Yuxiang Dong, Ph.D.

Research Assistant Professor

DongDepartment of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
986025 Nebraska Medical Center
Omaha, NE 68198-6025
402-559-3516 (Lab)
402-559-9543 (Fax)
ydong@unmc.edu

Teaching Activities:
Dr. Dong is currently pursuing teaching opportunities in the areas of Medicinal Chemistry and Organic Chemistry.

Research Activities/Interests:
Design and synthesis of novel bioactive compounds; development of novel organic reactions; optimization of chemical reactions and processes.

Recent Publications:

  1. Vennerstrom, J.L.; Arbe-Barnes, S.; Brun, R.; Charman, S.A.; Chiu, F.C.K.; Chollet, J.; Dong, Y.; Dorn, A.; Hunziker, D.; Matile, H.; McIntosh, K.; Padmanilayam, M.; Santo Tomas, J.; Scheurer, C.; Scorneaux, B.; Tang, Y.; Urwyler, H.; Wittlin, S.; Charman, W.N. Identification of An Antimalarial Synthetic Trioxolane Drug Development Candidate.  Nature 430, pp. 900–904. 2004
  2. Dong, Y.; Chollet, J.: Matile, H.; Charman, S.A.; Chiu, F.C.K.; Charman, W.N.; Scorneaux, B.; Urwyler, H.; Santo Thomas, J.; Scheurer, C.; Snyder, C.; Dorn, A.; Wang, X.; Karle, J.M.; Tang, Y.; Wittlin, S.; Brun, R.; Vennerstrom, J.L.; Spiro and Dispiro-Prototypes. J. Med. Chem., 48, pp. 4953-4961. 2005
  3. Wang, X.; Dong, Y.; Wittlin, S.; Creek, D.; Chollet, J.; Charman, S.A.; Tomas, J.S.; Scheurer, C.; Snyder, C.; Vennerstrom, J.L.; Spiro and Dispiro-1,2-dioxolanes: Contribution of Iron(II)-Mediated One-Electron vs Two-Electron Reduction to the Activity of Antimalarial Peroxides. J. Med. Chem., 50, pp.5840-5847. 2007
  4. Dong, Y.; Wittlin, S.; Sriraghavan, K.; Chollet, J.; Charman, S.A.; Charman, W.N.; Scheurer, C.; Urwyler, H.: Tomas, J.S.; Snyder, C.; Creek, D.J.; Morizzi, J.; Koltun, M.; Matile, H.; Wang, X.; Padmanilayam, M.; Tang, Y,; Dorn, A.; Brun, R.; Vennerstrom, J.L.; The Structure-Activity Relationship of the Antimalarial Ozonide Arterolane (OZ277). J. Med. Chem., 53, pp. 481-491. 2010
  5. Zhao, Q.; Vargas, M.; Dong, Y.; Zhou, L.; Wang, X.; Sriraghavan, K.; Keiser, J.; Vennerstrom, J.L.; Structure-Activity Relationship of an Ozonide Carboxylic Acid (OZ78) against Fasciola hepatica. J. Med. Chem., 53, pp. 4223-4233. 2010
  6. Nuss, J.E.; Dong, Y.; Wanner, L.M.; Ruthel, G.; Wipf, P.; Gussio, R.; Vennerstrom, J.L.; Bavari, S.; Burnett, J.C.; Pharmacophore Refinement Guides the Design of Nanomolar-Rang Botulinum Neurotoxin Serotype A Light Chain Inhibitors. ACS Med. Chem. Lett., 1, pp. 301-305. 2010
  7. Charman, S.A.; Arbe-Barnes, S.; Bathurst, I.C.; Brun, R.; Campbell, M.; Charman, W.N.; Chiu, F.C.K.; Chollet, J.; Craft, J.C.; Creek, D.J.; Dong, Y.; Matile, H.; Maurer, M.; Morizzi, J.; Nguyen, T.; Papastogiannidis, P.; Scheurer, C.; Shackleford, D.M.; Sriraghavan, K.; Stingelin, L.; Tang, Y.; Urwyler, H.; Wang, X.; White, K.L.; Wittlin, S.; Zhou, L.; Vennerstrom, J.L.; Synthetic Ozonide drug Candidate (OZ439) Offers New Hope for a Single-dose Cure of Uncomplicated Malaria. PNAS, 108, pp. 4400-4405. 2011