Durham Research Center 3046
Keywords: drug delivery, nanomedicine, prodrug, theranostics, CNS, cancer, inflammation
My research interests mainly focus on chemically engineering novel biomaterials, drug delivery systems (DDS), nanomedicine, and low-molecular-weight prodrugs for the targeting theranostic application of CNS diseases, cancer, inflammatory diseases, and orofacial diseases, which benefit from my firm background in chemistry, and extensive training & experience in pharmacy and medicine.
Specific areas include
Wang JY, Wu QF, Li JP, Ren QS, Wang YL, Liu XM*. Photo-sensitive liposomes: chemistry and application in drug delivery. Mini Rev. Med. Chem. 2010, 10(2), 172-81.
Liu XM, Miller SC, Wang D. Beyond oncology – application of HPMA copolymers in non-cancerous diseases. Adv. Drug Del. Rev. 2009, 62(2), 258-71.
Liu XM, Quan LD, Tian J, Alnouti Y, Fu K, Thiele GM, Wang D. Synthesis and evaluation of a well-defined HPMA copolymer-Dexamethasone conjugate for effective treatment of rheumatoid arthritis. Pharm. Res. 2008, 25(12), 2910-9.
Liu XM, Wiswall AT, Rutledge JE, Akhter MP, Cullen DM, Reinhardt RA, Wang D. Osteotropic cyclodextrins for local bone regeneration. Biomaterials 2008, 29, 1686-92.
Liu XM, Thakur A, Wang D. Efficient synthesis of linear multifunctional poly(ethylene glycol) by copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition. Biomacromolecules 2007, 8(9), 2653-8.
Liu XM, Lee HT, Reinhardt RA, Marky LA, Wang D. Novel biomineral-binding cyclodextrins for controlled drug delivery in the oral cavity.J. Control. Release 2007, 122, 54-62.
Liu XM, Reinhardt RA, Wang D. Drug delivery strategies for common orofacial diseases. J. Drug Target. 2006, 14(8), 583-97
Liu XM, Yang B, Wang YL, Wang JY. Photoisomerisable cholesterol derivatives as photo-trigger of liposomes: effect of lipid polarity, temperature, incorporation ratio, and cholesterol. Biochem. Biophys. Acta, Biomembranes 2005, 1720(102), 28-34.
Liu XM, Yang B, Wang YL, Wang JY. New nanoscale pulsatile drug delivery system. Chem. Mater.2005, 17(11), 2792-5