Alexander V. Kabanov, Ph.D., Dr.Sc.

Parke-Davis Professor of Pharmaceutical Sciences, Professor of Genetics, Cell Biology and Anatomy and Professor, Eppley Institute for Research in Cancer Director, Center for Drug Delivery and Nanomedicine

KabanovCollege of Pharmacy
University of Nebraska Medical Center
985830 Nebraska Medical Center
Omaha, NE 68198-5830
402-559-9364 (Office)
402-559-9915 (Lab)
402-559-9365 (Fax)
akabanov@unmc.edu

Teaching Activities:
Dr. Kabanov has developed a Web course on physicochemical principles in the pharmaceutical sciences, which is available online for professional and graduate instruction. At the graduate level Dr. Kabanov has initiated and coordinated a new course Polymer Therapeutics. Also, he has lectured in graduate courses on Physical Pharmacy, Quantitative Pharmaceutical Analysis, Innovative Drug Delivery Systems, and Advanced Medicinal Chemistry.

Research Activities/Interests:
Dr. Kabanov's research interests encompass the interface of physical chemistry, life sciences and medicine. Particular emphasis is being placed on the use of polymers in therapeutics as well as fundamental studies on structure and environmentally induced transitions of self-assembled polymer materials. Current research includes the use of polymers for gene therapy, evaluation of block copolymer-based therapeutics to overcome drug resistance in treating cancer as well as improving drug delivery to the brain by inhibiting drug efflux systems. The laboratory is also very active in developing novel classes of environmentally and chemical-stimuli responsive polymer materials on the basis of block ionomer complexes.

Visit Nanomedicine Group webpage for more information.

Recent Publications:

  1. Wang, Y.; Han, P.; Xu, H.; Wang, Z.; Zhang, X.; Kabanov, A.V.; Photocontrolled Self-Assembly and Disassembly of Block Ionomer Complex Vesicles: A Facile Approach Toward Supramolecular Polymer Nanocontainers. Langmuir 26 (2): 709-15, Epub 2009, Jul 24. Times Cited: 15. 2010
  2. Zhao, Y.; Haney, M.J.; Klyachko, N.L.; Li, S.; Booth, S.L.; Higginbotham, S.M.; Jones, J.; Zimmerman, M.C.; Mosley, R.L.; Kabanov, A.V.; Gendelman, H.E.; Batrakova, E.V.; Polyelectrolyte Complex Optimization for Macrophage Delivery of Redox Enzyme Nanoparticles. Nanomedicine (Lond). 6 (1): p. 25-42. 2011
  3. Nukolov, N.V.; Yang, Z.; Kim, J.O.; Kabanov, A.V.; Bronich, T.K.; Polyelectrolyte Nanogels Decorated with Monoclonal Antibody for Targeted Drug Delivery, Reactive & Functional Polymers. 71 (3): p. 315-323. 2011
  4. Tong, J.; Zimmerman, M.C.; Li, S.; Yi, X.; Luxenhofer, R.; Jordan, R.; Kabanov, A.V.; Neuronal Uptake and Intracellular Superoxide Scavenging of a New Fullerene (C60)-poly(2-oxazonline)s nanoformulation. Biomaterials. 32(14): p 3654-3665. Epub 2011, Feb 2011
  5. Batrakova, E.V.; Gendelman, H.E.; Kabanov, A.V.; Cell-mediated Delivery of Nanoformulated Drugs, Exp. Opin. Drug Del. 8(4): p. 415-433. Epub 2011, Feb 24. 2011
  6. Nukolova, N.V.; Oberoi, H.S.; Kabanov, A.V.; Bronich, T.K.; Folate-decorated nanogels for Targeted Therapy of Ovarian Cancer, Biomaterials 2011 Aug; 32(23): P. 5417-5426. May 4 [Epub ahead of print] 2011
  7. Haney, M.J.; Zhao, Y.; Li, S.; Higginbotham, S.M.; Booth, S.L.; Han, H.-Y.; Vetro, J.A.; Mosley, R.L.; Kabanov, A.V.; Gendelman, H.E.; Batrakova, E.V.; Cell-mediated Transfer of Catalase Nanoparticles from Macrophages to Brain Endothelial, Glial and Neuronal Cells: Implications for Nanomedicine Drug Delivery to the Central Nervous System, Nanomedicine (Lond). Mar 31 2011
  8. Luxenhofer, R.; Sahay, G.; Schulz, A.; Alakhova, D.; Bronich, T.K.; Jordan, R.; Kabanov, A.V.; Structure-property Relationship in Cytotoxicity and Cell Uptake of poly(2-oxazonline) amphiphiles, J. Control. Release, April 13, 2011
  9. Banks, W.A.; Gertler, A.; Soloman, G.; Niv-Spector, L.; Yacobovitz, M.; Yi, X.; Batrakova, E.V.; Vinogradov, S.; Kabanov, A.V.; Principles of Strategic Drug Delivery to the Brain (SDDB): Development of Anorectic and Orexigenic Analogs of Leptin. Physiol Behav., June 6, 2011
  10. Oberoi, H.S.; Laquer, F.C.; Marky, L.A.; Kabanov, A.V.; Bronich, T.K.; Core Cross-linked Block Ionomer Micelles as pH-responsive Carriers for cis-diamminedichloroplatinum (II). J Control Release., Apr 8, 2011