Xinming Liu, PhD


Research Interests
Representative Publications
Biographical Information

Assistant Professor

Durham Research Center 3046
985800 Nebraska Medical Center
Omaha, NE  68198-5800

Phone: 402-559-4562
Fax: 402-559-7495

Keywords: drug delivery systems, nanomedicine, prodrugs, theranostics, CNS, HIV, neurodegenerative disorders, cancer, inflammation

Research Interests:
My research interests mainly focus on chemically engineering novel biomaterials, drug delivery systems (DDS), nanomedicine, and low-molecular-weight prodrugs for the targeting theranostic application of HIV, CNS diseases, cancer, inflammatory diseases, and orofacial diseases.  

Specific areas include:

  • Nanoformulated antiretroviral therapeutics (NanoART) for the targeted and long-acting therapy of HIV/AIDS.
  • Liposomes, micelles and solid lipid nanoparticles (SLN) for CNS, inflammatory, and orofacial diseases.
  • Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles for the targeting theranostic application of Cancer and CNS diseases.
  • Polymer therapeutics for CNS diseases, cancer, inflammatory diseases and orofacial diseases.
  • Novel targeting Prodrug design.

Representative Publications:

Guo D, Li T, McMillan J, Sajja BR, Puligujja P, Boska MD, Gendelman HE, Liu XM. Small magnetite antiretroviral therapeutic “SMART” nanoparticles facilitate magnetic resonance imaging monitoring of drug tissue biodistribution. Nanomedicine (London), 2013,Epub ahead of print.

Puligujja P, McMillan J, Kendrick L, Li T, Balkundi S, Veerubhotla RS, Edagwa BJ, Kabanov AV, Bronich TK, Gendelman HE and Liu XM.  Macrophage Folate Receptor-Targeted antiretroviral therapy facilitates drug entry, retention, antiretroviral activities and biodistribution aiding in the elimination of human immunodeficiency virus infection. Nanomedicine, 2013, Epub ahead of print.

Liu XM, Quan LD, Tian J, Laquer FC, Ciborowski P, Wang. The Syntheses of Click PEG - dexamethasone conjugates for the treatment of rheumatoid arthritis. Biomacromolecules 2010, 11(10), 2621-8.

Liu XM, Miller SC, Wang D. Beyond oncology – application of HPMA copolymers in non-cancerous diseases. Adv. Drug Del. Rev. 2009, 62(2), 258-71.

Liu XM, Quan LD, Tian J, Alnouti Y, Fu K, Thiele GM, Wang D. Synthesis and evaluation of a well-defined HPMA copolymer-Dexamethasone conjugate for effective treatment of rheumatoid arthritis. Pharm. Res. 2008, 25(12), 2910-9

Liu XM, Wiswall AT, Rutledge JE, Akhter MP, Cullen DM, Reinhardt RA, Wang D. Osteotropic cyclodextrins for local bone regeneration. Biomaterials 2008, 29, 1686-92

Liu XM, Thakur A, Wang D. Efficient synthesis of linear multifunctional poly(ethylene glycol) by copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition. Biomacromolecules 2007, 8(9), 2653-8

Liu XM, Lee HT, Reinhardt RA, Marky LA, Wang D. Novel biomineral-binding cyclodextrins for controlled drug delivery in the oral cavity.J. Control. Release 2007, 122, 54-62

Liu XM, Yang B, Wang YL, Wang JY. New nanoscale pulsatile drug delivery system. Chem. Mater. 2005, 17(11), 2792-5

Liu XM, Sun Q, Wang H, Zhang L, Wang JY. Microspheres of corn protein, zein, for an ivermectin drug delivery system. Biomaterials 2005, 26(1), 109-15. 

Dr. Liu's biographical information

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