Vinod Labhasetwar, Ph.D.

 

 

Peer Reviewed Publications

  1. Labhasetwar V, Puranik PK, Dorle AK: Evaluation of shellac-glycerol esters as anhydrous binding agents. Indian J. Pharm. Sci. 50: 343-345,1988. 

  2. Labhasetwar V, Joshi SV, Dorle AK: A study on dielectric constant of microcapsules during aging. J. Microencapsulation 5: 339-341, 1988. 

  3. Narsimhan R, Labhasetwar V, Lakhotia CL, Dorle AK: Timed-release noscapine microcapsules. Indian J. Pharm. Sci. 50: 120-122, 1988.

  4. Labhasetwar V, Puranik PK, Dorle AK: Evaluation of shellac-glycerol esters as microencapsulating materials. J. Microencapsulation 6:115-118, 1989.

  5. Labhasetwar V, Dorle AK: Nanoparticles-A colloidal drug delivery system for primaquine and metronidazole. J. Controlled Release 12:113-119, 1990.

  6. Labhasetwar V, Puranik PK, Dorle AK: Study on shellac-glycerol esters as microencapsulating materials. II Quantitative correlation between physicochemical properties and drug release. J. Microencapsulation 7: 553-554, 1990.

  7. Labhasetwar V, Levy RJ: Implants for site-specific drug delivery. J. Applied Biomaterials 2: 211-212, 1991.

  8. Labhasetwar V, Dorle AK: A study on the zeta potential of microcapsules during aging. J. Microencapsulation 8: 83-85, 1991. 

  9. Labhasetwar V, Levy RJ: Polymer systems for cardiovascular drug delivery. Polymer News 17: 336-342, 1992 (Leading Article). 

  10. Labhasetwar V, Kadish A, Underwood T, Sirinek M, Levy RJ: The efficacy of d-sotalol polyurethane epicardial implants for ventricular arrhythmias due to acute ischemia in dogs. J. Controlled Release 23:75-86, 1993. 

  11. Labhasetwar V, Deshmukh SV, Dorle AK: Studies on some crystalline forms of ibuprofen. Drug Development and Industrial Pharmacy. 19(6): 631-641, 1993.

  12. Pathak YV, Labhasetwar V: Scanning electron microscopy applications in characterizing and evaluating drug delivery systems. Cells & Materials 3(l):51-66, 1993. 

  13. Labhasetwar V, Underwood T, Gallagher M, Murphy G, Langberg J, Levy RJ: Sotalol controlled release systems for arrhythmias: in vitro characterization, invivo drug disposition, and electrophysiologic effects. J. Pharm. Sci. 83 (2): 156-164, 1994. 

  14. Choudhari KB, Labhasetwar V, Dorle AK: Liposomes as carrier for oral administration of insulin: effect of formulation factors. J. Microencapsulation 11 (3):319-325, 1994. 

  15. Labhasetwar V, Dorle AK: Dielectric constant during emulsification. Drug Development and Industrial Pharmacy 20 (13): 2135-2141, 1994. 

  16. Schwendeman SP, Amidon GL, Labhasetwar V, Levy RJ: Modulated drug release using iontophoresis through heterogeneous cation-exchange membranes II. influence of cation-exchanger content on membrane resistance and characteristic times. J. Pharm. Sci. 83: 1282-1294, 1994. 

  17. Labhasetwar V, Underwood T, Gallagher M, Langberg J, Levy RJ: Epicardial controlled release ibutilide: Effects on defibrillation threshold and electrophysiologic parameters. J. Cardiov. Pharmacol. 24: 826-840, 1994. 

  18. Labhasetwar V, Mohan MS, Dorle AK: A study on zeta potential and dielectric constant of liposomes. J. Microencapsulation 11, 663-668, 1994. 

  19. Labhasetwar V, Underwood T, Schwendeman S, Levy RJ: Iontophoresis for modulation of cardiac drug delivery. Proc. Natl. Acad. Sci. USA 92, 2612-2616, 1995. 

  20. Villa AE, Guzman LA, Poptic EJ, Labhasetwar V, D'Souza S, Farrel CL, Plow EF, Levy RJ, DiCorleto P, Topol, EJ: The effects of antisense c-myb oligonucleotides on vascular cell proliferation and response to vessel wall injury. Cir. Res. 76, 505-513, 1995. 

