Visit Dr. Wilson's Lab
TONY W. WILSON, PhD
222 Clarkson Doctor's Building South
Omaha, NE 68198-8422
In the news:
Graduate Student Elizabeth Heinrichs-Graham earns 2014-15 University of Nebraska Presidential Graduate Fellow honor
UNMC Today, March 6, 2014
A Pioneer in Brain Imaging - Tony Wilson, PhD receives the Joseph P. Gilmore New Investigator award
UNMC Today, July 10, 2013
Investigators to Launch Clinical Trial Testing Parkinson's Therapy
Rick Ruggles/Omaha World-Herald staff writer
One-two punch vs. Parkinson's: meds and a machine
UNMC Today, May 24, 2013
UNMC Researcher uses neuroimaging for glimpse into Parkinson's Disease
Keywords: Pharmaco-MEG; functional connectivity; neural oscillatory dynamics; motor control; attention-deficit/hyperactivity disorder (ADHD); HIV-associated neurocognitive disorders (HAND); pathophysiology of Parkinson’s disease
Dr. Wilson’s Laboratory utilizes advanced functional and structural neuroimaging to understand how electrical activity in large-scale human brain networks gives rise to normal and aberrant cognitive processes. Current work in the Laboratory focuses on the application of neurophysiological imaging methods for understanding disease pathophysiology and for quantifying the neuronal changes that accompany select pharmacotherapies directed at these diseases.
The primary neurophysiological focus is on high-frequency cortical oscillations due to their known role in information processing and network level inter-regional communication. At present, major effort is directed toward using these methods to further understand the pathophysiology of attention-deficit/hyperactivity disorder (ADHD) and the primary mechanisms that underlie stimulant-mediated symptom suppression. Amphetamines are widely recognized as an effective treatment option for patients with ADHD, and by understanding their mechanism of action one can extract key insights on the basic pathophysiology.
Another line of work in Dr. Wilson’s Laboratory evaluates the impact that dopaminergic treatments have on cortical function and cortical-subcortical oscillatory activity in patients with mild to moderate Parkinson’s disease. Currently, it is widely recognized that Parkinson’s is associated with pathological levels of cortical-subcortical synchronization, and work in Dr. Wilson’s Laboratory focuses on how such neuronal synchronization is affected by dopamine-based treatments and disease progression.
Finally, Dr. Wilson’s Laboratory investigates candidate biomarkers for HIV-associated neurocognitive disorders (HAND). Between 35-70% of HIV-infected patients will develop cognitive impairments and the pathophysiology is not well understood. Currently, diagnoses are made by exclusion of other potential causes, as there are no diagnostic tests or specific biomarkers that can precisely pinpoint HAND. Thus, the goal of this work is to develop objective biomarkers of HAND that can be used for diagnoses, monitoring disease progression, and for testing new candidate treatments.
Selected Publications (since 2012): ** Mentored Student/Fellow
- Wilson TW, Heinrichs-Graham E, & Becker KM. (2014). Circadian modulation of motor-related beta oscillatory responses. NeuroImage, 102:531-539. PMID: 25128712
- **Heinrichs-Graham E, Kurz MJ, Becker KM, Santamaria PM, Gendelman HE, & Wilson TW. (in press). Hyper-synchrony despite pathologically-reduced beta oscillations in patients with Parkinson's disease: A pharmaco-magnetoencephalography study. Journal of Neurophysiology, 2014 Jul 9. [Epub ahead of print]. PMID: 25008416
- Kurz MJ, Becker KM, Heinrichs-Graham E, & Wilson TW. (in press). Neurophysiological abnormalities in the sensorimotor cortices during the motor planning and movement execution stages of children with cerebral palsy. Developmental Medicine & Child Neurology, 2014 Jun 14. [Epub ahead of print]. PMID: 24931008
- Kurz MJ, Heinrichs-Graham E, Arpin DJ, Becker KM, Wilson TW. (2014). Aberrant synchrony in the somatosensory cortices predicts motor performance errors in children with cerebral palsy. Journal of Neurophysiology, 111(3):573-579. PMID: 24225536
- **Heinrichs-Graham E, Franzen JD, Knott NL, White ML, Wetzel MW, & Wilson TW. (2014). Pharmaco-MEG evidence for attention related hyper-connectivity between auditory and prefrontal cortices in ADHD. Psychiatry Research: Neuroimaging, 221:240-245. PMID: 24495532.
