Guangshun (Gus) Wang, Ph.D.

Department Affiliations
Assistant Professor

Interests
Host defense antimicrobial peptides, Structural bioinformatics, Biomolecular NMR

Please visit Dr. Wang's laboratory webpage for further information on his research.

Education and Training
B.S., Yangzhou University, 1985 (Chemistry)
M.S., Chinese Academy of Sciences, 1988 (Environmental Chemistry)
Ph.D., Simon Fraser University, 1997 (Biophysical Chemistry)
Postdoctoral fellow: Florida State University, 1997-1999 (Structural Biology);
National Institutes of Health, 1999-2002 (Protein NMR)

Notable Publications
Wang, G., Mishra, B., Epand, R.F., Epand, R.M. 2014. High-quality 3D structures shine light on antibacterial, anti-biofilm and antiviral activities of human cathelicidin LL-37 and its fragments. Biochim. Biophys. Acta, in press. 

Wang, G. 2013. Database-guided discovery of potent peptides to combat HIV-1 or Superbugs. Pharmaceuticals 6, 728-758. 

Mishra, B., Wang, G. 2012. Ab initio design of potent anti-MRSA peptides based on database filtering technology (DFT).J. Am. Chem. Soc. 134, 12426-12429.

Wang, G., Epand, R.F., Mishra, B., Lushnikova, T., Thomas, V.C., Bayles, K.W., Epand, R. 2012. Decoding the functional roles of cationic side chains of the major antimicrobial region of human cathelicidin LL-37. Antimicrob. Agents Chemother. 56, 845-856. 

Menousek, J., Mishra, B., Hanke, M.L., Heim, C.E., Kielian, T., Wang, G. 2012. Database screening and in vivo efficacy of antimicrobial peptides against methicillin-resistant Staphylococcus aureus USA300. Int. J. Antimicrob. Agents 39, 402-406.

Wang, G., Li, X & Zasloff, M. 2010. A database view of naturally occurring antimicrobial peptides: nomenclature, classification and amino acid sequence analysis. In Wang, G. (ed.) "Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies". CABI, Oxfordshire, UK, pp. 1-21.

Wu, W.K.K., Wang, G., Coffelt, S.B., Betancourt, A.M., Lee, C.W., Yu, J., Sung, J.J.Y., & Cho, C.H. 2010. Emerging roles of the host defense peptide LL-37 in human cancer and its potential therapeutic applications. Int. J. Cancer 127(8):1741-1747. Equal contributions.

Wang, G. 2010. Database-aided prediction and design of novel antimicrobial peptides. In Wang, G. (ed.) "Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies". CABI, Oxfordshire, UK,  pp. 72-86.

Wang, G., Watson, K.M., Peterkofsky, A. & Buckheit, R.W. Jr. 2010. Identification of novel human immunodeficiency virus type 1 inhibitory peptides based on the antimicrobial peptide database. Antimicrob. Agents Chemotherapy. 54(3):1343-1346. PMCID: PMC2826022

Wang, G. 2010. Structural studies of antimicrobial peptides provide insight into their mechanisms of action. In Wang, G. (ed.) "Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies". CABI, Oxfordshire, UK, pp.141-168.

Wang, G. 2008. Structures of human host defense cathelicidin LL-37 and its smallest antimicrobial peptide KR-12 in lipid micelles. J. Biol. Chem. 283:32637-32643. PDB entry: 2K6O; BMRB entry: 15876.

Wang, G. 2007. Tool developments for structure-function studies of host defense peptides. Protein Pept. Lett. 14:57-69.

Li, Y., Li, X. & Wang, G. 2006. Cloning, expression, isotope labeling, and purification of human antimicrobial peptide LL-37 in Escherichia coli for NMR studies. Protein Exp. Purif. 47:498-505.

Li, X., Li, Y., Han, H-.Y., Miller, D.W. & Wang, G. 2006. Solution structures of human LL-37 fragments and NMR-based identification of a minimal membrane-targeting antimicrobial and anticancer region. J. Am. Chem. Soc. 128:5776-5785. PDB entries: 2FBS; 2FBU; 2FCG.

Wang, Z. & Wang, G. 2004. APD: the antimicrobial peptide database. Nucleic Acids Res. 32:D590-D592. Web site http://aps.unmc.edu/AP/main.html; PMCID: PMC308759.

Books
Wang, G. (ed.) 2010. Antimicrobial Peptides: Discovery, Design and Novel Therapeutic Strategies. CABI, Oxfordshire, UK. ISBN 978-1845-9365-70.

For a detailed list of publications, click here.

 

Guangshun (Gus) Wang, Ph.D.
Dr. Guangshun (Gus) Wang
Email Address
gwang@unmc.edu

Mailing Address
986495 Nebraska Medical Center
Omaha, NE 68198-6495

Office Address
WHM 4005B

Laboratory Address
WHM 4005

Phone Numbers
Office: 402-559-4176

Fax
402-559-4077

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