  21. Schwendeman S, Labhasetwar V, Levy RJ: Model features of a cardiac iontophoretic drug deliver implant. Pharm. Res. 12, 790-795, 1995. 

  22. Labhasetwar V, Levy RJ: Novel delivery of antiarrhythmic agents. Clinical Pharmacokinetics 29, 1-5, 1995 (Leading Article). 

  23. Levy RJ, Labhasetwar V, Song C, Lerner E, Chen W, Vyavahare N, Qu X: Polymeric drug delivery systems for treatment of cardiovascular calcification, arrhythmias, and restenosis. J. Controlled Release 36, 137-147, 1995. 

  24. Levy RJ, Labhasetwar V, Strickberger SA, Underwood T, Davis J: Controlled release implant dosage forms for cardiac arrhythmias-review and perspectives. Drug Delivery 3,137-142, 1996. 

  25. Guzman L, Labhasetwar V, Song C, Jang Y, Lincoff AM, Levy RJ, Topol E: Local intraluminal infusion of biodegradable polymeric nanoparticles: a novel approach for prolonged drug delivery after balloon angioplasty. Circulation 94,1441-1448, 1996. 

  26. Desai M, Labhasetwar V, Amidon G, Levy RJ: Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm. Res. 13, 1837-1844, 1996. 

  27. Song C, Labhasetwar V, Murphy M, Qu X., Humphrey WR, Shebuski RJ, Levy RJ: Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery. J. Controlled Release 43, 197-212, 1997. 

  28. Song C, Labhasetwar V, Levy RJ: Controlled release of U-86983 from double layer PLGA films: Effect of additives on release rates and kinetics. J. Controlled Release 45, 177-192, 1997.

  29. Labhasetwar V, Chen B, Muller D, Bonadio J, Ciftci K, March K, Levy RJ: Gene-based therapies for restenosis. Adv. Drug Del. Rev. 24, 109-120, 1997. 

  30. Labhasetwar V, Song C, Levy RJ: Nanoparticles drug delivery system in restenosis. Adv. Drug Del. Rev. 24, 63-85, 1997. 

  31. Humphrey R, Erickson L, Simmons C, Northrup J, Wishka D, Morris J, Labhasetwar V, Song C, Levy RJ, Shebuski RJ: The effect of intramural delivery of polymeric nanoparticles loaded with the antiproliferative 2-aminochromone U-86983 on neointimal hyperplasia development in balloon­ injured porcine coronary arteries. Adv. Drug Del. Rev. 24, 87-108, 1997. 

  32. Gottsauner-Wolf M, Jang Y, Lincoff AM, Cohen JL, Labhasetwar V, Poptik EJ, Forudi F, Guzman L, DiCorletto PE, Levy RJ, Topol EJ, Ellis SG: Influence of local delivery of the protein tyrosine kinase receptor inhibitor tyrphostin-47 on smooth muscle cell proliferation in the rat carotid balloon injury model. American Heart J. 133 (3), 329-334, 1997. 

  33. Desai M, Labhasetwar V, Walter E, Levy RJ, Amidon G: Mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. Pharm. Res. 11, 1568-1573, 1997.

  34. Labhasetwar V, Strickberger A, Davis J, Underwood T, Levy RJ: Prevention of acute inducible atrial flutter in dogs using an ibutilide-polymer coated pacing electrode. J. Cardiov. Pharmacol. 31, 449­455, 1998. 

  35. Song C, Labhasetwar V, Xiumin C, Underwood T, Levy RJ: Arterial uptake of biodegradable nanoparticles for intravascular local drug delivery: results in an acute dog model. J. Controlled Release 54, 201-211, 1998.  

  36. Labhasetwar V, Song C, Humphrey W, Chen B, Muller DMW, Shebuski RJ, Levy RJ: Arterial uptake of biodegradable nanoparticles: effect of surface modifications. J. Pharm. Sci. 87, 1229-1234, 1998. 

  37. Labhasetwar V, Bonadio J, Goldstein S, Chen W, Levy RJ: A DNA controlled release coating for gene transfer: transfection in skeletal and cardiac muscles. J. Pharm. Sci. 87, 1347-1350, 1998.

