Welcome to Dr. Keshore Bidasee's Laboratory
Dr. Kaushik P. Patel, University of Nebraska Medical Center
Dr. George Rozanski, University of Nebraska Medical Center
Dr. Gerhard Meissner, University of North Carolina, Chapel Hill,
Dr. Wayne Chen, University of Alberta, Canada
Dr. Henry R. Besch, Jr., Indiana University School of Medicine
Dr. U. Deniz Dincer, Ufuk Universitesi Tip Fakultesi, Ankara, Turkey
Effect of diabetes on expression and function of calcium cycling proteins
Long range goals:To (i) better understanding molecular mechanisms by which the activity of ryanodine receptor calcium-release channels and sarcoplasmic reticulum calcium ATPase decreases during diabetes, and (ii) identify therapeutic strategies modalities to slow the progression of this "diabetic heart muscle disease."
Significance: This research is especially important because it could lead to improvements in the quality of life for diabetic patients and help control the escalating economic cost medical expenditure and loss productivity which was estimated at $132 billion in 2002.
Role of Ryodine Receptors in Diabetic Cardiomyopathy
PI: Bidasee, K.
The goals of this project are to investigate the effects of diabetes on expression and function of cardiac ryanodine receptors and to determine if changes induced by diabetes can be attenuated with drug and exercise training.
Reactive Carbonyl Species and Neurological Disorders
Nebraska Redox Biology Center
- Generation and caring for streptozotocin-induced diabetic rats
- Video edge detection (myocyte contractility)
- Laser confocal microscopy (calcium transients)
- Receptor binding PCR and western blot analyses
- Site-directed mutagenesis
- Lipid bilayer
- Mass spectrometry (MALDI-TOF and Tandem)
- Chemical synthesis
- Left ventricular pressure measurements (in vivo)
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