Guangshun (Gus) Wang, Ph.D.

Department Affiliations
Assistant Professor

Interests
Host defense antimicrobial peptides, Structural bioinformatics, Biomolecular NMR

Please visit Dr. Wang's laboratory webpage for further information on his research.

Education and Training
B.S., Yangzhou University, 1985 (Chemistry)
M.S., Chinese Academy of Sciences, 1988 (Environmental Chemistry)
Ph.D., Simon Fraser University, 1997 (Biophysical Chemistry)
Postdoctoral fellow: Florida State University, 1997-1999 (Structural Biology);
National Institutes of Health, 1999-2002 (Protein NMR)

Notable Publications
Wang, G., Li, X & Zasloff, M. 2010. A database view of naturally occurring antimicrobial peptides: nomenclature, classification and amino acid sequence analysis. In Wang, G. (ed.) "Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies". CABI, Oxfordshire, UK, pp. 1-21.

Wu, W.K.K.#, Wang, G.#, Coffelt, S.B.#, Betancourt, A.M., Lee, C.W., Yu, J., Sung, J.J.Y., & Cho, C.H. 2010. Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications. Int. J. Cancer 127(8):1741-1747. #Equal contributions.

Wang, G. 2010. Database-aided prediction and design of novel antimicrobial peptides. In Wang, G. (ed.)
"Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies". CABI, Oxfordshire, UK,
pp. 72-86.

Wang, G., Watson, K.M., Peterkofsky, A. & Buckheit, R.W. Jr. 2010. Identification of novel human immunodeficiency virus type 1 inhibitory peptides based on the antimicrobial peptide database. Antimicrob. Agents Chemother. 54(3):1343-1346. PMCID: PMC2826022

Wang, G. 2010. Structural studies of antimicrobial peptides provide insight into their mechanisms of action. In Wang, G. (ed.) "Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies". CABI, Oxfordshire, UK, pp.141-168.

Wang, G. 2008. Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles. J. Biol. Chem. 283:32637-32643. PDB entry: 2K6O; BMRB entry: 15876.

Wang, G. 2007. Tool developments for structure-function studies of host defense peptides. Protein Pept. Lett. 14:57-69.

Li, Y., Li, X. & Wang, G. 2006. Cloning, expression, isotope labeling, and purification of human antimicrobial peptide LL-37 in Escherichia coli for NMR studies. Protein Exp. Purif. 47:498-505.

Li, X., Li, Y., Han, H-.Y., Miller, D.W. & Wang, G. 2006. Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. J. Am. Chem. Soc. 128:5776-5785. PDB entries: 2FBS; 2FBU; 2FCG.

Wang, Z. & Wang, G. 2004. APD: the antimicrobial peptide database. Nucleic Acids Res. 32:D590-D592. Web site http://aps.unmc.edu/AP/main.html; PMCID: PMC308759.

Books
Wang, G. (ed.) 2010. Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies. CABI, Oxfordshire, UK. ISBN 978-1845-9365-70.

For a detailed list of publications, click here.