  38. Song C, Sun H, Yang J, Wang P, Labhasetwar V, Levy, R: Synthesis of biodegradable and functional block copolymers for protein delivery, Proceedings of the 20th Annual International Conference of the IEEE. 6, 2897-2900, 1998. 

  39. Labhasetwar V, Bonadio J, Goldstein S, Levy RJ: Gene trasfection using biodegradable nanospheres: results in tissue culture and a rat osteotomy model. Colloids and Surfaces B: Biointerfaces 16, 281-290, 1999. 

  40. Desai M, Hilfinger J, Amidon G, Levy RJ, Labhasetwar V: Immune response with biodegradable nanospheres and alum: studies in rabbits using staphylococcal entertoxin B-toxoid. J. Microencapsulation 17, 215-225, 2000.

  41. Zhou W and Labhasetwar V: Transfection of Caco-2 cells by PLGA-nanoparticles.  Polymer Preprints 2000, 41, 1635-1636, 2000. 

  42. Raghuvanshi R, Misra A, Talwar GP, Levy RJ, Labhasetwar V: Enhanced immune response with a combination of alum and biodegradable nanoparticles containing tetanus toxoid. J. Microencapsulation 18, 723-732, 2001. 

  43. Davda J and Labhasetwar V: An update on angiogenesis therapy. Critical Reviews in Eukaryotic Gene Expression 11, 1-21, 2001. (Invited Review)

  44. Davda J and Labhasetwar V. Characterization of nanoparticle uptake by endothelial cells, Int. J. Pharm. 233, 51-59, 2002.  (Drug Discovery Gateway featured article, Feb 5, 2004)

  45. Sahoo S, Panyam J, Prabha S, Labhasetwar V. Residual polyvinyl alcohol associated with poly (D,L lactide-co-glycolide) nanoparticles affects their physical and cellular uptake properties, J. Controlled Release, 82,105-114, 2002.  

  46. Panyam J, Zhou WZ, Prabha S, Sahoo S, Labhasetwar V. Rapid endo-lysomal escape of poly (D, L-lactide-co-glycolide) nanoparticles: implication for drug and gene delivery. FASEB J. 16, 1217-1226, 2002.   (Listed on NCI web site under NCI Alliance for Nanotechnology in Cancer)

  47. Panyam J, Lof J, O’Leary E, Labhasetwar V, Efficiency of DispatchÒ and InfiltratorÒ cardiac infusion catheters in arterial localization of nanoparticles in a porcine coronary model of restenosis, J. Drug Targeting, 10(6), 517-523.

  48. Prabha S, Zhou WZ, Panyam J, Labhasetwar V. Size-dependency of nanoparticle-mediated gene transfection: Studies with fractionated nanoparticles. Int. J. Pharm. 244 (1-2), 105-115, 2002. 

  49. Panyam, J. and Labhasetwar, V. Dynamics of endocytosis and exocytosis of poly (DL-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells. Pharm Res, 20(2), 210-218, 2003.

  50. Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue, Adv. Drug Del. Rev. 55, 329-347, 2003. (Invited Review, Listed as top-six most popular ScienceDirect articles in Pharmaceutical Sciences in 2003, ScienceDirect Listed as Top 4th article published in Adv. Drug Del. Rev.)

  51. Panyam J, Sahoo S, Prabha S,  Labhasetwar V. Fluorescence and electron microscopy probes for cellular and tissue uptake of poly (D, L-lactide-co-glycolide) nanoparticles, Int. J. Pharm. 262, 1-11, 2003.

  52. Panyam J, Dali M, Sahoo S, Ma W, Chakravarthi S, Amidon G, Levy RJ, Labhasetwar V. Polymer degradation and in vitro release of a model protein from poly(D,L-lactide-co-glycolide) nano- and microparticles. J. Control. Rel. 92, 173-187, 2003.

  53. Qaddoumi MG, Gukasyan HJ, Davda J, Labhasetwar V, Kim KJ, Lee VHL. Clathrin and caveolin-1 expression in primary pigmented rabbit conjunctival epithelial cells: Role in PLGA nanoparticle endocytosis, Molecular Vision 9,559-568, 2003.

