Honghong Yao, PhD

Honghon Yao

Research Interests
Representative Publications
Biographical Information

HONGHONG YAO, PhD
Assistant Professor

Laboratory of Shilpa Buch, PhD

Durham Research Center, 8012
985880 Nebraska Medical Center
Omaha, NE  68198-5880

402-559-3167
E-mail:  hyao@unmc.edu


 

UNMC Today, April 22, 2011
Meet UNMC New Investigator Honghong Yao, Ph.D.

Keywords: HIV, drugs of abuse (cocaine, morphine)

Research Interests: How HIV and its proteins can synergize with drugs of abuse to cause more severe damage in the brain.


Representative Publications:

Yao H, Allen JE, Zhu X, Callen S and Buch S (2009) Cocaine and HIV-1 gp120 mediate neurotoxicity through overlapping signaling pathways. J Neurovirology.15:164-75. PMCID: PMC2856938

Yao H, Peng F, Dhillon N, Callen S, Bokhari S, Zhu X, Buch S  (2009) Involvement of TRPC channels in CCL2-mediated neuroprotection against Tat toxicity. J Neuroscience. 2009 29:1657-69. PMCID: PMC2768421

Yao H, Buch SJ. Chronic Cocaine exposure decreased cell proliferation in hippocampus of HIV Tg rats. Proceedings of the ICBNAID meeting

Yao H, Bethel-Brown C and Buch SJ. (2009) Cocaine exposure caused dendritic varicosity formation in rat primary hippocampal neurons. Am. J. Infectious Diseases. 15:26-30. PMCID: PMC2749690

Bokhari S, Yao H, Bethel-Brown C, Peng F, Williams R, Dhillon NK, Hegde R, Anil Kumar A, Buch S. (2009) Morphine enhances Tat-induced Activation in Murine Microglia. J Neurovirology. 15:219-28.

Yao H, Peng F, Zhu X, Buch S (2009) TRPC channel-mediated neuroprotection by PDGF involves Pyk2/ERK/CREB pathway. Cell Death Differ. 16:1681-93. PMCID: PMC2783976

Williams R, Yao H, Dhillon NK, Buch S. HIV-1 Tat co-operates with IFN-γ and TNF-α to increase CXCL10 in human astrocytes. Plos ONE. 2009, 28;4: e5709 . PMCID: PMC2684622

Zhu X*, Yao H*, Peng F, Callen S, Buch S (2009) PDGF-mediated protection of SH-SY5Y cells against Tat toxin involves regulation of extracellular glutamate and intracellular calcium. Toxicol Appl Pharmacol. 240:286-91. (* Co-first coauthor) PMCID: PMC2753679

Yao H, Yang YJ, Bethel-Brown C, Gong N, Funa K, Kim KJ, Gendelman HE, Su TP, Wang JQ, and Buch S (2009). Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration. Blood. 115:4951-62. PMCID: PMC2890169

Peng F*, Yao H*, Bai X, Zhu X, Reiner BC, Beazely M, Funa K, Xiong H, Buch S (2010) Platelet-derived growth factor-mediated induction of the synaptic plasticity gene Arc/Arg3.1.J Biol Chem. 285:21615-24. (* Co-first coauthor)

Yao H, Bethel-Brown C, Li CZ, Buch SJ. (2010) HIV Neuropathogenesis: a Tight Rope Walk of Innate Immunity. J Neuroimmune Pharmacol. 5(4):489-95. PMCID: PMC3121574

Yang Y*, Yao H*, Lu Y, Wang C, and Buch S. (2010) Cocaine potentiates astrocyte toxicity mediated by human immunodeficiency virus (HIV-1) protein gp120 in rat primary astrocytes. Plos ONE 15; 5: e13427. (* Co-first coauthor). PMCID: PMC2955538

Yao H, Duan M, Buch. (2011) Cocaine-mediated induction of platelet-derived growth factor: implication for increased vascular permeability.Blood 117(8):2538-47 

Bethel-Brown C, Yao, H, Callen S, Lee YH, Dash, PK, Kumar, A, Buch. (2011) HIV-1 Tat-Mediated Induction of Platelet-Derived Groth Factor in Astrocytes:  Role of Early Growth Response Gene 1. J. Immunol. 2011 [Epub ahead of print]

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