|Changhai Tian, PhD
Member Jialin Zheng MD, neurotoxicology laboratory
Durham Research Center II, 3069
Keywords: stem cells; mitochondria; neural progenitor cells; reprogramming
Research Interests: We recently developed mouse induced pluripotent stem cells (iPSCs) technology and investigated the region-specific differentiation of iPSCs to explore the application of iPSCs in neurodegenerative disorders. Moreover, we are exploring the possibility of directly reprogramming from somatic cells into neural progenitor cells (NPCs) by introducing a set of transcription factors, and also exploring the possibility of chemical reprogramming from somatic cells into pluripotent stem cells or neural progenitor cells by studying the proteomics between somatic cells and iPSCs.
Tian C, Wang Y, Sun L, Ma K and Zheng J. Reprogrammed Mouse Astrocytes Retain a Memory of Tissue Origin and Possess More Tendencies for Neuronal Differentiation than Reprogrammed MEFs. Protein & Cell, 2011 (Accepted).
Cui M, Huang Y, Tian C, Zhao Y, Zheng J. FOXO3a inhibits TNFa and IL-1b induced astrocyte proliferation: Implication for reactive astrogliosis.Glia, 2011, 59(4):641-54.
Erdmann N, Tian C, Huang Y,Zhao J, Herek S, Curthoys N and Zheng J. In Vitro Glutaminase regulation and mechanisms of glutamate generation in HIV-1 infected macrophage. J Neurochem. 2009,109 (2):551-61. PMCID: PMC2668921
Tian C, Erdmann N, Zhao J, Cao J, Peng H, Tsukamoto T and Zheng J. HIV-infected macrophages mediate neuronal apoptosis through mitochondrial glutaminase. J Neurochem. 2008,105 (3):994-1005. PMCID: PMC2614440
Tian C, Gao P, Zheng Y, Yue W, Wang X, Jin H, Chen Q. Redox status of thioredoxin-1 (TRX1) determines the sensitivity of human liver carcinoma cells (HepG2) to arsenic trioxide-induced cell death.Cell Res. 2008, 18 (4):458-471.
Nie C, Tian C, Zhao L, Xavier Petit, Mehrpour M and Chen Q. Cysteine 62 of bax is critical for its conformational activation and its pro-apoptotic activity in response to H2O2-induced apoptosis. J Biol Chem. 2008, 283(22):15359-15369.
Peng H, Whitney N, Wu Y, Tian C, Dou H and Zheng J. HIV-1-Infected and/or Immune-Activated Macrophage-Secreted TNF-a Affects Human Fetal Cortical Neural Progenitor Cell Proliferation and Differentiation. Glia, 2008, 56(8): 903-916. PMCID: PMC2644639
Whitney NP, Peng H, Erdmann NB, Tian C, Monaghan DT and Zheng JC. Calcium-permeable AMPA receptors containing Q/R-unedited GluR2 direct human neural progenitor cell differentiation to neurons.. FASEB J. 2008, 22(8): 2888-900. PMCID: PMC2493446
Zheng Y, Yamaguchi H, Tian C, Lee MW, Tang H, Wang HG, Chen Q. Arsenic trioxide (As2O3) induces apoptosis through activation of Bax in hematopoietic cells. Oncogene. 2005, 24 (20): 3339-47.
Zheng Y, Shi Y, Tian C, Jiang C, Jin H, Chen J, Almasan A, Tang H, Chen Q. Essential Role of the Voltage-dependent Anion Channel (VDAC) in Mitochondrial Permeability Transition Pore Opening and Cytochrome C Release Induced by Arsenic Trioxide. Oncogene. 2004, 23 (6): 1239-47. PMCID: PMC2913247