Jean D. Deupree
Keywords: Adolescent, Depression, Adrenergic Receptors, Behavioral, Brain, Children, Neuropharmacology, Receptor Binding, Receptor Regulation
Neurotransmitters and hormones produced their effects by acting on receptors which in turn initiates a signaling cascade within the cell. I am particularly interested in the alpha-2 adrenergic receptors that are involved in some of the actions of epinephrine and norepinephrine. The alpha-2 adrenergic receptors belong to the G protein-coupled family of receptors and are involved in central and peripheral control of blood pressure, platelet function, behavior and sleep.
In collaboration with Dr. Bylund, I have been involved in determining the characteristics of the different alpha-2 adrenergic receptor subtypes and how the receptors are down regulated upon long term exposure to agonists. My current focus is to determine how adrenergic receptors are regulated in juvenile rats during chronic antidepressant treatment. This research will help us to better understand why not all antidepressants work in children and how to better treat depression in children. Another focus of my research has been to determine whether alpha-2 adrenergic receptors are involved in attention deficit hyperactivity disorder (ADHD). I have also developed a computer based methods for teaching pharmacology and receptor binding techniques.