Georgette Kanmogne, PhD

 Georgette_Kanmogne

 

 

 

 

 

 
Research Interests
Techniques used in lab
Representative Publications
Biographical Information
Visit Dr. Kanmogne's lab

GEORGETTE KANMOGNE, PhD
Associate Professor

Swanson Hall 4062
985215 Nebraska Medical Center
Omaha, NE 68198-5215

Phone: 402-559-4084
E-mail: gkanmogne@unmc.eduhttp://www.unl.edu/virologycenter/charles-wood-phd

Keywords: HIV, Blood-brain barrier, vascular biology

In the News:

UNMC Today, April 23, 2012
Meet UNMC Distinguished Scientist Georgette Kanmogne, M.D., M.P.H.

UNMC Today, March 13, 2012
Dr. Kanmogne aims to improve AIDS care in Cameroon

You Tube iconIn her own words, Dr. Kanmogne talks about her research in mechanisms of HIV-induced vascular dysfunction and neuroAIDs.


Research Interests

HIV-1 invades the brain in the early stages of infection and productively infects brain mononuclear phagocytes (MPs: macrophages and microglia). The virus, secreted proteins “virotoxins” and inflammatory cytokines/chemokines produced by infected MPs are thought to induce neuronal dysfunction and HIV-associated dementia (HAD). To elucidate the pathogenesis of HAD, it is important to understand by what mechanisms HIV-1 invades the brain.

Our laboratory is currently using different experimental paradigms to decipher the mechanisms mediating in blood-brain barrier (BBB) dysfunction and virus invasion of the central nervous system (CNS) in HAD. These approaches include specific cytotoxic effects of HIV-1 and virotoxins on the brain endothelium (including functional alterations of cytoskeleton and tight junction proteins) leading to increased BBB permeability, role of chemokine receptors and events occurring within endothelial cells during interaction with HIV-1 infected cells.

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Long-range Goals: 
  • Determine the role of blood- or brain derived HIV-1 and secreted viral products in the breach of BBB integrity and virus brain invasion.
  • Explore the molecular profiling of the BBB following HIV-1 brain infection
  • Determine the molecular interactions between HIV-1 and endothelial chemokine receptors
  • Explore the cell signaling pathways that lead to alterations of the BBB function
  • Design therapeutics approaches to prevent HIV-1-mediated dysfunction of the brain endothelium and viral entry into the central nervous system.

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Techniques used in the Laboratory:
  • Tissue Culture
  • Immunohistochemistry/ Laser
  • Confocal Microscopy
  • Cell Migration Assays
  • Southern & Western blot analysis
  • Autoradiography
  • ELISA, PCR, RT-PCR

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Representative Publications  
  1. Yang B., Singh S, Bressani R, Kanmogne GD Cross-talk between STAT1 and PI3K/AKT signaling in HIV-1-induced blood-brain barrier dysfunction: Role of CCR5 and implications for viral neuropathogenesis. J. Neurosci Res 2010 June 21
  2. Yang B, Akhter S, Chaudhuri A and Kanmogne GD. HIV-1 gp120 induces cytokine expression, leukocyte adhesion, and transmigration across the blood-brain barrier: modulatory effects of STAT1 signaling. Microvasc Res. 2008 77(2):212-9
  3. Chaudhuri A, Yang B, Gendelman HE, Persidsky Y and Kanmogne GD. STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier. Blood, 2008, 111(4): 2062-72
  4. Chaudhuri A, Duan F, Morsey B, Persidsky Y, and Kanmogne GD. HIV-1 activates pro-inflammatory and interferon inducible genes in human brain microvascular endothelial cells: Putative mechanisms of blood-brain barrier dysfunction. J Cereb Blood Flow Metab 2008, 28: 697-711
  5. Ricardo-Dukelow M, Kadiu-Kielen I, Wojciech R, Schautman J, Persidsky Y, Ciborowski P, Kanmogne GD and Gendelman HE. (2007). HIV-1 infected monocyte-derived macrophages affect the human brain microvascular endothelial cell proteome: New insights into blood-brain barrier dysfunction for HIV-1-associated dementia. J. Neuroimmunology 185: 37-46
  6. Kanmogne GD, Schall K, Leibhart J, Knipe B, Gendelman H, Persidsky Y (2007). HIV-1 gp120 compromises blood-brain barrier (BBB) integrity and enhance monocyte migration across BBB: Implication for viral neuropathogenesis. J Cereb Blood Flow Metab, 27, 123-134

Additional publications listed in Pub Med

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