  54. Sahoo S, Labhasetwar V. Nanotech approaches to drug delivery and imaging. Drug Discovery Today 8, 1112-1120, 2003. (Invited Review, Listed as top-three most down loaded article by Drug Discovery during Sept 2003 to Sept 2004)

  55. Prabha S, Labhasetwar V. Critical determinants in PLGA/PLA nanoparticle-mediated gene delivery, Pharm. Res. 21, 354-364, 2004. (Listed on NCI web site under NCI Alliance for Nanotechnology in Cancer)

  56. Panyam J, and Labhasetwar V. Sustained Cytoplasmic Delivery of Drugs with Intracellular Receptors Using Biodegradable Nanoparticles, Molecular Pharmaceutics 1,1,77-84, 2004. (Featured in Modern Drug Discovery, March 2004)

  57. Satturwar PM, Fulzele SV, Panyam J, Mandaogade PM, Mundhada DR, Gogate BB, Labhasetwar V, Dorle AK. Synthesis and evaluation of rosin derivatives for pharmaceutical coating. Int. J. Pharm. 270(1-2), 27-36, 2004.

  58. Qaddoumi MG, Hideo Ueda, Johnny Yang, Davda J, Labhasetwar V, Lee VHL. The characteristics and mechanisms of uptake of PLGA nanoparticles in rabbit conjunctival epithelial cell layers, Pharm. Res. 21, 641-648, 2004. (Featured on the cover page of the issue)

  59. Ma W, Yu H, Wang Q, Jin H, Solheim J, Labhasetwar V. A novel approach for cancer immunotherapy: tumor cells with anchored superantigen SEA generate effective antitumor immunity, J. Clin. Immunology 24, 294-301, 2004.

  60. Panyam J, Labhasetwar V. Targeting intracellular targets, Current Drug Delivery 1 (3), 235-247, 2004. (Invited Review)

  61. Panyam J, Williams D, Dash A, Leslie-Pelecky D, Labhasetwar V: Solid-state solubility of drug in PLGA/PLA polymers influences encapsulation and release of hydrophobic drugs from nanoparticles. J. Pharm. Sci. 93, 1804-1814, 2004.

  62. Prabha S, Labhasetwar V: Nanoparticle-mediated wt-p53 gene delivery results in sustained antiproliferative activity in breast cancer cells, Mol. Pharm. 1(3), 211-219, 2004. (Featured in Chemical & Engineering News in May 2004 under Nanofocus)

  63. Sahoo SK, Ma W, Labhasetwar V. Efficacy of transferrin-conjugated paclitaxel-loaded nanoparticles in a murine model of prostate cancer.  Int. J. Cancer Res. 112, 335-340, 2004. (Listed on NCI web site under NCI Alliance for Nanotechnology in Cancer)

  64. Sahoo SK, Panda AK, Labhasetwar V. Characterization of porous PLGA/PLA microparticles as a scaffold for three dimensional growth of breast cancer cells. Biomacromolecules, 6, 1132-1139, 2005.

  65. Davda J, Labhasetwar V. Sustained activity of vascular endothelial growth factor following encapsulation in nanoparticles. J. Biomed. Nanotechnology. 1,74-82, 2005. (Invited article for the inaugural issue)

  66. Vasir JK, Reddy MK, Labhasetwar V. Nanosystems in drug targeting: opportunities and challenges. Current Nanoscience, 1(1), 45-62, 2005. (Invited review for the inaugural issue)

  67. Morales MA, Jain TK, Labhasetwar V, Leslie-Pelecky DL. Magnetic studies of iron oxide nanoparticles coated with oleic acid and Pluronic® block copolymer. J. Appl. Phys., 97 (10Q901), 1-3, 2005.

  68. Jain TK, Morales MA, Sahoo SK, Leslie-Pelecky DL, Labhasetwar V. Ion-oxide nanoparticles for sustained delivery of anticancer agents. Mol. Pharm., 2, 194-205, 2005.

  69. Sahoo SK, Labhasetwar V. Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention. Mol. Pharm., 2, 373-383, 2005.

  70. Vasir JK, Labhasetwar V. Targeted drug delivery in cancer therapy. Technology in Cancer Research and Treatment. 4, 363-374, 2005.

