Visit Dr. Bidasee's lab
KESHORE BIDASEE, PhD
Durham Research Center 3047
985800 Nebraska Medical Center
Omaha, NE 68198-5800
Phone: 402- 559-9018
Keywords: Diabetes, heart, muscle contraction, calcium cycling proteins ryanodine receptors, Ca2+-ATPase, myosin heavy chain, echocardiography, calcium transients
Dr. Bidasee in his own words.
Research Interests :
Effect of diabetes on expression and function of calcium cycling proteins
Long range goals: To (i) better understanding molecular mechanisms by which the activity of ryanodine receptor calcium-release channels and sarcoplasmic reticulum calcium ATPase decreases during diabetes, and (ii) identify therapeutic strategies modalities to slow the progression of this "diabetic heart muscle disease."
Significance: This research is especially important because it could lead to improvements in the quality of life for diabetic patients and help control the escalating economic cost medical expenditure and loss productivity which was estimated at $132 billion in 2002.
- Shao CH, Wehrens XH, Wyatt TA, Parbhu S, Rozanski GJ, Patel KP, Bidasee KR. Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation. Shao CH, Wehrens XH, Wyatt TA, Parbhu S, Rozanski GJ, Patel KP, . Exercise training during diabetes attenuates cardiac ryanodine receptor dysregulation. J Appl Physiol (2009) 106(4):1280-1292
- Li S, Li X, Zheng H, Xie B, Bidasee KR, Rozanski GJ. Pro-oxidant effect of transforming growth factor- 1 mediates contractile dysfunction in rat ventricular myocytes. Cardiovasc Res (2008) 77(1):107-17
- Bidasee KR, Zheng H, Shao CH, Parbhu, S, Rozanski GJ, Patel KP. Exercise training initiated after the onset of diabetes preserves myocardial function: effects on express of beta-adrenoceptors. . J Applied Physiology (2008) 105(3):907-14
- Banerjee S, & Walseth, TF, Borgmann K, Bidasee KR, Kannan MS and Ghorpade A. CD38/Cyclic ADP Ribose Regulates Astrocyte Calcium Signaling: Implications for Neuroinflammation and HIV-1-Associated Dementia. J Neuroimmune Pharmacol. (2008) 3(3):154-64
- Zheng H, Bidasee KR, Mayhan WG, Patel KP. Lack of central nitric oxide triggers erectile dysfunction in diabetes. Am J Physiol Regul Integr Comp Physiol. (2007) 292(3):R1158-64
Work in our lab has been funded by the National Institutes of Health
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