Collaborators of Mahato's Lab
We have collaboration with Dr. Batra’s lab for devising strategies for the treatment of pancreatic cancer. Dr. Batra’s laboratory focuses on defining multifaceted roles of tumor associated antigens (MUC4 and PD2/hPaf1) in the pathogenesis of various types of cancers. The overall goals of our collaboration are to elucidate the molecular mechanisms involved in the proliferation of pancreatic cancer and, to identify miRNAs involved in chemoresistance, and metastasis in human pancreatic cancer tissue specimens. miRNAs are non-coding small ribonucleotides which play a multifunctional role in inducing drug resistance and metastasis in almost any type of cancer.
We share a common goal with Dr. Hollingsworth on designing innovative and effective treatments for pancreatic cancer. His laboratory specializes in modern techniques of molecular biology, biochemistry, cell biology, and immunology to develop a comprehensive program of investigation into the biology of normal and diseased pancreatic ductal epithelial cells. The major focus of our research is to identify deregulated miRNAs in human pancreatic tissues and to design a delivery system for miRNAs and small molecules for treatment of pancreatic cancer.
Dr. Sasson is an Associate Professor and Chief Gastrointestinal Surgery in the Department of Surgery at UNMC. Dr. Sasson has extensive experience in treating pancreatic cancers and our collaboration bring us his expertise towards developing tumor models using human pancreatic cancer tissues and their subsequent treatment with the designed formulations.
Nora Sarvetnick, Ph.D. is a stem cell researcher and transplant immunologist at Department of Surgery-Transplant, UNMC. We have collaboration with Dr. Sarvetnick to overcome the challenges posed by immune responses, which limit the success of islet transplantation for treatment of diabetes. Immune responses at the time of islet transplantation could lead to rejection of the graft. We are interested in increasing our understanding in the specific events that trigger immune stimulation and result in failure of the transplant surgeries and thereby design novel therapies for subsequent treatment.
Dr. Lin is a professor in Biochemistry and Molecular Biology and Eppley Institute for Cancer, UNMC. His lab focuses on the molecular mechanism of cell growth regulation via tyrosine phosphorylation and Redox signal transduction mediating androgen action for understanding mechanism of multi-step carcinogenesis of prostate epithelium. Our collaboration stands on designing the targeted treatments for the prostate cancer.
Dr. Singh’s research focuses on the mechanism(s) that regulate the process of metastasis which is a highly selective process regulated by interrelated mechanisms. Our collaboration with Dr. Singh brings us his valuable expertise in understanding and thus designing novel therapeutics for targeting metastasis.
We are working with Professor Duane Miller to design/synthesize novel lipid, polymer and peptide-based carrier molecules for delivery of proteins, oligonucleotides and genes to different disease targets. Dr. Miller is H. S. Van Vleet Professor, Department Chair and Associate Dean, College of Pharmacy, University of Tennessee Health Science Center, Memphis (UTHSC), Memphis. Dr. Miller has extensive experience in designing and synthesis of new drug molecules.
Dr. Wei Li
We are working with Dr. Wei Li to design/synthesize novel polymeric nanoparticles to treat melanoma. Melanoma is an extremely aggressive type of skin cancer with a high potential of metastasis and ability to develop resistance to most of the known anticancer agents. Metastatic melanoma is associated with poor prognosis and 5 year survival rate of less than 20%. The goal of this project is to develop novel thiazole analogs which can be used to treat melanoma and enhance their delivery to melanoma tumors using polymeric nanoparticles. Dr. Li has extensive experience in molecular modeling, organic synthesis, in vitro and in vivo biological assays.
Dr. Stephan W. Behrman
Dr. Behrman is a Professor of Surgery in the Department of Surgery at the University of Tennessee Health Science Center, Memphis, TN. Dr. Behrman has an extensive experience in treating pancreatic cancer patients and an abiding interest in understanding the pathophysiology of the disease. His collaboration is valuable to us for the development of tumor models using human pancreatic cancer tissues and their subsequent treatment with the designed formulations.
Dr. Chae-Yuk Yun
Dr. Yun is a Professor in the Department of Bioengineering at Hanyang University, Seoul and has extensive experience in molecular biology, viral vector construction, gene cloning and generation of bipartite adenoviral vectors.
We are working with Dr. Tomoko Fujiwara to design/synthesize novel polymers for delivery of small molecules, proteins, oligonucleotides and genes to different disease targets. Dr. Fujiwara is an Assistant Professor in Department of Chemistry, The University of Memphis. Dr. Fujiwara has extensive experience in design and synthesis of new biomaterials.