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UNeMed Delivery of Compounds Using Nano- and Micro- Particles for the Treatment of Eye Disorders…………………………………………………………………………...
Technology Fields: Drug Delivery Background The treatment of ocular diseases, especially those of the posterior segment of the eye, is often stalled by the inability to provide sustained, adequate levels of therapeutic agents to the target tissues. In addition, most currently available therapeutic agents, including low molecular weight molecules cannot penetrate well across the membrane barriers in order to reach target tissues within the eye. Using chemical modifications of the drugs and by employing nano- and micro-particle technologies, researchers at the University of Nebraska Medical Center have addressed the problems of tissue penetration as well as sustained delivery, and have developed a system that allows for prolonged target tissue delivery of modified drugs, which are activated within the target tissues. In addition to the enhanced delivery of new therapeutics, current data suggests that this system has the potential of reducing cardiotoxicity and systemic toxicities of therapeutic agents.
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