Prabagaran Narayanasamy PhD
Durham Research Center, 3044
Phone: 402-559-8916 (L), 402-559-3482 (O)
Keywords: tuberculosis, HIV, drug discovery, drug delivery, antibiotics, medicinal chemistry, glyoxalase pathway, quorum sensing, MEP pathway, menaquinone inhibitor, protease inhibitor, non-nucleoside reverse transcriptase inhibitor, exosomes, metabolites, neurodegenerative disorders
My main focus is on development, delivering and discovering drug for anti-bacterial medicine and antiretroviral therapy. Conventional drugs and new inhibitors are used in nanoformulation to generate active nanomedicine. Pharmacokinetic and pharmacodynamics of new nanomedicine are carried out, in particular, in vitro studies like drug uptake in macrophages, drug release by macrophages, its cell toxicity, cytokine and chemokine generation or modification are evaluated. Receptor targeted drug delivery will be also shown interest in future. In vivo studies will be focused to study the function of drugs, efficacy of formulation, and toxicity. For antibacterial drug discovery glyoxalase, quorum sensing, MEP and menaquinone pathway are utilized. Additionally, development of exosomes as drug delivering agent is initiated and will be explored. Last but not the least, metabolites are evaluated in the infected brain for characterizing neurodegenerative disorders.
Long Term Goals: Drug design, discovery, development and delivery for bacterial diseases and antiretroviral infection. We are also interested in drug development for HIV-TB coinfection and exploring properties of brain metabolites for neurodegenerative disorders.
Edagwa, B., Wang, Y., Narayanasamy, P. (2013), Synthesis of azide derivative and discovery of glyoxalase pathway inhibitor against pathogenic bacteria, Bioorganic & Medicinal Chemistry Letters. http://dx.doi.org/10.1016/j.bmcl.2013.09.011. PMID: 24076169
A. Epstein, P. Narayanasamy, P. Dash, R. High, S. Bathena, S. Gorantla, L. Poluektova, Y. Alnouti, H. Gendelman, M. Boska. (2013) Brain tissue metabolomics predict histopathology in rodent models of human immunodeficiency virus infection of the nervous system. J Neuroimmunol. (in press). DOI 10.1007/s11481-013-9461-9. PMID: 23702663
I. Kadiu, P. Narayanasamy, P. Das, W. Zhang, H. Gendelman. (2012) Biochemical and biologic characterization of exosomes and microvesicles as facilitators of HIV-1 infection in macrophages. J. Immunology. (in press)
P. Narayanasamy*,H. Eoh, P. J. Brennan, and D. C. Crick. (2010) Synthesis of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate and kinetic studies of Mycobacterium Tuberculosis IspF. Chemistry and Biology, 17, 117-122. PMCID: PMC2837070
R.W. Honaker, R.K. Dhiman, P. Narayanasamy, D.C. Crick, M.I. Voskuil.(2010) DosS responds to a reduced electron transport system to induce the Mycobacterium tuberculosis DosR regulon.. J Bacteriol. 192, 6447-6455. PMCID: PMC3008535
P. Narayanasamy, H. Eoh, A. C. Brown, T. Parish, P. J. Brennan, and D. C. Crick. (2009). Expression and characterization of soluble 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase from bacterial pathogens. Chemistry and Biology, 16, 1230-1239. PMID: 20064433
R. K. Dhiman, S. Mahapatra, R. A. Slayden, M. E. Boyne, A. Lenaerts, J. C. Hinshaw, S. K. Angala, D. Chatterjee, K. Biswas, P. Narayanasamy, M. Kurosu, D. C. Crick. (2009). Menaquinone synthesis is critical for maintaining mycobacterial viability during exponential growth and recovery from non-replicating persistence. Mol. Microbiol. 72, 85-97. PMID: 19220750
P. Narayanasamy,* H. Eoh, and D. C. Crick. (2008). Chemoenzymatic synthesis of 4-Diphosphocytidyl-2-C-methyl-D-erythritol: A substrate for IspE. Tetrahedron Letters, 4461-4463. PMCID: PMC2832204
P. Narayanasamy* and D. C. Crick. (2008). Enantiomeric Synthesis of 2-C-Methyl-D-erythritol 2, 4- cyclodiphosphate. Heterocycles, 76, 243. PMCID: PMC2658599
M. Kurosu, P. Narayanasamy, K. Biswas, R. Dhiman, and D. C. Crick. (2007). Discovery of 1, 4-dihydroxy-2-naphthoate prenyl transferase inhibitors: New drug leads for Multidrug-Resistant gram-positive pathogens. Journal of Medicinal Chemistry, 3973-3975. PMCID: PMC2591091
M. Kurosu, S. Mahapatra, P. Narayanasamy, and D. C. Crick. (2007). Chemoenzymatic synthesis of Park’s nucleotide: toward the development of high-throughput screening for MraY inhibitors. Tetrahedron Letters, 48, 799-803.
K. Fraunhoffer, N. Prabagaran, L. Sirois, and M. C. White. (2006). Macrolactonization via hydrocarbon oxidation. Journal of American Chemical Society, 128, 9032-9033. PMCID: PMC2720785
M. S. Chen, N. Prabagaran, N. Labenz, and M. C. White. (2005). Serial ligand catalysis: A highly selective allylic C-H oxidation. Journal of American Chemical Society, 127, 6970-6971. PMID: 15884938
M. P. Sibi, Z. Ma, K. Itoh, N. Prabagaran, and C. Jasperse. (2005). Enantioselective cycloadditions with a,b-disubstituted acrylimides. Organic Letters, 7, 2349-2352. PMID: 15932195
M. P. Sibi and N. Prabagaran. (2004). Chiral relay in enantioselective conjugate radical additions using pyrazolidine templates. How does metal geometry impact selectivity? Synthetic Letters, 13, 2421-2424.
M. P. Sibi, N. Prabagaran, S. Ghorpade, and C. Jasperse. (2003). Enantioselective synthesis of a,b-disubstituted b-Amino acids. Journal of American Chemical Society, 125, 11796-11797. PMID: 14505383
N. Prabagaran and G. Sundararajan. (2002). Asymmetric Michael addition reactions using La-Na heterobimetallic chiral catalyst. Tetrahedron: Asymmetry, 13, 1053-1058.
G. Sundararajan and N. Prabagaran. (2001). A new polymer-anchored chiral catalyst for asymmetric Michael addition reactions. Organic Letters, 3, 389-392. PMID: 11428021
G. Sundararajan, N. Prabagaran, and B. Varghese. (2001). First asymmetric synthesis of quinoline derivatives by Inverse Electron Demand (IED) Diels-Alder reaction using chiral Ti(IV) complex. Organic Letters, 3, 1973-1976. PMID: 11418027