UNMC Pharmacology and Experimental Neuroscience

Research Focus Areas

Research in Department of Pharmacology focuses on diseases of the nervous system, infectious disease and autoimmunity, receptors, cell signaling and nanomedicine,  and emerging therapeutics .  The following lists specific areas of interest:

 

NEUROSCIENCE: Diseases of the Nervous System

Neurobiology and developmental neurosciences

Neuronal stem cell biology

Neurophysiology

Neurodegenerative diseases

Alzheimer's disease (transgenic models, neuropathology, and behavior)

Parkinson's disease (mouse models, therapy, and neuropathology) HIV-associated neurological disorders (mouse models, therapy, and neuropathology)

Neuroimmunology

Astrocyte and microglia biology

Neuron-glia interaction for disease protection and progression Blood-brain-barrier

Psychiatric diseases

Depression and therapeutic interventions

return to top of page

 

IMMUNOLOGY: Infectious Disease and Autoimmunity

HIV

  • HIV vaccine therapy
  • AIDS development in humanized immune system mouse models

Autoimmunity

Adjuvant therapy

Regulatory T cell immunity 

return to top of page 

 

PHARMACOLOGY:  Receptors, Cell Signaling and Nanomedicine

Characterization of receptors

N-methyl-D-aspartate receptors

Adrenergic receptors

Lysophosphatidic acid receptors

Regulation of receptors and cell signaling pathways

Developmental changes in receptors
Receptor desensitization and down-regulation
Cross-talk between receptor classes        

Receptors and cell signaling in specific diseases

Depression and anti-depressant drug action

Diabetic cardiomyopathy 

Pulmonary diseases

 return to top of page

 

EMERGING THERAPEUTICS

Cell-based drug delivery system

Nanoparticle drug delivery 

Gene therapy: Adenovirus and Adeno-associated viral vector 

Stem cell therapy

T cell based immunotherapy

return to top of page
Return to department home page

Content Last Updated On: 09/01/2009