Sowmya Yelamanchili, PhD

Sowmya_Yelamanchili

Research Interests
Representative Publications
Biographical Information

Sowmya Yelamanchili, PhD
Instructor

Member, Howard Fox, MD, PhD's  laboratory

Durham Research Center, 3022
985800 Nebraska Medical Center
Omaha, NE  68198-5800

Phone: 402-559-5348
E-mail: syelamanchili@unmc.edu


Keywords: microRNAs in neurodegenerative diseases, HIV, Parkinson's Disease
Research Interests:

My current research interest focuses on elucidating the role of microRNAs in neurological diseases. One such ongoing project is the role of the microRNA miR-21 that we have shown as a crucial effector of HIV induced CNS dysfunction (Yelamanchili et al. 2010 Cell Death & Disease). Another aspect I am currently steering my research is the role of these microRNAs in neuronal development - especially defining their role in neural fate determination. One such novel microRNA is miR-1290, which drives neuronal differentiation in human progenitor cells. We have shown that overexpression of miR-1290 leads to neuronal differentiation while, knocking it down resulted in progenitor proliferation and neuronal death. In summary, elucidating the functional aspects of microRNAs and characterizing their targets for potential therapeutic interventions in the future is my long-term research goal.


Representative Publications:

Chaudhuri AD, Yelamanchili SV, Marcondes MC and Fox HS (2013). Upregulation of MicroRNA-142 in Simian Immunodeficiency Virus Encephalitis leads to Repression of Sirtuin1. FASEB J. 2013 Jun 10.

Chaudhuri AD, Yelamanchili SV and Fox HS (2013). Combined Fluorescent in situ Hybridization for detection of microRNAs and Immunofluorescent Labeling for Cell-Type Markers. Frontiers in Cell. Neurosci. Sep 23;7:160

Chaudhuri AD, Yelamanchili SV and Fox HS (2013). MicroRNA-142 Reduces Monoamine Oxidase A Expression and Activity in Neuronal Cells by Downregulating SIRT1. Plos One, In press.

Hu G, Yao H, Chaudhuri AD, Duan M, Yelamanchili SV, Wen H, Cheney PD, Fox HS, Buch S (2012). Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated neuronal dysfunction.  Cell Death and Disease. Aug 30; 3:e381. PMCID: PMC3434655

Yelamanchili SV, Chaudhuri AD A, Flynn C, Fox HS (2011). Upregulation of Cathepsin D in the caudate nucleus of primates with experimental parkinsonism. Molecular Neurodegeneration, Jul 21; 6:52 PMCID: PMC3160400

Yelamanchili SV, Datta-Chaudhari A, Chen L, Xiong H and Fox HS. MicroRNA-21 dysregulates the expression of MEF2C in neurons in monkey and human SIV/HIV neurological disease. Cell Death Dis., 2010, 1 (9) e77. PMCID: PMC3002786

Yelamanchili SV and Fox HS. Defining Larger Roles for "Tiny" RNA Molecules: Role of miRNAs in Neurodegeneration Research. J. Neuroimmune Pharmacol., 2010, 5:63-69.PMCID:  PMC2881294

Darna M, Schmutz I, Richter K, Yelamanchili SV, Pendyala G, Holtje M, Albrecht U, Ahnert-Hilger G. (2009) Time-of-day dependent sorting of vesicular glutamate transporter to the plasma membrane. J Biol Chem, 284(7):4300-07

Darna M, Schmutz I, Richter K, Yelamanchili SV, Pendyala G, Holtje M, Albrecht U, Ahnert-Hilger G (2009). Time-of-day dependent sorting of vesicular glutamate transporter to the plasma membrane. J Biological Chemistry 284(7): 4300-7 Publication was not directly supported by NIH.

Yelamanchili SV, Pendyala G, Brunk I, Darna M, Albrecht U, Ahnert-Hilger G (2006) “Differential sorting of the Vesicular Glutamate Transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period2”, Journal of Biological Chemistry 281, 15671-15679

Yelamanchili SV, Reisinger C, Becher A, Sikorra S, Bigalke H, Binz T, Ahnert-Hilger G (2005) “The C-terminal transmembrane region of synaptobrevin binds synaptophysin from adult synaptic vesicles”, European Journal of Cell Biology 4, 467-75

Reisinger C, Yelamanchili SV, Hinz B, Mitter D, Becher A, Bigalke H, Ahnert-Hilger G (2004) “The synaptophysin/synaptobrevin complex dissociates independently of neuroexocytosis” Journal of Neurochemistry 1, 1-8

Mitter D, Reisinger C, Hinz B, Hollmann S, Yelamanchili SV, Treiber-Held S, Ohm TG, Herrmann A, Ahnert-Hilger G (2003). The synaptophysin/synaptobrevin interaction critically depends on the cholesterol content. Journal of Neurochemistry 1, 35-42

Mitter D, Reisinger C, Hinz B, Hollmann S, Yelamanchili SV, Treiber-Held S, Ohm TG, Herrmann A, Ahnert-Hilger G (2003). The synaptophysin/synaptobrevin interaction critically depends on the cholesterol content. Journal of Neurochemistry 1, 35-42

Book Chapter:
Yelamanchili SV
, Piamonte V, Nayak S, Tanaka N, Zhu Q, Jones K, Le H & Panda S (2008). “Melanopsin signaling and non-visual ocular photoreception”. Methods chapter in “Signal transduction of the retina “, Taylor and Francis Group.

Additional publications in PubMed

 

 

   

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