Dr. Fox's Lab

Welcome to Dr. Howard Fox's laboratory

Collaborators
Research Goals
Funding
Techniques used in the laboratory
Personnel 
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Dr. Fox's Biographical Information

Collaborators
Howard E. Gendelman, MD, Pharmacology and Experimental Neuroscience, UNMC
Pawel Ciborowski, PhD, Pharmacology and Experimental Neuroscience, UNMC 
Shilpa Buch,PhD, Pharmacology and Experimental Neuroscience, UNMC 
Gary Siuzdak, The Scripps Research Institutes, San Diego
Cecilia Marcondes, The Scripps Research Institutes, San Diego 
Igor Grant, University of California, San Diego 
Scott Letendre, University of California, San Diego 
Ronald Ellis, University of California, San Diego

Research Goals

Funding
Proteomic Strategies for AIDS and Drug Abuse - HIV and METH CNS Synergy
Project 2: METH and the neuropathogenesis of SIV infection
PI: Howard S. Fox; Project 2 PI: Howard S. Fox
Source of funding: NIH/NIDA
The aims of the Program Project are to develop and use proteomic strategies to uncover the aspects of methamphetamine, HIV-1 and glial crosstalk (Project 1), methamphetamine and the neuropathogenesis of SIV infection (Project 2), and biomarkers in an HIV-1 infected drug abusing clinical cohort (Project 3).The aims of the Program Project are to develop and use proteomic strategies to uncover the aspects of methamphetamine, HIV-1 and glial crosstalk (Project 1), methamphetamine and the neuropathogenesis of SIV infection (Project 2), and biomarkers in an HIV-1 infected drug abusing clinical cohort (Project 3).

Chronic HIV infection and Aging in NeuroAIDS (CHAIN) Center
PI: Howard S. Fox
Source of funding: NIH/NIMH
This is a Center grant to provide Administrative and Core Support for scientists investigating NeuroAIDS.

Methamphetamine/SIV Interaction in the CNS
PI: Howard S. Fox
Source of funding: NIH/NIDA
We will test the hypothesis that METH administration alters the course of SIV infection in rhesus monkeys, examine the hypothesis that METH and SIV interact to promote CNS disease through effects on the virus/host interaction in the brain as well as alterations in dopaminergic systems, and est the hypothesis that METH and SIV interact to promote CNS pathophysiology by affecting the essential process of autophagy in neurons.

Molecular Aspects of CNS Dysfunction Due to SIV/HIV
PI: Howard S. Fox
Source of funding: NIH/NIMH
The major goals: 1) Investigate two mechanisms for neuronal damage identified from alterations in neuronal gene expression in microarray studies. 2) Study CNS function and changes in CNS gene expression during HAART treatment of SIV-infected monkeys. 3) Perform a longitudinal study to identify significant biomarkers in plasma and CSF that correlate with CNS disease.

SIV, IDO, and the Host Response in NeuroAIDS
PI: Howard S. Fox
Source of funding: NIH/NIMH
The goals are to examine the induction of IDO by SIV infection in primary macrophages; study in detail the mechanisms influencing the production and activity of IDO in macrophages and microglia; and investigate how IDO production leads to the persistence of productive viral infection in the CNS.

Techniques used in the laboratory
Cell biology
Molecular biology
Proteomics
Virology
Immunology
Neurobiology
Small and large animal models
Transcriptomics (global mRNA and miRNA profiling)

Personnel