Elena V. Batrakova, Ph.D.

Research Associate Professor

BatrakovaDepartment of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
Durham Research Center
First Floor, Room #1038
985830 Nebraska Medical Center
Omaha, NE 68198-5830
Tel: (402) 559-9361
Fax: (402) 559-9365

Teaching Activities:
Dr. Batrakova mentors graduate students and teaches in Innovative Drug Delivery (PHSC851).

Research Activities/Interests:
The main focus of Dr. Batrakova's research  is development of developing a cell-mediated active delivery of therapeutic polypeptides to the brain for treatment of Parkinson's Disease using inflammatory-response cells as vehicles. Dr. Batrakova is also devoted to the development of a new drug delivery polymer-based system of chemotherapy to treat multi-drug resistant (MDR) tumors, and CNS disorders.

Please visit the Nanomedicine Group Website for further information.

Recent Publications:

  1. Batrakova, E.V.; Li, S.; Brynskikh, A.M.; Sharma, A.K.; Li, Y.; Boska, M.; Mosley, R.L.; Alakhov, V.; Yu; Gendelmen, H.D.; Kabanov, A.V.; Effects of Pluronic and Doxorubicin on Drug Uptake, Cellular Metabolism, Apoptosis and Tumor Inhibition in Animal Models of MDR Cancers. J Control Release. Jan 2010
  2. Price, T.O.; Farr, S.A.; Yi, X.; Vinogradov, S.V.; Batrakova, E.V.; Banks, W.A.; Kabanov, A.V.; Transport Across the Blood-Brain Barrier of Pluronic Leptin. J Pharmacol Exp Ther., 333 (1), pp. 253-263. Jan 2010
  3. Brynskikh, A.M.; Li, S.; Zhao, Y.; Mosley, R.L.; Boska, M.B.; Klyachko, N.L.; Kabanov, A.V.; Gendelman, H.E.; Batrakova, E.V.; A Macrophage-based Delivery System of Antioxidant Enzymes for Parkinson's Disease: Therapeutic Effect In Vivo. Nanomedicine, 5 (3): pp. 379-396, April 2010
  4. Luxenhofer, R.; Schulz, A.; Li, S.; Bronich, T.K.; Batrakova, E.V.; Jordan, R.; Kabanov, A.V.; Doubly Amphiphilic Polymers as High-Capacity Delivery Systems for Hydrophobic Drugs. Biomaterials, 31 (18): pp. 4972-4979. Jun 2010
  5. Rosenbaugh, E.; Roat, J.; Gao, L.; Yang, R.F.; Manickam, D.S.; Yin, J.X.; Schultz, H.D.; Bronich, T.K.; Batrakova, E.V.; Kabanov, A.V.; Zucker, I.H.; Zimmerman, M.C.; The Attenuation of Central Angiotensin II-Dependent Pressor Response and Intra-Neuronal Signaling by Intracarotid Injection of Nanoformulated Copper/Zinc Superoxide Dismutase. Biomaterials. April 2010
  6. Zhao, Y.; Haney, M.; Klyachko, N.L.; Manickam, D.S.; Li, S.; Booth, S.L.; Zimmerman, M.C.; Mosley, R.L.; Kabanov, A.V.; Gendelman, H.E.; Batrakova, E.V.; Optimization of Polyelectrolyte Complexes of Redox Enzymes and Block Copolymers for Macrophage-mediated Delivery in Parkinson's Disease. Nanomedicine (Lond) 6 (1): pp. 25-42. January 2011
  7. Batrakova, E.V.; Gendelman, H.E.; Kabanov, A.V.; Cell-Mediated Drug Delivery. Expert Opinion on Drug Delivery, 8 (4): pp. 1-19. 2011
  8. Haney, M.J.; Zhao, Y.; Li, S.; Higginbotham, S.M.; Booth, S.L.; Han, H-Y.; Vetro, J.A.; Mosley, R.L.; Kabanov, A.V.; Gendelman, H.E.; Batrakova, E.V.; Macrophage Transfer of Catalase Nanoparticles to Neural Cells in Cell-Mediated Therapy of Parkinson's Disease. Nanomedicine, in press. 2011
  9. Klyachko, N.L.; Manickam, D.S.; Brynskikh, A.M.; Uglanova, S.V.; Li, S.; Higginbotham, S.M.; Bronich, T.K.; Batrakova, E.V.; Kabanov, A.V.; Cross-Linked Antioxidant Nanozymes for Improved Delivery to CNS; Nanomedicine: Nanotechnology, Biology and Medicine. June 2011
  10. Banks, W.A.; Gertler, A.; Soloman, G.; Niv-Spector, L.; Yacobovitz, M.; Yi, X.; Batrakova, E.V.; Vinogradov, S.V.; Kabanov, A.V.; Principles of Strategic Drug Delivery to the Brain (SDDB): Development of Orexigenic and Anorectic Analogs of Leptin, Physiol Behav. June 2011