UNMC | NanoART Manufacture, Delivery & Pharmacokinetics-Publications

2012
Bathena SP, Huang J, Nunn ME, Miyamoto T, Parrish LC, Lang MS, McVaney TP, Toews ML, Cerutis DR, Alnouti Y. Quantitative determination of lysophosphatidic acids in human saliva and gingival crevicular fluids by LC-MS/MS. J Pharm Biomed Anal. 2011 Sep 10;56(2):402-7. Epub 2011 Jun 6. PMCID: PMC3134166

*Balkundi, S., Nowacek, A.S., Veerubhotla, R.S., Chen, H., Martinez-Skinner, A., Roy, U., Mosley, R.L., Kanmogne, G., Liu, X., Kabanov, A.V., Bronich, T., McMillan, J., Gendelman, H.E. Comparative Manufacture and Cell-based Delivery of Antiretroviral Nanoformulations. Intl J Nanomedicine, 2011; 6 1-12. PMCID: PMC3260033

Batrakova, E.V., Gendelman, H.E., Kabanov, A.V. Cell-mediated drug delivery. Expert Opin Drug Deliv. 2011; Apr;8(4):415-33. Epub 2011 Feb 24. PMCID: PMC3062753

*Dash, P.K., Gorantla, S., Gendelman, H.E., Knibbe, J., Casale, G.P., Makarov, E., Epstein, A.A., Gelbard, H.A., Boska, M.D., Poluektova, L.Y. Loss of Neuronal Integrity During Progressive HIV-1 Infection of Humanized Mice. J. Neuroscience. 2011; Mar 2;31(9):3148-57. PMCID: PMC3059783

Gendelman, H.E. and Appel, S.H. Neuroprotective activities of regulatory T cells. Trends in Molecular Medicine, 2011; Dec; 17(12):687-8. PMC Journal – in Process

*Gorantla, S., Gendelman, H.E., Poluektova L. Can Humanized Mice Reflect the Complex Pathobiology of HIV-Associated Neurocognitive Disorders? J Neuroimmune Pharmacol, 2012 7(2):352-62, PMC Journal – In Process

*Gorantla S, Poluektova LY, Gendelman HE. Rodent models for HIV-associated neurocognitive disorders. Trends in Neurosciences, 2012, 35 (3): 197-208. PMCID: PMC3294256

Grant, K.M., LeVan, T.D., Wells, S.M., Li, M., Stoltenberg, S.F., Carlo, G., Gendelman, H.E., and Bevins, R.A. Methamphetamine-Associated Psychosis. J. Neuroimmune Pharm. 2012 7(1):113-39. PMCID: PMC3280383

Handler, M.Z., Miriovsky, B., Gendelman, H.E., Sandkovsky, U. Fusobacterium necrophorum causing infective endocarditis and liver and splenic abscesses. Rev Inst Med Trop São Paulo. 2011; June;53(3):169-72. Review.

Haney, M.J., Suresh, P., Zhao, Y., Kanmogne, G.D., Kadiu, I., Klyachoko, N.L., Mosley, R.L. Kabanov, A., Gendelman, H.E., and Batrakova, E.V. Blood-borne macrophage neural cell interactions facilitates trafficking of nanozymes in cell-based drug delivery. In press, Nanomedicine (Lond), 2012, 7(6):815-33. PMCID: PMC3384770

Haney, M.J., Zhao, Y., Li, S., Higginbotham, S.M., Booth, S.L., Han, Y.Y., Vetro, J.A., Mosley, R.L., Kabanov, A.V., Gendelman, H.E., Batrokova. E. Cell-mediated transfer of catalase nanoparticles from macrophages to brain endothelial, glial and neuronal cells: Implications for nanomedicine drug delivery to the central nervous system, Nanomedicine (London). 2011; Sep;6(7):1215-30. Epub ahead of print Mar 31 2011]. PMCID: PMC3166447

