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Research
Representative Publications
Biographical Information
Visit Dr. Poluektova's Laboratory
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LARISA POLUEKTOVA, MD, PhD
Associate Professor
Durham Research Center, Room 8015
985880 Nebraska Medical Center
Omaha, NE 68198-5880
Phone: 402-559-8926
E-mail: lpoluekt@unmc.edu
Keywords: hematopoietic stem cells, murine models for HIV-1, HIV-1 vaccines
Dr. Poluektova discusses how mice "are always teaching us" in the Spring 2012 issue of UNMC Discover. Read more "Of Mice and Men."
Research Interests:
HIV-1 pathogenesis, therapeutics and vaccines, humanized mice for translational research, stem cell transplantation. The long range goals are to development small animal models to study the pathogenesis of human-specific viral co-infection - HIV-1 and HCV/HBV
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Representative Publications
- Gorantla S, Makarov E, Roy D, Finke-Dwyer J, Murrin LC, Gendelman HE, Poluektova L. Immunoregulation of a CB2 receptor agonist in a murine model of NeuroAIDS. J. Neuroimm Pharm 2010 5(3):456-68
- Gorantla S, Makarov E, Finke-Dwyer J, Gebhart CL, Domm W, Dewhurst S, Gendelman HE, Poluektova LY. CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice. J. Immunol. 2010 Jun 15;184(12):7082-91
- Eggert D, Dash PK, Gorantla S, Dou H, Schifitto G, Maggirwar SB, Dewhurst S, Poluektova L, Gelbard HA, Gendelman HE. Neuroprotective activities of CEP-1347 in models of neuroAIDS. J Immunol.2010 Jan 15;184(2):746-56
- Eggert D, Dash PK, Serradji N, Dong CZ, Clayette P, Heymans F, Dou H, Gorantla S, Gelbard HA, Poluektova L, Gendelman HE. Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders. Neuroimmunol. 2009 Aug 18;213(1-2):47-59
- Gorantla S, Liu J, Wang T, Holguin A, Sneller H, Dou H, Kipnis J, Poluektova L, and Gendelman HE. Modulation of Innate Immunity by Copolymer-1 Leads to Neuroprotection in Murine HIV-1 Encephalitis. Glia 2008 Jan 15;56(2):223-32
- Gorantla S, Sneller H, Walters L, Sharp JG, Pirruccello SJ, West JT, Wood C, Dewhurst S, Gendelman HE, Poluektova L. Human immunodeficiency virus type 1 pathobiology studied in humanized Balb/c-Rag2-/-γc-/- mice. J Virol. 2007 Mar;81(6):2700-12 .
- Gorantla S, Liu J, Sneller H, Dou H, Holguin A, Smith L, Ikezu T, Volsky DJ, Poluektova L, Gendelman HE. Copolymer-1 induces adaptive immune anti-inflammatory glial and neuroprotective responses in a murine model of HIV-1 encephalitis. J Immunol. 2007 Oct 1;179(7):4345-56
Additional publications on PubMed
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Dr. Poluektova's biographical information
Visit Dr. Poluektova's laboratory
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