 RPRB-K (M1)

Recent Publications
Singh S, Varney ML, Singh RK.  Host CXCR2-dependent regulation of melanoma growth, angiogenesis, and experimental lung metastasis.  Cancer Research (Priority Reports) 69:411-415, 2009. PubMed PMID: 19147552; PubMed Central PMCID: PMC2652477.

Futakuchi M, Nannuru KC, Sadanandam A, Varney ML, Nakao K, Asai K, Shirai T, Sato S and Singh RK: Transforming growth factor-b signaling at the tumor-bone interface promotes mammary tumor growth and osteolysis by enhancing RANKL-dependent osteoclast activation.  Cancer Science, 100: 71-81, 2009. PubMed PMID: 19038005.

Wilson TJ, Nannuru KC and Singh RK.  Cathepsin G recruits osteoclast precursors via proteolytic activation of PAR-1. Cancer Research. 69: 3188-3195, 2009. PubMed PMID: 19293192.

Singh S, Sadanandam A, Nannuru KC, Varney ML, Mayer-Ezell R, Bond R, Singh RK.  Small molecule antagonists for CXCR1 and CXCR2 inhibit human melanoma growth by decreasing cell proliferation, survival and angiogenesis.  Clinical Cancer Research, 15:2380-2386, 2009. PubMed PMID: 19293256.

Singh S, Nannuru KC, Sadanandam A, Varney ML and Singh RK.  CXCR1 and CXCR2 enhance human melanoma tumorigenesis, growth and invasion.  British J. Cancer, 100: 1638-1646, 2009. PubMed PMID: 19401689; PubMed Central PMCID: PMC2696769.

Nannuru KC, Futakuchi M, Sadanandam A, Wilson TJ, Varney ML, Myers KJ, Li X, Marcusson EG and Singh RK: Enhanced expression and shedding of receptor activator of NF-kB ligand (RANKL) during tumor-bone interaction potentiates mammary tumor induced osteolysis. Clinical and Experimental Metastasis, 26:797-808, 2009. PubMed PMID: 19590968.

Wilson TJ, Nannuru KC and Singh RK.  Cathepsin G-mediated Activation of Pro-MMP9 at the Tumor-Bone Interface Promotes TGF-β Signaling and Bone Destruction.  Molecular Cancer Research, 7:1224-1233, 2009. PubMed PMID: 19671689.

Singh S, Nannuru KC, Sadanandam A, Varney ML and Singh RK.  Small interfering RNA-mediated CXCR1 and CXCR2 knock-down inhibits melanoma tumor growth and invasion.  International J Cancer, 126:328-336, 2010. PubMed PMID: 19585580; PubMed Central PMCID: PMC2794956.

Sadanandam A, Varney ML, Singh S, Ashour AE, Moniaux N, Deb S, Lele SM, Batra SK, and Singh RK.  High gene expression of semaphorin 5A in pancreatic cancer is associated with tumor growth, invasion and metastasis. International J Cancer, PMID: 20073063, 2010 (E-publication). PubMed PMID: 20073063.

Nannuru KC, Futakuchi M, Varney ML, Vincent TM, Marcusson EG and Singh RK. Matrix metalloproteinase (MMP)-13 regulates mammary tumor-induced osteolysis by activating MMP9 and TGFβ signaling at the tumor-bone interface.  Cancer Res., 70:3494-3504, 2010. PubMed PMID: 20406980.

For a detailed list of publications, click here.

Rakesh K. Singh, Ph.D.
Dr. Rakesh K. Singh
Email Address

Mailing Address
985900 Nebraska Medical Center
Omaha, NE 68198-5900

Office Location
DRC2 7070

Laboratory Location
DRC2 7022

Phone Numbers
Office: 402-559-9949
Lab: 402-559-5580