*Huang, J., Gautam, N., Bathena, S.P., Roy, U., McMillan, J., Gendelman, H.E., Alnouti, Y. UPLC-MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues. J Chromatogr B Analyt Technol Biomed Life Sci. 2011; Aug 1;879(23):2332-8. PMCID: PMC3144699

Hutter-Saunders, J.A.L., Gendelman, H.E., Mosley, R.L. Murine motor and behavior dysfunctions follow acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxication. J. Neuroimmune Pharm. 2012 7(1): 279-88. PMCID: PMC3392900

Hutter-Saunders, J.A.L., Kosloski, L.M., McMillan, J.E., Yotam, N., Rinat, T., Mosley, R.L., Gendelman, H.E. BL-1023 improves behavior and neuronal survival in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineintoxicated mice. Neuroscience. 2011; Apr 28;180:293-304. Epub 2011 Feb 12. PMCID: PMC3070792

Hutter-Saunders, J.A.L., Mosley, R.L., Gendelman, H.E. Pathways towards an Effective Immunotherapy for Parkinson’s disease. Expert Rev Neurother. 2011; Dec; 11(12):1703-15. PMCID: PMC3263336

Hutter, J.A.L., Poluektova, L., Dhawan, S., Gendelman, H.E. Adaptive Immunity. In: The Neurology of AIDS, Third Edition. Eds: H.E. Gendelman, I.P. Everall, H.S. Fox, H.A. Gelbard, I. Grant, S.A. Lipton, S. Swindells. Oxford University Press, New York, 2011; pp 131-145 (Publication not peer reviewed)

*Kadiu, I. and Gendelman, H.E. Macrophage bridging conduit trafficking of HIV-1 through the endoplasmic reticulum and Golgi network. J Proteome Res. 2011; Jul 1;10(7):3225-38 PMCID: PMC3128463

*Kadiu, I. and Gendelman, H.E. Human immunodeficiency virus type 1 endocytic trafficking through macrophage bridging conduits facilitates spread of infection. J. Neuroimmune Pharmacol. 2011; Dec;6(4):658-75. PMCID: PMC3232570

*Kadiu, I., Nowacek, A., McMillan, J., Gendelman, H.E. Macrophage endocytic trafficking of antiretroviral nanoparticles. Nanomedicine (Lond). 2011; Aug;6(6):975-94 PMCID: PMC3184214

*Kanmogne GD, Singh S, Roy U, Liu X, McMillan J, Gorantla S, Balkundi S, Smith N, Alnouti Y, Gautam N, Zhou Y, Poluektova L, Kabanov A, Bronich T, and Gendelman HE. Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell targeted nanoformulated antiretroviral drugs to human brain endothelial cells. Internt’l J. Nanomedicine. 2012 7:2373-88 PMCID: PMC3357981

*Kraft-Terry, S., Engebretsen, I.L., Bastola, D.K., Fox, H.S., Ciborowski, P., Gendelman, H.E. Pulsed Stable Isotope Labeling of Amino Acids in Cell Culture Uncovers the Dynamic Interactions between HIV-1 and the Monocyte-Derived Macrophage. J Proteome Res. 2011; 10(6):2852-2862. PMC3108467

*Kraft-Terry, S. and Gendelman, H.E. Proteomic Biosignatures for Monocyte-Macrophage Differentiation. Cellular Immunology, 2011; 271(2):239-55 PMCID: PMC3195886

*Kraft-Terry, S. Gerena, Y., Wojna, V., Plaud-Valentin, M., Rodriguez, Y., Ciborowski, P., Mayo, R., Skolasky, R., Gendelman, H.E., Melendez, L.M. Proteomic analyses of monocytes obtained from Hispanic women with HIV-associated dementia show depressed antioxidants. Proteomics Clin Appl. 4(8-9):76-714 PMCID: PMC3098323

