Jean Deupree, PhD

Jean D. Deupree

Jean D. Deupree

Professor Emeritus
Ph.D., Biochemistry, 1970
Michigan State University
Phone: (402) 559-4565
FAX: (402) 559-7495
E-mail: jddeupre@unmc.edu

Keywords: Adolescent, Depression, Adrenergic Receptors, Behavioral, Brain, Children, Neuropharmacology, Receptor Binding, Receptor Regulation

Research Interest

Neurotransmitters and hormones produced their effects by acting on receptors which in turn initiates a signaling cascade within the cell. I am particularly interested in the alpha-2 adrenergic receptors that are involved in some of the actions of epinephrine and norepinephrine. The alpha-2 adrenergic receptors belong to the G protein-coupled family of receptors and are involved in central and peripheral control of blood pressure, platelet function, behavior and sleep.

In collaboration with Dr. Bylund, I have been involved in determining the characteristics of the different alpha-2 adrenergic receptor subtypes and how the receptors are down regulated upon long term exposure to agonists. My current focus is to determine how adrenergic receptors are regulated in juvenile rats during chronic antidepressant treatment. This research will help us to better understand why not all antidepressants work in children and how to better treat depression in children. Another focus of my research has been to determine whether alpha-2 adrenergic receptors are involved in attention deficit hyperactivity disorder (ADHD). I have also developed a computer based methods for teaching pharmacology and receptor binding techniques.



  •  Representative Publications

    1. Deupree, J.D., C.D Borgeson and D.B. Bylund, Down-regulation of the Alpha-2C Adrenergic Receptor: Involvement of a Serine/Threonine Motif in the Third Cytoplasmic Loop. BMC Pharmacology 2002, 2:9.
    2. Deupree, J.D. and Lurz, M. Tutorial on Receptor Binding Techniques.
    3. Deupree, J.D., Scofield, M.A.,, and Bylund, D.B. Analyses of adrenergic receptor sequences, In Adrenergic Receptor Protocol, ed by C. A. Machida, pp.53-72, Humana Press, 2000.
    4. Deupree, J.D., Hinton, K.A., Cerutis, D.R. and Bylund, D.B. Buffers differentially alter the binding of [3H]rauwolscine and [3H]RX821002 to the alpha2-adrenergic receptor subtypes. J. Pharmacol. exp. Ther. 278:1215-1227, 1996.
    5. Bucci, K., Buck, D., Deupree, J., Ellsworth, A., Furtado, D., Gunning, K., Lipman, A., Tramel, J., Whitman, N., Wilson, W.M. A Model Clinical Therapeutics Curriculum for Physician Assistant Training in the United States, 1998, 2nd edition.  

    Additional publications listed in Pub Med