  71. Labhasetwar V. Nanotechnology for Drug/Gene Therapy: the importance of understanding molecular mechanisms of delivery, Current Opinion in Biotechnology, 16:674–680, 2005.

  72. Labhasetwar V. What is next for nanotechnology, Editorial, Journal of Biomedical Nanotechnology, 1, 373-374, 2005

  73. Vasir JK, Labhasetwar V. Polymeric nanoparticles for gene delivery, Expert Opinion on Drug Delivery, 2006 May;3(3):325-344.
     

Book Chapters 

  1. Labhasetwar V: Rectal administration of drugs. Pharmagazine 25, 1984.

  2. Labhasetwar V: Immunoassays and application of monoclonal antibodies. Marine and Human Monoclonal Antibodies: Production, Purification, and Applications: Practical Manual, 1989.

  3. Qadri A, Labhasetwar V: Enzyme immunoassay for diagnosis of typhoid fever, In "A Handbook of Practical and Clinical Immunology", Ed. G.P. Talwar and S. K. Gupta, Publisher CBS Publishers & Distributors, New Delhi, 1992.

  4. Levy RJ, Golomb G, Trachy J, Labhasetwar V, Muller D, Topol E: Strategies for treating arterial restenosis using polymeric controlled release implants, In "Biotechnology and Bioactive Polymers", Ed. Gebelein C and Carraher C, Publisher, Plenum Press, New York, 259-268, 1994.

  5. Chen W, Schwendeman S, Labhasetwar V, Levy RJ: Techniques for cardiovascular drug delivery, In "Polymer Site-Specific Pharmacotherapy", Ed. Domb AJ, Publisher, John Wiley & Sons Ltd., 221-241, 1994.

  6. Labhasetwar V, Schwendeman S, Nguyen T, Underwood T, Levy RJ: Iontophoresis for modulating cardiac drug delivery of antiarrhythmic agents, In" Molecular Interventions and Local Drug Delivery in Cardiovascular Disease", Ed. Edelman ER and Levy RJ, Publisher, W.B. Saunders Company Limited, London, UK, 383-398,1995.

  7. Bolling S, Labhasetwar V, Levy RJ: Local immunosuppression of organ transplant, In "Local Immunosuppression of Organ Transplant", Ed, Gruber Scott A, Publisher, R.G. Landes Company, Austin Texas, USA, 161-167, 1996.

  8. Labhasetwar V: Nanoparticles for drug delivery. Pharmaceutical News 4, 28-31, 1997.

  9. Labhasetwar V: Sustained release gene delivery systems: principles and perspectives, In, "Self­ Assembling Complexes for Gene Delivery: From Laboratory to Clinical Trials", Eds. Kabanov,Seymour, Flegner, Publisher, John Wiley & Son, Ltd, UK, 387-399, 1998.

  10. Davda J, De S, Zhou W, Labhasetwar V: Biodegradable nanospheres: therapeutic applications, in “Frontiers in Biomedical and Polymer Science”, (Ed. E. Chiellini), Kluwer-Plenum Publisher, New York, NY,19-33, 2001.

  11. Prabha S, Ma W, Labhasetwar V: Biodegradable nanoparticles as a gene expression vector, in “Polymeric Gene Delivery: Principles and Applications”, (Ed. M. Amiji), CRC Press 357-365, 2004.

  12. Rao K, Panda AK, Labhasetwar V: Intravascular drug delivery systems and devices: interactions at biointerface, in “Surfaces and Interfaces for Biomaterials”, (Ed. Pankaj Vadgama), Woodhead Publishing Limited, Abington, UK. 573-584, 2005.

  13. Leslie-Pelecky D, Labhasetwar V, Kraus Jr. RH: Biomagnetics, in “Advanced Magnetic Nanostructures”, (Eds. D. Sellmyer and R. Skomski), Springer, New York, NY, 461-482, 2006.

  14. Sahoo S, Labhasetwar V: Nanoparticle Interface: An Important determinant in nanoparticle-mediated drug/gene delivery, in "Nanoparticle Technology for Drug Delivery", (Eds. Gupta and Kompella), Mercel Dekker, Inc. New York, NY, 139-160, 2006.