Lan, X., Kiyota, T. Hanamsagar, R., Huang, Y., Andrews, S., Peng, H., Zheng, J., Swindells, S. Carlson, G. Ikezu, T. The effect of HIV protease inhibitors on amyloid-β peptide degradation and synthesis in human cells and Alzheimer’s disease animal model. J Neuroimmune Pharmacol. 2012, 7(2):412:23 PMCID: PMC3223330

Liu, Y., Sajja, B., Uberti, M., Gendelman, H.E., Kielian, T.L., Boska, M. Landmark Optimization Using Local Curvature for Point-Based Nonlinear Rodent Brain Image Registration. International Journal of Biomedical Imaging, 2012;2012:635207 Epub 2011 Sep 26. vol. 2012, 8 pgs. PMCID: PMC3180176

*Martinez-Skinner, A., Nowacek, A., McMillan, J., Gendelman, H.E. Mononuclear phagocytes as vehicles for viral dissemination, cellular viral reservoirs, and immune effectors in the neuropathogenesis of HIV-1 infection. In: The Neurology of AIDS, Third Edition. Eds: H.E. Gendelman, I.P. Everall, H.S. Fox, H.A. Gelbard, I. Grant, S.A. Lipton, S. Swindells. Oxford University Press, New York, 2011; pp 257-274 (Publication not peer reviewed)

*McMillan, J., Batrakova, E., Gendelman, H.E. Cell Delivery of Therapeutic Nanoparticles. Prog Mol Biol Transi Sci. 2011;104:563-601. PMC Journal – in Process

*Nowacek, A., Batrakova, E.V., McMillan, J., Gang, N., Gendelman, H.E. Nanomedicine and neurodegenerative disorders. In: Nanomedicine in Health and Disease. Oxford University Press: New York, in press 2011. (Publication was not peer reviewed)

*Nowacek, A., Zhang, G., McMillan, J., Kiyota, T., Batrakova, E. and Gendelman, H.E. Nanomedicine and Neurodegenerative Disorders. In: Nanomedicine in Health and Disease, eds. Hunter and Preedy, Science Publishers, an imprint of Edenridge Ltd., Enfield, NH, pp 377-397, 2011. (Publication not peer reviewed)

*Roy, U, Balkundi S., McMillan, J., Gendelman, H.E. Nanomedicine to improve central nervous system drug delivery in neuroAIDS. In: The Neurology of AIDS, Third Edition. Eds: H.E. Gendelman, I.P. Everall, H.S. Fox, H.A. Gelbard, I. Grant, S.A. Lipton, S. Swindells. Oxford University Press, New York, 2011; pp 987998 (Publication not peer reviewed)

*Roy, U., McMillan, J., Alnouti, Y., Gautum, N., Smith, N., Balkundi, S., Dash, P., Gorantla, S., Martinez-Skinner, A., Meza, J., Kanmogne, G., Swindells, S., Cohen, S.M., Mosley, R.L., Poluektova, L., Gendelman, H.E. Pharmacodynamic and Antiretroviral Activities of Combination Nanoformulated Antiretrovirals in HIV-1-Infected Human PBL-Reconstituted Mice. J. Infect. Dis., 2012. In press. PMC Journal – In Process

Wiederin, J.L., Yu, F., Donahoe, R.M., Fox, H.S., Ciborowski, P., Gendelman, H.E. Changes in the plasma proteome follows chronic opiate administration in simian immunodeficiency virus infected rhesus macaques. Drug Alcohol Depend. 2011 Aug 5 [Epub ahead of print]. PMCID: PMC3245805

Yannam GR, Gutti T, Poluektova LY. IL-23 in Infections, Inflammation, Autoimmunity and Cancer: Possible Role in HIV-1 and AIDS. J Neuroimmune Pharmacol. 2011 Sep 24. [7(1):95-112 PMCID: PMC3288567

Zhao, Y., Haney, M.J., Klyachko, N.L., Li, S., Booth, S.L., Higginbotham, S.M., Jones, J., Zimmerman, M.C., Mosley, R.L., Kabanov, A.V., Gendelman, H.E., Batrakova, E.L. Polyelectrolyte complex optimization for macrophage delivery of redox enzyme nanoparticles. Nanomedicine (London). 2011 Jan;6(1):25-42. PMC Journal – in Process

