Changhai Tian, PhD

Changhai Tian

Research Interests
Representative Publications
Biographical Information
Visit the laboratory

 Changhai Tian, PhD
Instructor

Member Jialin Zheng MD, neurotoxicology laboratory

Durham Research Center II, 3069
985930 Nebraska Medical Center
Omaha, NE 68198-5930

Phone: 402-559-5910
E-mail:  ctian@unmc.edu

Keywords:  stem cells; mitochondria; neural progenitor cells; reprogramming 

Research Interests: We recently developed mouse induced pluripotent stem cells (iPSCs) technology and investigated the region-specific differentiation of iPSCs to explore the application of iPSCs in neurodegenerative disorders. Moreover, we are exploring the possibility of directly reprogramming from somatic cells into neural progenitor cells (NPCs) by introducing a set of transcription factors, and also exploring the possibility of chemical reprogramming from somatic cells into pluripotent stem cells or neural progenitor cells by studying the proteomics between somatic cells and iPSCs.

Representative Publications:

Tian C, Wang Y, Sun L, Ma K and Zheng J. Reprogrammed Mouse Astrocytes Retain a Memory of Tissue Origin and Possess More Tendencies for Neuronal Differentiation than Reprogrammed MEFs. Protein & Cell, 2011 (Accepted).

Cui M, Huang Y, Tian C, Zhao Y, Zheng J. FOXO3a inhibits TNFa and IL-1b induced astrocyte proliferation: Implication for reactive astrogliosis.Glia, 2011, 59(4):641-54.

Tian C, Murrin LC and Zheng J. Mitochondrial fragmentation is involved in methamphetamine-induced cell death in rat hippocampal neural progenitor cells. PLoS ONE. 2009; 4 (5):e5546. PMCID: PMC2677674

Erdmann N, Tian C, Huang Y,Zhao J, Herek S, Curthoys N and Zheng J. In Vitro Glutaminase regulation and mechanisms of glutamate generation in HIV-1 infected macrophage. J Neurochem. 2009,109 (2):551-61. PMCID: PMC2668921

Tian C, Erdmann N, Zhao J, Cao J, Peng H, Tsukamoto T and Zheng J. HIV-infected macrophages mediate neuronal apoptosis through mitochondrial glutaminase. J Neurochem. 2008,105 (3):994-1005. PMCID: PMC2614440

Tian C, Gao P, Zheng Y, Yue W, Wang X, Jin H, Chen Q. Redox status of thioredoxin-1 (TRX1) determines the sensitivity of human liver carcinoma cells (HepG2) to arsenic trioxide-induced cell death.Cell Res. 2008, 18 (4):458-471. 

Nie C,  Tian C, Zhao L, Xavier Petit, Mehrpour M and Chen Q. Cysteine 62 of bax is critical for its conformational activation and its pro-apoptotic activity in response to H2O2-induced apoptosis. J Biol Chem. 2008, 283(22):15359-15369.

Peng H, Whitney N, Wu Y, Tian C, Dou H and Zheng J. HIV-1-Infected and/or Immune-Activated Macrophage-Secreted TNF-a Affects Human Fetal Cortical Neural Progenitor Cell Proliferation and Differentiation. Glia, 2008, 56(8): 903-916. PMCID: PMC2644639 

Whitney NP, Peng H, Erdmann NB, Tian C, Monaghan DT and Zheng JC. Calcium-permeable AMPA receptors containing Q/R-unedited GluR2 direct human neural progenitor cell differentiation to neurons.. FASEB J. 2008, 22(8): 2888-900. PMCID: PMC2493446 

Zheng Y, Yamaguchi H, Tian C, Lee MW, Tang H, Wang HG, Chen Q. Arsenic trioxide (As2O3) induces apoptosis through activation of Bax in hematopoietic cells. Oncogene. 2005, 24 (20): 3339-47.

Zheng Y, Shi Y, Tian C, Jiang C, Jin H, Chen J, Almasan A, Tang H, Chen Q. Essential Role of the Voltage-dependent Anion Channel (VDAC) in Mitochondrial Permeability Transition Pore Opening and Cytochrome C Release Induced by Arsenic Trioxide. Oncogene. 2004, 23 (6): 1239-47. PMCID: PMC2913247