James Haorah, PhD

James Haorah

Research Interests
Representative Publications
Biographical Information
Visit Dr. Haorah's lab

Associate Professor

Durham Research Center
985800 Nebraska Medical Center
Omaha, NE 68198-5215

Phone: 402-559-5406
E-mail: jhaorah@unmc.edu

Keywords: Alcohol, oxidative stress, blood-brain barrier, mitochondrial dysfunction, neuroinflammation, neurodegeneration, neurovascular biology

A Day in the Life... Dr. Haorah goes to school
When James Haorah was 11 years and 5 months old, a Catholic priest walked for seven miles to get to the village in remote northeast India where young James lived. It was a momentous day, and the priest was feted with great fanfare. This was partly a sign of deep respect, for a visiting dignitary, and partly because something this exciting didn’t happen every day. read more

Research Interests:
I am interested in understanding the underlying molecular, biochemical, and cellular mechanisms of oxidative injury in the cerebral vascular system and in the brain, resulting from alcohol or methamphetamine abuse, and HIV-1 infection. My research idea is driven by the hypothesis that disruption of the blood-brain barrier interface (i.e. leakiness of BBB) initiates the development of neurovascular inflammation and neurological disorders. This inflammatory process is further compounded by energy wasting in peripheral and neurovascular cells during pathologic condition. Thus, the preventive research is focused on minimizing oxidative stress, immune cell infiltration and improving the bio-fuel homeostasis in the brain. We examine these ideas in primary human monocytes/macrophages, brain endothelial cells, pericytes, astrocytes, microglia, and neurons in an in vitro system and in animal models of atherosclerotic and hemorrhagic stroke, and blast simulated pressure wave-induced traumatic brain injury.

 Representative Publications

  1. Haorah J, Ramirez SH, Floreani NA, Gorantla S, Morsey B, and Persidsky Y (2008) Mechanism of Alcohol-induced Oxidative Stress and Neuronal Injury. Free Radical Biology and Medicine. 45 (11): 1542-50
  2. Ramirez SH, Heilman D, Morsey B, Potula R, Haorah J, and Persidsky Y (2008): Activation of Peroxisome Proliferator-Activated Receptor gamma (PPARγ)1 suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes. J Immunology. 180 (3): 1854-1865
  3. Haorah J, Schall K, Ramirez SH, and Persidsky Y (2008): Activation of Protein Tyrosine Kinases and Matrix Metalloproteinases Causes Blood-Brain Barrier Injury: Novel Mechanism for Neurodegeneration Associated with Alcohol Abuse Blood-Brain Barrier. Glia. 56 (1): 78-88
  4. Haorah J, Knipe B, Gorantla S, Zheng J and Persidsky Y (2007): Alcohol-induced blood- brain barrier dysfunction is mediated via inositol 1,4,5- triphosphate receptor IP3R-gated intracellular calcium release. J Neurochem. 100, 324-336
  5. Haorah J, Ramirez SH, Schall K, Smith D, Pandya R and Persidsky Y (2007): Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction. J Neurochem. 101(2): 566-76
  6. Persidsky Y, Heilman D, Haorah J, Zelivyanskaya M, Persidsky R, Weber GA, Shimokawa H, Kaibuchi K, Ikezu T. (2006): “Rho-mediated Regulation of Tight Junctions During Monocyte Migration Across Blood-Brain Barrier in HIV-1 Encephalitis (HIVE). Blood. 107:4770-80

Additional publications listed in Pub Med

Dr. Haorah's Bio
Visit Dr. Haorah's laboratory

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