Zhao, Y., Haney, M.J., Mahajan, V., Reiner, B.C., Dunaevsky, A., Mosley, R.L., Kabanov, A.V., Gendelman, H.E., Batrakova, E.V. Active Targeted Macrophage-mediated Delivery of Catalase to Affected Brain Regions in Models of Parkinson's Disease. J Nanomed Nanotechnol. 2011 Sep 10;S4. pii: 003. PMCID: PMC3267477

Submitted/In Revision

*Dash, P., Gorantla, S., Roy, U., Balkundi, S., Mosley, R.L., McMillan, J., Gelbard, H.A., Gendelman, H.E., Poluektova, L. Safety and Efficacy of Injectable Long-Acting Antiretroviral Nanoformulations in HIV-1 Infected Humanized Mice. Nature Medicine, 2012. Submitted

*Kadiu, I. and H.E. Gendelman. Characterization of the macrophage exosome. J. Immunol. Revised. 2012.

Project 2

Inventions and Patents:

Patent Portfolio

Docket No.	Invention No.	Filing Date	Application No. / Patent No.	Status	Inventors	Title
11076P	11076	05/26/11	61/490,429	Pre-conversion	Gendelman, Kabanov, Liu	Compositions and Methods for Targeted Drug Delivery
12008P	12008	08/23/11	61/526,556	Pre-conversion	Gendelman, Kadiu	Exosome Antiretroviral Drug Therapies
11037P1	11037/ 11076	08/24/11	61/526,976	Converted to PCT	Gendelman, Kabanov, Liu	Compositions and Methods for the Delivery of Therapeutics
11037PCT	11037/ 11076	11/2/11	PCT/US11/58929	Pre-nationalization	Gendelman, Kabanov, Liu	Compositions and Methods for the Delivery of Therapeutics

Invention Portfolio:

Invention No.	Status	Inventors	Title
11076	Market/Protect	Gendelman, Kabanov, Liu	Targeting Folate NanoARTs and Their Use Thereof
12008	Market/Protect	Gendelman	Exosomes as Antiretroviral Drug Delivery Vehicles

2011

Balkundi, S., Nowacek, A.S., Roy, Upal, Martinez-Skinner, A., McMillan, J. Gendelman, H.E. Methods Development for Blood Borne Macrophage Carriage of Nanoformulated Antiretroviral Drugs. Journal of Visualized Experiments (JoVE). Video Article #2460. PMC Journal – In Process

Boska, M., Liu, Y., Uberti, M., Saija, B.R., Balkundi, S., McMillan, J., Gendelman, H.E. Registered Bioimaging of Nanomaterials for Diagnostic and Therapeutic Monitoring. Journal of Visualized Experiments (JoVE). Video Article #2459. PMC Journal – In Process

Bressani, R.F., Nowacek, A.S., Singh, S., Balkundi, S., Rabinow, B., McMillan, J., Gendelman, H.E., Kanmogne, G.D. Pharmacotoxicology of monocyte-macrophage nanoformulated antiretroviral drug uptake and carriage. In press, Nanotoxicology, 2011. PMC Journal – In Process

Dash, P.K., Gorantla, S., Gendelman, H.E., Knibbe, J., Casale, G.P., Makarov, E., Epstein, A.A., Gelbard, H.A., Boska, M.D., Poluektova, L.Y. Loss of Neuronal Integrity During Progressive HIV-1 Infection of Humanized Mice. In press, J. Neuroscience. 2011. PMC Journal – in Process

Fox, Howard S. HIV-1 and Methamphetamine. In: The Neurology of AIDS 3^rdEdition. Eds. Gendelman, H.E., Everall, I., Fox, H., Grant, I., Lipton, S., Swindells, S. In Press, Oxford University Press, Oxford 2011.

