Jered Garrison, Ph.D.

Assistant Professor

Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
985830 Nebraska Medical Center
Omaha, NE 68198-5830
402-559-3453 (Office)
402-559-6421 (Lab)
402-559-9365 (Fax)
jcgarrison@unmc.edu
http://cddn.unmc.edu

Teaching Activities:
Introduction to Pharmaceutical Sciences PHSC 550
Pharmaceutical Sciences PHSC 570
Medicinal Chemistry I PHSC 626
Medicinal Chemistry II PHSC 628
Pharmaceutical Science Applications in Pharmacy PHSC 691
Quantitative Pharmaceutical Sciences (X-ray crystallography) PHSC 845
Current Topics in the Pharmaceutical Sciences PHSC 960
Seminar in Pharmaceutical Sciences PHSC 970

Research Activities/Interests:  
Dr. Garrison’s primary interest is in targeted molecular imaging and radiotherapeutic agent design; development of cancer-specific prodrugs; and polymer based drug delivery systems. His laboratory is currently working on the development and evaluation of cleavable linkers for enhanced diagnostic imaging and radiotherapy as well as the design of hypoxia enhanced bombesin analogs for the staging and treatment of prostate cancer. Dr. Garrison’s laboratory performs peptide synthesis and small molecule X-ray crystallography services for investigators both on and off the UNMC campus.

Recent Publications:

  1. Zhou Z, Wagh NK, Ogbomo SM, Shi W, Jia Y, Brusnahan SK, Garrison JC. Synthesis and in vitro and in vivo evaluation of hypoxia-enhanced 111in-bombesin conjugates for prostate cancer imaging. J Nucl Med. 2013 Sep;54(9):1605-12. doi:10.2967/jnumed.112.117986. Epub 2013 Jul 29. PubMed PMID: 23896558.
  2. Ogbomo SM, Shi W, Wagh NK, Zhou Z, Brusnahan SK, Garrison JC. 177Lu-labeledHPMA copolymers utilizing cathepsin B and S cleavable linkers: synthesis, characterization and preliminary in vivo investigation in a pancreatic cancer model. Nucl Med Biol. 2013 Jul;40(5):606-17. doi: 10.1016/j.nucmedbio.2013.01.011. Epub 2013 Apr 24. PubMed PMID: 23622691; PubMed Central PMCID: PMC3665621.
  3. Wagh NK, Zhou Z, Ogbomo SM, Shi W, Brusnahan SK, Garrison JC. Development of hypoxia enhanced 111In-labeled Bombesin conjugates: design, synthesis, and in vitro evaluation in PC-3 human prostate cancer. Bioconjug Chem. 2012 Mar 21;23(3):527-37. doi: 10.1021/bc200600w. Epub 2012 Feb 16. PubMed PMID: 22296619;PubMed Central PMCID: PMC3310374.
  4. Abd-Elgaliel WR, Gallazzi F, Garrison JC, Rold TL, Sieckman GL, Figueroa SD,Hoffman TJ, Lever SZ. Design, synthesis, and biological evaluation of an antagonist-bombesin analogue as targeting vector.  Bioconjug Chem. 2008 Oct;19(10):2040-8. doi: 10.1021/bc800290c. Epub 2008 Sep 23. PubMed PMID:18808168; PubMed Central PMCID: PMC2659627.
  5. Garrison JC, Rold TL, Sieckman GL, Naz F, Sublett SV, Figueroa SD, Volkert WA ,Hoffman TJ. Evaluation of the pharmacokinetic effects of various linking group using the 111In-DOTA-X-BBN(7-14)NH2 structural paradigm in a prostate cancer model. Bioconjug Chem. 2008 Sep;19(9):1803-12. doi: 10.1021/bc8001375. Epub 2008 Aug 20. PubMed PMID: 18712899; PubMed Central PMCID: PMC2647743.
  6. Garrison JC, Rold TL, Sieckman GL, Figueroa SD, Volkert WA, Jurisson SS, Hoffman TJ. In vivo evaluation and small-animal PET/CT of a prostate cancer mouse model using 64Cu bombesin analogs: side-by-side comparison of the CB-TE2A and DOTA chelation systems. J Nucl Med. 2007 Aug;48(8):1327-37. Epub 2007 Jul 13.PubMed PMID: 17631556.
  7. Prasanphanich AF, Nanda PK, Rold TL, Ma L, Lewis MR, Garrison JC, Hoffman TJ, Sieckman GL, Figueroa SD, Smith CJ. [64Cu-NOTA-8-Aoc-BBN(7-14)NH2] targeting vector for positron-emission tomography imaging of gastrin-releasing peptide receptor-expressing tissues. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12462-7. Epub 2007 Jul 12. PubMed PMID: 17626788; PubMed Central PMCID: PMC1914305.
  8. Garrison JC, Panzner MJ, Custer PD, Reddy DV, Rinaldi PL, Tessier CA, Youngs WJ. Synthesis and characterization of a trigonal bipyramidal supramolecular cage based upon rhodium and platinum metal centers. Chem Commun (Camb). 2006 Nov;28(44):4644-6. Epub 2006 Sep 29. PubMed PMID: 17082870.
  9. Garrison JC, Youngs WJ. Ag(I) N-heterocyclic carbene complexes: synthesis, structure, and application.
    Chem Rev. 2005 Nov;105(11):3978-4008.Review. PMID: 16277368.
  10. Custer PD, Garrison JC, Tessier CA, Youngs WJ. Anion directed synthesis of paddlane and trisilver tweezer complexes based upon silver coordination chemistry. J Am Chem Soc. 2005 Apr 27;127(16):5738-9. PMID: 15839642.
    

Jered Garrison, Ph.D.
Dr. Garrison
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