Elena V. Batrakova, Ph.D.

Elena V. Batrakova, Ph.D.

Elena V. Batrakova, Ph.D.Batrakova
Research Associate Professor
Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
Durham Research Center
First Floor, Room #1038
985830 Nebraska Medical Center
Omaha, NE 68198-5830
Tel: (402) 559-9361
Fax: (402) 559-9365
ebatrako@unmc.edu

Teaching Activities:
Dr. Batrakova mentors graduate students and teaches in Innovative Drug Delivery (PHSC851).

Research Activities/Interests:
The main focus of Dr. Batrakova's research  is development of developing a cell-mediated active delivery of therapeutic polypeptides to the brain for treatment of Parkinson's Disease using inflammatory-response cells as vehicles. Dr. Batrakova is also devoted to the development of a new drug delivery polymer-based system of chemotherapy to treat multi-drug resistant (MDR) tumors, and CNS disorders.

Please visit the Nanomedicine Group Website for further information.

Recent Publications:

  1. Batrakova, E.V.; Li, S.; Brynskikh, A.M.; Sharma, A.K.; Li, Y.; Boska, M.; Mosley, R.L.; Alakhov, V.; Yu; Gendelmen, H.D.; Kabanov, A.V.; Effects of Pluronic and Doxorubicin on Drug Uptake, Cellular Metabolism, Apoptosis and Tumor Inhibition in Animal Modesl of MDR Cancers. J Control Release. Jan 2010
  2. Price, T.O.; Farr, S.A.; Yi, X.; Vinogradov, S.V.; Batrakova, E.V.; Banks, W.A.; Kabanov, A.V.; Transport Across the Blood-Brain Barrier of Pluronic Leptin. J Pharmacol Exp Ther., 333 (1), pp. 253-263. Jan 2010
  3. Brynskikh, A.M.; Li, S.; Zhao, Y.; Mosley, R.L.; Boska, M.B.; Klyachko, N.L.; Kabanov, A.V.; Gendelman, H.E.; Batrakova, E.V.; A Macrophage-based Delivery System of Antioxidant Enzymes for Parkinson's Disease: Therapeutic Effect In Vivo. Nanomedicine, 5 (3): pp. 379-396, April 2010
  4. Luxenhofer, R.; Schulz, A.; Li, S.; Bronich, T.K.; Batrakova, E.V.; Jordan, R.; Kabanov, A.V.; Doubly-Amphiphilic Polymers as High-Capacity Delivery Systems for Hydrophobic Drugs. Biomaterials, 31 (18): pp. 4972-4979. Jun 2010
  5. Rosenbaugh, E.; Roat, J.; Gao, L.; Yang, R.F.; Manickam, D.S.; Yin, J.X.; Schultz, H.D.; Bronich, T.K.; Batrakova, E.V.; Kabanov, A.V.; Zucker, I.H.; Zimmerman, M.C.; The Attenuation of Central Angiotensin II-Depdendent Pressor Response and Intra-Neuronal Signaling by Intracarotid Injection of Nanoformulated Copper/Zinc Superoxide Dismutase. Biomaterials. April 2010
  6. Zhao, Y.; Haney, M.; Klyachko, N.L.; Manickam, D.S.; Li, S.; Booth, S.L.; Zimmerman, M.C.; Mosley, R.L.; Kabanov, A.V.; Gendelman, H.E.; Batrakova, E.V.; Optimization of Polyelectrolyte Complexes of Redox Enzymes and Block Copolymers for Macrophage-mediated Delivery in Parkinson's Disease. Nanomedicine (Lond) 6 (1): pp. 25-42. January 2011
  7. Batrakova, E.V.; Gendelman, H.E.; Kabanov, A.V.; Cell-Mediated Drug Delivery. Expert Opinion on Drug Delivery, 8 (4): pp. 1-19. 2011
  8. Haney, M.J.; Zhao, Y.; Li, S.; Higginbotham, S.M.; Booth, S.L.; Han, H-Y.; Vetro, J.A.; Mosley, R.L.; Kabanov, A.V.; Gendelman, H.E.; Batrakova, E.V.; Macrophage Transfer of Catalase Nanoparticles to Neural Cells in Cell-Mediated Therapy of Parkinson's Disease. Nanomedicine, in press. 2011
  9. Klyachko, N.L.; Manickam, D.S.; Brynskikh, A.M.; Uglanova, S.V.; Li, S.; Higginbotham, S.M.; Bronich, T.K.; Batrakova, E.V.; Kabanov, A.V.; Cross-Linked Antioxidant Nanozymes for Improved Delivery to CNS; Nanomedicine: Nanotechnology, Biology and Medicine. June 2011
  10. Banks, W.A.; Gertler, A.; Soloman, G.; Niv-Spector, L.; Yacobovitz, M.; Yi, X.; Batrakova, E.V.; Vinogradov, S.V.; Kabanov, A.V.; Principles of Strategic Drug Delivery to the Brain (SDDB): Development of Orexigenic and Anorectic Analogs of Leptin, Physiol Behav. June 2011