- Wilson TW, Kurz MJ, & Arpin DJ. (2014). Functional specialization within the supplementary motor area: A fNIRS study of bimanual coordination. NeuroImage, 85:445-450. PMID: 23664948
- Kurz MJ, Wilson TW, Arpin DJ. (in press). An fNIRS exploratory investigation of the cortical activity during gait in children with spastic diplegic cerebral palsy. Brain & Development, 2014 Feb 5. PMID: 24508407
- **Becker KM, Heinrichs-Graham E, Fox HS, Robertson KR, Sandkovsky U, O'Neill J, Swindells S, & Wilson TW. (2013). Decreased MEG beta oscillations in HIV-infected older adults during the resting state. Journal of Neurovirology, 19(6):586-94. [Cover Article]. PMID: 24297500
- **Heinrichs-Graham E, Wilson TWCA, Santamaria PM, Heithoff SK, Torres-Russotto D, Hutter-Saunders JA, Estes KA, Meza JL, Mosley RL, & Gendelman HE. (2014). Neuromagnetic evidence of abnormal movement-related beta desynchronization in Parkinson's disease. Cerebral Cortex, 24:2669-2678. PMID: 23645717
- Wilson TW, Heinrichs-Graham E, Robertson KR, Sandkovsky U, O’Neill J, Knott NL, Fox HS, & Swindells S. (2013). Functional brain abnormalities during finger-tapping in HIV-infected older adults: A magnetoencephalography study. Journal of Neuroimmune Pharmacology, 8:965-974. PMID: 23749418
- Wilson TW, Fox HS, Robertson KR, Sandkovsky U, O’Neill J, Heinrichs-Graham E, Knott NL, & Swindells S. (2013) Abnormal MEG oscillatory activity during visual processing in the prefrontal cortices and frontal eye-fields of the aging HIV brain. PLoS One 8(6):e66241. PMID: 23840428
- Wilson TW, Heinrichs-Graham E, White ML, Knott NL, Wetzel MW. (2013). Estimating the passage of minutes: Deviant oscillatory frontal activity in medicated and un-medicated ADHD. Neuropsychology, 27:654-665. PMID: 24040925
- Madhavan D, Heinrichs-Graham E, Wilson TW. (2013). Whole-brain functional connectivity increases with extended duration of focal epileptiform activity. Neuroscience Letters, 542:26-29. PMID: 23506687
- **Franzen JD, Heinrichs-Graham E, White ML, Wetzel MW, Knott NL, & Wilson TW. (2013). Atypical coupling between posterior regions of the default-mode network in ADHD: A pharmaco-MEG study. Journal of Psychiatry and Neuroscience, 38:333-340. PMID: 23611175
- Wilson TW, Franzen JD, Heinrichs-Graham B, White ML, Knott NL, & Wetzel MW. (2013). Broadband neurophysiological abnormalities in the prefrontal region of the default-mode network in adults with ADHD. Human Brain Mapping, 34:566-574. PMID: 22102400
- Wilson TW, Wetzel MW, White ML, & Knott NL. (2012). Gamma-frequency neuronal activity is diminished in adults with attention-deficit/hyperactivity disorder: A pharmaco-MEG study. Journal of Psychopharmacology, 26(6):771-777. PMID: 22219219
- **Franzen JD, Wilson TW. (2012). Amphetamines modulate prefrontal γ oscillations during attention processing. NeuroReport, 23(12):731-735. PMID: 22776904
- Wilson TW, Heinrichs-Graham E, Aizenberg MR. (2012). Potential role for magnetoencephalography in distinguishing low- and high-grade gliomas: A preliminary study with histopathological confirmation. Neuro-Oncology, 14(5):624-630. PMID: 22447561
- **Heinrichs-Graham E, & Wilson TW. (2012). Presence of strong harmonics during visual entrainment: A MEG study. Biological Psychology, 91:59-64. PMID: 22569101
- Kurz MJ, Wilson TW, Corr B, Volkman KG. (2012). Neuromagnetic activity of the somatosensory cortices associated with body-weight-supported treadmill training in children with cerebral palsy. Journal of Neurologic Physical Therapy,36(4):166-172. PMID: 22743850
- Kurz MJ, Wilson TW, & Arpin D. (2012). Stride-time variability and sensorimotor cortical activation during walking. NeuroImage, 59:1602-1607. PMID: 21920441
Other Publications Important to the Field:
- Wilson TW, Godwin DW, Czoty PW, Nader MA, Kraft RA, Buchheimer NC, & Daunais JB. (2009). An MEG investigation of somatosensory processing in the rhesus monkey. NeuroImage, 46:998-1003. PMCID: PMC2692724
- Wilson TW, Hernandez OO, Asherin RM, Teale PD, Reite ML, & Rojas DC. (2008). Cortical gamma generators suggest abnormal auditory circuitry in early-onset psychosis. Cerebral Cortex, 18:371-378. PMCID: PMC2648842
- Wilson TW, Rojas DC, Reite ML, Teale PD, & Rogers SJ. (2007). Children and adolescents with autism exhibit reduced MEG steady-state gamma responses. Biological Psychiatry, 62:192-297. PMCID: PMC2692734 Also see: Uhlhaas PJ, & Singer W. (2007). What do disturbances in neural synchrony tell us about autism? Biological Psychiatry, 62:190–191. [Editorial that highlights our primary findings]
Additional publications in PubMed.
Dr. Wilson's biographical information
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