Peter F. Kador, Ph.D.

Professor

Department of Pharmaceutical Sciences
College of Pharmacy
University of Nebraska Medical Center
986025 Nebraska Medical Center
Omaha, NE 68198-6025
402-559-9261 (Office)
402-559-9543 (Fax)
pkador@unmc.edu

Teaching Activities:
Dr. Kador lectures on Medicinal Chemistry at both the professional and graduate student level and has elective courses for professional students on ophthalmic drugs and diabetic complications. In addition he lectures at the graduate level on Ophthalmic Research and Ocular Pharmacology.

Research Activities/Interests:
The research activity of Dr. Kador's laboratory is focused on the design and synthesis of multifunctional antioxidants and enzyme inhibitors, the mechanism of action of drugs and the development of agents as they relate to the inhibition of diabetic complications, and age related macular degeneration, cataract development and neurodegeneration including Alzheimer's disease.  He is also investigating basic cellular mechanisms that lead to the initiation of diabetic complications and the development of disease-associated animal models.

Recent Publications:

  1. Kador, P.F.; Randazzo, J.; Blessing, K.; Makita, J.; Yu, K.; Hosoyab, K-I.; Terasaki, T.; Polyol Formation in Cell Lines of Rat Retinal Capillary Pericytes and Endothelial Cells (TR-rPCT and TR-iBRB). J Ocul Pharmacol Ther. 25: pp. 299-308. 2009
  2. Jin, H.; Randazzo, J.; Zhang, P.; Kador, P.F.; Multifunctional Antioxidants for the Treatment of Age-Related Diseases. J Med Chem. 53: pp. 1117-1127. 2010
  3. Kador, P.F.; Hamada, H.; Reinhardt, R.A.; Blessing, K.; Effect of an Aldose Reductase Inhibitor on Alveolar Bone Loss Associated with Periodontitis. Postgraduate Medicine. 122: pp. 138-144. 2010
  4. Obrosova, I.G.; Chung, S.S.M.; Kador, P.F.; Mechanisms and Management of Diabetic Cataract. Diabetes Metab Res Rev. 26 (3): pp. 172-180. 2010
  5. Kador, P.F.; Webb, T.R.; Bras, I.D.; Ketring, K.; Wyman, M.; Topical Aldose Reductase Treatment Ameliorates the Development and Progression of Cataracts in Dogs with Diabetes Mellitus: A Pilot Study. Vet Ophthalmol. 13 (6): pp. 363-368. 2010
  6. Makita, J.; Zhang, P.T.; Hosoya, K-I.; Kador, P.F.; Response of Rate Retinal Capillary Pericytes and Endothelial Cells to Glucose. J Ocul Pharm Ther. 2010[Epub ahead of print]
  7. Obrosova, I.G.; Kador, P.F.; Aldose Reductase/Polyol Inhibitors For Diabetic Retinopathy. Curr Pharm Biotechnol. 2010[Epub ahead of print]
  8. Kador, P.F.; O'Meara, J.D.; Blessing, K.; Reinhardt, R.A.; Efficacy of Structurally=Diverse Aldose Reductase Inhibitors on experimental Periodontitis in Rats. J Periodontology. 2010[Epub ahead of print]
  9. Randazzo, J.; Zhang, P.; Makita, J.; Blessing, K.; Kador, P.F.; Orally Active Multi-Functional Antioxidants Delay Cataract Formation in Streptoxotocin (type 1) Diabetic and Gamma-Irradiated Rats. PLoS One. 26; 6 (4): e18980. 2011
  10. Randazzo, J.; Zhang, Z.; Hoff, M.; Kawada, H.; Sachs, A.; Yuan, Y.; Haider, N.; Kador, P.F.; Orally Active Multi-Functional Antioxidants are Neuroprotective in a Rat model of Light-Induced Retinal Damage. PLoS One. [in press] 2011

Peter Kador, Ph.D.
Dr. Kador