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Research Interests
Representative Publications
Biographical Information
Visit Dr. Haorah's lab
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JAMES HAORAH, PhD
Associate Professor
Swanson Hall, 2040
985215 Nebraska Medical Center
Omaha, NE 68198-5215
Phone: 402-559-5406
E-mail: jhaorah@unmc.edu
Keywords: Alcohol, oxidative stress, blood-brain barrier, mitochondrial dysfunction, neuroinflammation, neurodegeneration, neurovascular biology
A Day in the Life... Dr. Haorah goes to school
When James Haorah was 11 years and 5 months old, a Catholic priest walked for seven miles to get to the village in remote northeast India where young James lived. It was a momentous day, and the priest was feted with great fanfare. This was partly a sign of deep respect, for a visiting dignitary, and partly because something this exciting didn’t happen every day. read more
Research Interests:
I am interested in understanding the molecular and biochemical signaling mechanisms of how alcohol-induced oxidative stress causes neuroinflammation, neuronal injury and neurodegeneration resulting from blood-brain barrier (BBB) dysfunction in the central nervous system. My laboratory is actively involved in investigating the effects of alcohol abuse on neurovascular components such as brain endothelial cells, the astrocytes, and the neurons supported by NIH/NIAAA financial funding.
To study the underlying mechanisms of alcohol abuse and BBB dysfunction. To study the combined CNS injury and interventions by alcohol abuse and HIV-1 infection. To study the mechanisms of alcohol-induced mitochondrial dysfunction and CNS injury. To study the mechanisms of neuroinflammation mediated by cyclooxygenase or lipoxygenase metabolism of fatty acids. To study the mechanisms of neurotoxicity by fatty acid ethyl esters in alcoholics. Improve the quality/style of teaching to Med/Pharm, physician assistance and graduate students.
Representative Publications
- Haorah J, Ramirez SH, Floreani NA, Gorantla S, Morsey B, and Persidsky Y (2008) Mechanism of Alcohol-induced Oxidative Stress and Neuronal Injury. Free Radical Biology and Medicine. 45 (11): 1542-50
- Ramirez SH, Heilman D, Morsey B, Potula R, Haorah J, and Persidsky Y (2008): Activation of Peroxisome Proliferator-Activated Receptor gamma (PPARγ)1 suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes. J Immunology. 180 (3): 1854-1865
- Haorah J, Schall K, Ramirez SH, and Persidsky Y (2008): Activation of Protein Tyrosine Kinases and Matrix Metalloproteinases Causes Blood-Brain Barrier Injury: Novel Mechanism for Neurodegeneration Associated with Alcohol Abuse Blood-Brain Barrier. Glia. 56 (1): 78-88
- Haorah J, Knipe B, Gorantla S, Zheng J and Persidsky Y (2007): Alcohol-induced blood- brain barrier dysfunction is mediated via inositol 1,4,5- triphosphate receptor IP3R-gated intracellular calcium release. J Neurochem. 100, 324-336
- Haorah J, Ramirez SH, Schall K, Smith D, Pandya R and Persidsky Y (2007): Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction. J Neurochem. 101(2): 566-76
- Persidsky Y, Heilman D, Haorah J, Zelivyanskaya M, Persidsky R, Weber GA, Shimokawa H, Kaibuchi K, Ikezu T. (2006): “Rho-mediated Regulation of Tight Junctions During Monocyte Migration Across Blood-Brain Barrier in HIV-1 Encephalitis (HIVE). Blood. 107:4770-80
Additional publications listed in Pub Med
Dr. Haorah's Bio
Visit Dr. Haorah's laboratory
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