Molecular regulation of B lineage cell development, Molecular regulation of V(D)J recombination and antibody repertoire formation, Abnormal B cell functions in autoimmune diseases, such as SLE and RA, B cell anti-HIV response, Pathogenesis of B cell malignancies
The research work in Dr. Zhang's laboratory focuses on understanding the molecular regulation of B lineage cell development. B lineage cells are the major players in our immune system to make antibodies against infection agents. Using the new knowledge obtained from basic research works to investigate the pathogenesis of different immunological diseases is Dr. Zhang's long term research goal and daily practice.
Education and Training
B.S., Nankai University, Tianjin, P. R. China, (Molecular Biology), 1989
M.S., Nankai University, Tianjin, P. R. China, (Molecular Biology), 1992
Ph.D., University of Alabama-Birmingham (Cell Biology), 1997
Post-doctoral training, University of Alabama at Birmingham (Immunology) 1997-2003
Graduate students and postdoctoral research fellows
Member, The American Association of Immunologists (1997-)
Member, New York Academy of Sciences (2005-)
Ad hoc reviewer for the Journal of Immunology (2004-)
Ad hoc reviewer for the Journal of Experimental Medicine (2004-)
Graduate Committee Member, UAB Department of Microbiology (2004-)
Qualify Examination Committee, UAB Department of Microbiology (2004-)
Managing Editor, Frontiers in Bioscience (2006-)
Editorial Board of Clinical Medicine: Arthritis and Musculoskeletal Disorders (2007-)
Ad hoc reviewer for Blood (2008-)
Ad hoc reviewer, Study section for Lupus Research Institute grant (2008-)
Zhang Z, VH replacement in mice and humans. Trends Immunol. 28: 132-137, 2007
Zhang Z*, Espinoza CR, Yu Z, Stephan R, He T, Williams GS., Burrows PD, Hagman J, Feeney AJ, and Cooper MD, Transcription factor Pax5 (BSAP) transactivates the RAG-mediated VH-to-DJH rearrangement of immunoglobulin genes. Nature Immunology, 7:616-624, 2006, (*Zhang, First and Co-corresponding author).
Liu Y, Fan R, Zhou S, Yu Z, Zhang Z, Potential Contribution of VH Gene Replacement in Immunity and Disease, Annals N.Y. Acad. Sci, 1062:1-7, 2005
Zhang Z, Burrows PD, Cooper MD. The molecular basis and biological significance of VH replacement. Immunol Rev. 2004;197:231-42.
Zhang Z, Zemlin M, Wang YH, Munfus D, Huye LE, Findley HW, Bridges SL, Roth DB, Burrows PD, Cooper MD. Contribution of Vh gene replacement to the primary B cell repertoire. Immunity. 2003, 19(1):21-31.
Zhang Z, Wang YH, Zemlin M, Findley HW, Bridges SL, Burrows PD, Cooper MD. Molecular mechanism of serial VH gene replacement. Ann N Y Acad Sci. 2003, 987:270-3.
Wang YH, Zhang Z, Burrows PD, Kubagawa H, Bridges SL Jr, Findley HW, Cooper MD. V(D)J recombinatorial repertoire diversification during intraclonal pro-B to B-cell differentiation. Blood. 2003, 101(3):1030-7.
Burrows PD, Stephan RP, Wang YH, Lassoued K, Zhang Z, Cooper MD. The transient expression of pre-B cell receptors governs B cell development. Semin Immunol. 2002, 14(5):343-9.
Gongora R, Stephan RP, Zhang Z, Cooper MD. An essential role for Daxx in the inhibition of B lymphopoiesis by type I interferons. Immunity. 2001, 14(6):727-37.
Zhang Z, Wu X, Limbaugh BH, Bridges SL Jr. Expression of recombination-activating genes and terminal deoxynucleotidyl transferase and secondary rearrangement of immunoglobulin kappa light chains in rheumatoid arthritis synovial tissue. Arthritis Rheum. 2001, 44(10):2275-84.
For a detailed list of publications, click here.
987660 Nebraska Medical Center
Omaha, NE 68198-7660