William W. West, M.D.

Department Affiliations
Associate Professor
Attending Staff: Cytology, Surgical Pathology, Consultation Cases

Interests
Pulmonary Pathology, Breast Pathology, Cytopathology, Ophthalmic Pathology, General Clinical Pathology and Clinical Chemistry

In anatomic pathology, my areas of focus include breast pathology, pulmonary pathology, ophthalmic pathology and cytopathology. Resident training, medical student education and diagnostic work in anatomic pathology and teaching account for much of my workday. My research interests involve the pathogenesis of the inflammatory response with lung exposure to organic dusts. Other projects include the possible hormonal etiology of breast carcinogenesis and the investigation of genetic markers that may account for different incidence rates of breast carcinoma in different populations. An additional area of research involves the assessment of telomerase levels in thyroid nodules using a novel in situ imaging method.

Education and Training
B.S., University of Nebraska Medical Center, 1974
M.D., University of Nebraska Medical Center, 1977
Residency, Internal Medicine, University of Nebraska Medical Center, 1977-1978
Residency, Pathology, University of Nebraska Medical Center, 1978-1982
Fellow, Pulmonary Pathology, University of British Columbia, Vancouver, British Columbia, Canada, 1982-1983
Board Certification, American Board of Pathology, Anatomic and Clinical Pathology, 1982
Board Certification in Cytopathology, American Board of Pathology, 1997.

Teaching Activities
Sophomore Medical Students: Pulmonary pathology, pathology of the upper respiratory tract, breast pathology, pathology of the eye.
Small group teaching - discussion groups and laboratories, anatomic and clinical pathology.
Cytotechnology Students: Cytology of the respiratory tract, breast, CSF; accreditation and regulations in cytology.
Pathology resident training in anatomic and clinical pathology.

National Activities
College of American Pathologists, Chemistry Resource Committee, 1992-1998, 2006-present.
College of American Pathologists, Member, Development Committee, 2005-present.
College of American Pathologists, Laboratory Accreditation Program, Deputy Regional Commissioner North Central Region, 1996-2003.
State Commissioner - Nebraska, North Dakota, South Dakota, 1995-2003.
Inspector, College of American Pathologists, Laboratory Accreditation Program, 1983-present.

Notable Publications
Poole JA, Wyatt TA, Oldenburg PJ, Elliot M, West WW, Sisson JH, VonEssen SG, Romberger DJ. Intranasal Organic Dust Exposure-Induced Airway Adaptation Response Marked by Persistent Lung Inflammation and Pathology in Mice. American Journal of Physiology-Lung Cellular and Molecular Immunology, 2009. 296(6): L1085-1095.

Rawlinson NJ, West WW, Nelson M, Bridge JA. Aggressive Angiomyxoma with t(12;21)(q15;q21.1) and HMGA2 Rearrangement: Report of a Case and Review of the Literature. Cancer Genetics and Cytogenetics. 181(2): 119-24, Mar 2008.

Streblow RC, Dafferner AJ, Nelson M, Fletcher M, West WW, Stevens RK, Gatalica Z, Novak D and Bridge JA. Imbalances of chromosomes 4, 9, and 12 are recurrent in the thecoma-fibroma group of ovarian stromal tumors. Cancer Genetics and Cytogenetics. 178(2): 135-140, October 2007.

Yi CH, Smith DJ, West WW, Hollingsworth MA. Loss of Fibulin-2 expression is associated with breast cancer progression. Am J Pathol, 170(5): 1535-1545, 2007.

Oh KB, Stanton MJ, West WW, Todd GL, Cardiff RD, Wagner K. Tsg 101 is upregulated in a subset of invasive human breast cancers and its targeted overexpression in transgenic mice reveals weak oncogenic properties for mammary cancer initiation. Oncogene, 26(40): 5950-9, Aug 2007.

Elliott MK, Sisson JH, West WW, Wyatt TA. Differential in Vivo Effects of Whole Cigarette Smoke Exposure Versus Cigarette Smoke Extract on Mouse Ciliated Tracheal Epithelium. Experimental Lung Research, 32: 99-118, 2006.

Madariaga MG, Kohl S, Starlin R, Smith PW, West WW. Visceral Leishmaniasis in an HIV infected patient. Infect Dis in Clin Pract, 14 (2):119-122, 2006.

Rao PS, Govindarajan R, Mallya KB, West W, Rao US. Characterization of a new antibody raised against the NH2 - terminus of P-glycoprotein. Clinical Cancer Research, 11 (16): 5833 – 5839, 2005.

Singh S, Chakravarti D, Edney J, Hollins R, Johnson P, West WW, Higginbotham S, Cavalieri E, Rogan E. Relative imbalance in the expression of estrogen-metabolizing enzymes in the breast tissue of women with breast carcinoma. Oncol Rep, Oct; 14(1):1091-6, 2005.

Rogan EG, Badawi AF, Devanesan PD, Meza JL, Edney JA, West WW, Higginbotham SM, Cavalieri EL. Relative imbalances in estrogen metabolism and conjugation in breast tissue of women with carcinoma: Potential biomarkers of susceptibility to cancer. Carcinogenesis, Apr;(4): 697-702, 2003.

For a detailed list of publications, click here.

William W. West, M.D.
William W. West, M.D.
Email Address
wwest@unmc.edu

Mailing Address
983135 Nebraska Medical Center
Omaha, Ne 68198-3135

Office Location
MSB 3562

Phone Numbers
Office: 402-559-5567

Fax
402-559-6018

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