Xinming Liu, PhD

Xinming_Liu

Research Interests
Representative Publications
Biographical Information

XINMING LIU, PhD
Assistant Professor

Durham Research Center 3046
985800 Nebraska Medical Center
Omaha, NE  68198-5800

Phone: 402-559-4562
Fax: 402-559-7495
E-mail:  xliu@unmc.edu

Keywords: cell and tissue targeted drug delivery, HIV and cancer nanomedicines, prodrug synthesis, pharmacokinetics, pharmacodynamics, magnetite-drug particles and theranostics‬‬


Research Interests:
Dr. Liu's research interests are multidisciplinary. He is engaged in medicinal and polymer chemistry for the development of novel biomaterials that will serve to improve clinical outcomes for a range of inflammatory, degenerative, cancerous and infectious disorders involving multiple organ systems.  His most recent works and an area of significant international interest and impact rest in the development of long acting cell targeted antiretroviral therapies. His highly innovative research has led to the development of innovative sustained release antiviral strategies for HIV disease treatments.  These have been developed from chemical approaches to testing of drug biodistribution and antiretroviral responses in humanized mouse models of human disease.  Prevention of HIV transmission and acquisition of new infections are other applications pursued. The research has gained international attention as adherence to dosing regimens is one of the major limiting factors for antiretroviral drug effectiveness. These studies have been sped through his comprehensive knowledge of bioengineering, for developing novel biomaterials, in utilizing cell targeted drug delivery systems (DDS), and most recently in the realization that through low-molecular-weight prodrugs enhancements can be realized in pharmacokinetics.  He has also developed theranostic application for HIV and a broader range of infectious and degenerative disorders. His current works are focused on using these technologies towards HIV eradication.

Specific areas include for HIV disease and beyond (neurodegenerative disorders, cancer, inflammatory and orofacial diseases)
•    Nanoformulated antiretroviral therapeutics (NanoART)
•    Liposomes, micelles and solid lipid nanoparticles (SLN)
•    Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles for theranostic application
•    Polymer therapeutics
•    Novel prodrug design

Representative Publications:

Guo D, Li T, McMillan J, Sajja BR, Puligujja P, Boska MD, Gendelman HE, Liu XM. Small magnetite antiretroviral therapeutic “SMART” nanoparticles facilitate magnetic resonance imaging monitoring of drug tissue biodistribution. Nanomedicine (London), 2013,Epub ahead of print.

Puligujja P, McMillan J, Kendrick L, Li T, Balkundi S, Veerubhotla RS, Edagwa BJ, Kabanov AV, Bronich TK, Gendelman HE and Liu XM.  Macrophage Folate Receptor-Targeted antiretroviral therapy facilitates drug entry, retention, antiretroviral activities and biodistribution aiding in the elimination of human immunodeficiency virus infection. Nanomedicine, 2013, Epub ahead of print.

Liu XM, Quan LD, Tian J, Laquer FC, Ciborowski P, Wang. The Syntheses of Click PEG - dexamethasone conjugates for the treatment of rheumatoid arthritis. Biomacromolecules 2010, 11(10), 2621-8.

Liu XM, Miller SC, Wang D. Beyond oncology – application of HPMA copolymers in non-cancerous diseases. Adv. Drug Del. Rev. 2009, 62(2), 258-71.

Liu XM, Quan LD, Tian J, Alnouti Y, Fu K, Thiele GM, Wang D. Synthesis and evaluation of a well-defined HPMA copolymer-Dexamethasone conjugate for effective treatment of rheumatoid arthritis. Pharm. Res. 2008, 25(12), 2910-9

Liu XM, Wiswall AT, Rutledge JE, Akhter MP, Cullen DM, Reinhardt RA, Wang D. Osteotropic cyclodextrins for local bone regeneration. Biomaterials 2008, 29, 1686-92

Liu XM, Thakur A, Wang D. Efficient synthesis of linear multifunctional poly(ethylene glycol) by copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition. Biomacromolecules 2007, 8(9), 2653-8

Liu XM, Lee HT, Reinhardt RA, Marky LA, Wang D. Novel biomineral-binding cyclodextrins for controlled drug delivery in the oral cavity.J. Control. Release 2007, 122, 54-62

Liu XM, Yang B, Wang YL, Wang JY. New nanoscale pulsatile drug delivery system. Chem. Mater. 2005, 17(11), 2792-5

Liu XM, Sun Q, Wang H, Zhang L, Wang JY. Microspheres of corn protein, zein, for an ivermectin drug delivery system. Biomaterials 2005, 26(1), 109-15. 


Dr. Liu's biographical information

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