Community Acquired Bacteremic Syndromes in Young Nigerian Children

 

The principal goal of CABSYNC is to define the etiologic agents of community acquired bacteremic syndromes in a malaria endemic setting and to provide information on host immune responses that could be useful in developing primary and secondary preventative measures.

 

Objectives of project are to:

  1) Define and characterize the etiologic agents of community acquired bacteremic syndromes in young Nigerian Children.

  2) Determine the role of respiratory viruses in promoting the severity of bacteremic and radiologic pneumonia.

  3) Determine acute host inflammatory response profiles in bacteremic syndromes associated with respiratory distress.  

 

Community Acquired Pneumonia and Invasive Bacterial Diseases in Young Nigerian Children

 

The primary goal of CAPIBD is to create a platform for the generation of local data on the causes and burden of community acquired pneumonia, opportunistic and bacteremic syndromes (bacteremia, sepsis and meningitis) in order to promote their prevention by increasing the use of existing vaccines, by stimulating development of new vaccines and by providing a platform for subsequent monitoring of the impact of these vaccines.

 

Objectives of the project are to:

  1) Establish two field and laboratory sites to determine pathogen specific burden of bacteremic syndromes in children.

  2) Determine incidence rates of childhood bacteremic syndromes.

  3) Determine the role of reparatory viruses in sever child pneumonia

  4) Determine the role of co-morbid conditions (HIV, SCD and malaria) in bacteremic syndromes. 

 

Global Genomic and Proteomic Profiling of African Children with Typhoid Fever

 

The overall goal of this project is to develop innovative molecular diagnostic assays for rapid and inexpensive detection of typhoid fever as well as to better understand its molecular mechanisms and host response to facilitate the development of next-generation typhoid fever vaccines.

 

Objectives of the project are to:

  1) Define typhoid fever-specific host response classifier genes using gene expression microarrays.

  2) Discover specific serum anti-typhoid fever proteins using newly established S. Typhi proteome microarrays.

  3) Develop prototype serologic assay for acute typhoid.

  4) Validate classifier genes and filed-test prototype ELISAs using new, independent cohorts. 

 

Training & Education

 

In line with IFAIN’s objective of training healthcare professionals and students it continuously seeks new educational opportunities for its employees and professionals at collaborating institutions. By growing local human capital IFAIN seeks to strengthen capacity within Nigerian and bolster the future healthcare providers.  

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