Gorantla, S., Makarov, E., Finke-Dwyer, J., Castanedo, A., Holguin, A., Gebhart, C.L., Gendelman, H.E., Poluektova, L. Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesis. Am J Pathol. 2010 Dec;177(6):2938-49. PMCID: PMC2993281

Haney, M.J., Zhao, Y., Li, S., Higginbotham, S.M., Booth, S.L., Han, Y.Y., Vetro, J.A., Mosley, R.L., Kabanov, A.V., Gendelman, H.E., Batrokova. E. Cell-mediated transfer of catalase nanoparticles from macrophages to brain endothelial, glial and neuronal cells: Implications for nanomedicine drug delivery to the central nervous system. In press. Nanomedicine (London) 2011. PMC Journal –in Process

Hutter-Saunder, J.A.L., Kosloski, L.M., McMillan, J.E., Yotam, N., Rinat, T., Mosley, R.L., Gendelman, H.E. BL-1023 improves behavior and neuronal survival in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-intoxicated mice. In press. Neuroscience PMC Journal – in Process

Hutter, J.A.L., Poluektova, L.Y., Devadas, L, Lal, R.B., Dhawan, S., Gendelman, H.E. Adaptive immunity in HIV-1 and neurodegenerative diseases. In: The Neurology of AIDS 3^rdEdition. Eds. Gendelman, H.E., Everall, I., Fox, H., Grant, I., Lipton, S., Swindells, S. In Press, Oxford University Press, Oxford 2011.

Kadiu, I., Nowacek, A., McMillan J., Gendelman, H.E. Macrophage endocytic trafficking of antiretroviral nanoparticles. in press Nanomedicine (London), 2011. PMC Journal – in Process

Martinez-Skinner, A., Nowacek, A., McMillan, J., Gendelman, H.E. Mononuclear phagocytes as vehicles for viral dissemination, cellular viral reservoirs, and immune effectors in the neuropathogenesis of HIV-1 infection. In: The Neurology of AIDS 3^rdEdition. Eds. Gendelman, H.E., Everall, I., Fox, H., Grant, I., Lipton, S., Swindells, S. In Press, Oxford University Press, Oxford 2011.

Nowacek, A., Batrakova, E.V., McMillan, J., Gang, N., Gendelman, H.E. Nanomedicine and neurodegenerative disorders. In press In: Nanomedicine in Health and Disease. Oxford University Press: New York, 2011.

Nowacek, A.S., Balkundi, S., McMillan, J., Roy, U., Martinez-Skinner, A., Mosley, R.L., Kanmogne, G., Kabanov, A.V., Bronich, T., Gendelman, H.E. Analyses of nanoformulated antiretroviral drug charge, size, shape and content for uptake, drug release and antiviral activities in human monocyte-derived macrophages. J. Control Release. 2010 Nov 23. [Epub ahead of print]. PMC Journal – In Process

Roy, U., Balkundi S., McMillan, J., Gendelman, H.E. Nanomedicine to improve central nervous system drug delivery in neuroAIDS. In: The Neurology of AIDS 3^rdEdition. Eds. Gendelman, H.E., Everall, I., Fox, H., Grant, I., Lipton, S., Swindells, S. In Press, Oxford University Press, Oxford 2011.

Wiederin, J.L., Donahoe, R.M., Anderson, J.R., Yu, F., Fox, H.S., Gendelman, H.E., Ciborowski, P.S. Plasma proteomic analysis of simian immunodeficiency virus infection of rhesus macaques. J Proteome Res. 2010 Sep 3;9(9):4721-31. PMC Journal – In Process

Zhao, Y., Haney, M.J., Klyachko, N.L., Li, S., Booth, S.L., Higginbotham, S.M., Jones, J., Zimmerman, M.C., Mosley, R.L., Kabanov, A.V., Gendelman, H.E., Batrakova, E.L. Polyelectrolyte complex optimization for macrophage delivery of redox enzyme nanoparticles. Nanomedicine (London). 6(1):25-42, 2011. PMCID: PMC3037278