  15. Sahoo S, Jain T, Reddy M, Labhasetwar V: Nano-sized carriers for drug delivery, in "Nanobiotechnology", (Ed. Elan Levy), The Humana Press Inc., Totowa, NJ, 2006 (in press).

  16. Vasir J, Labhasetwar V: Biodegradable nanoparticles, in "DNA Delivery/Gene Transfer Vector Lab Manual", (Eds. Friedmann and Rossi), Cold Spring Harbor Laboratory Press, Woodbury Genome Center, Woodbury, NY, 2006 (in press).

  17. Vasir J, Labhasetwar V: Nanoparticles for Gene Delivery: Formulation Characteristics, in “Nanoparticulate Drug Delivery Systems: Recent Trends and Emerging Technologies”, (Eds Thassu, Deleers, Pathak), CRS Press, 2006 (in press).

 

MinI-REPORT

  1. Labhasetwar V: 29th Controlled Release Society Annual Meeting: Excelling the Science of Drug Delivery, New Drugs, July 20-25, 2002.

Abstracts and Preliminary Communications  

  1. Labhasetwar V, Dorle AK. Electrokinetic potential of erythrocytes in alloxan induced diabetic rabbit, 38th Indian Pharmaceutical Congress, Ahamadabad, India, 1986.

  2. Labhasetwar V, Dorle AK. Nanoparticles-A new colloidal drug delivery system for primaquine and metronidazole, 6th International Symposium on Microencapsulation, Dubrovnik,Yugoslavia, 1987.

  3. Labhasetwar V, Dorle AK. Electrokinetic potential of erythrocytes in cardiac disorders, International Conference on Biomembranes in Health and Diseases, Lucknow, India, 1988.

  4. Labhasetwar V, Choudhari KB, Dorle AK. Oral administration of insulin. International Conference on Biomembranes in Health and Diseases, Lucknow, India, 1988.

  5. Labhasetwar V, Dorle AK. Electrokinetic potential of erythrocytes in acute renal failure, 39th Indian Pharmaceutical Congress, Madras, India, 1988.

  6. Reddy P, Labhasetwar V, Dorle AK. Study on albumin microspheres as a carrier for drugs, 39th Indian Pharmaceutical Congress, Madras, India, 1988.

  7. Labhasetwar V, Dorle AK: A study on the process of emulsification through dielectric constant, 41st Indian Pharmaceutical Congress, Bombay, India, 1989.

  8. Labhasetwar V, Qadri A, Ghosh S, Talwar GP. Dipstick Dot-EIA for the diagnosis of typhoid and drug sensitivity test, Indian Immunological Society, Wardha, India, 1989.

  9. Labhasetwar V, Kadish A, Underwood T, Sirinek M, Levy RJ. Epicardial d-sotalol prevents ischemia-induced ventricular arrhythmias in dogs, Twenty First Annual Cardiovascular Research Forum, Ann Arbor, MI, 1991.

  10. Labhasetwar V, Kadish A, Underwood T, Sirinek M, Levy RJ. Controlled release matrix system for epicardial. delivery of d-sotalol in ischemia induced ventricular arrhythmias in dog. American Association of Pharmaceutical Scientists, Washington D.C., 1991.

  11. Levy RJ, Langberg J, Labhasetwar V, Underwood T, Gallagher M. Controlled release from polymer matrices for cardiac arrhythmias. Proceeding, Cardiovascular Science & Technology Conference, Bethesda, Maryland, 1991.

  12. Siden R, Labhasetwar V, Levy RJ. Epicardial antiarrhythmic drugs for the prevention of ventricular arrhythmias, American Society of Hospital Pharmacist, 1991.

  13. Levy RJ, Golomb G, Labhasetwar V: New frontiers in cardiovascular polymeric controlled release. 203rd American Chemical Society, San Francisco, 1992.

  14. Labhasetwar V, Underwood T, Gallagher M, Langberg J, Levy RJ. dl-Sotalol polymeric controlled release preparations: in vitro Characterization, in vivo drug disposition, and electrophysiologic effects. Proceed. 19th International Symposium on Controlled Release of Bioactive Materials, Orlando, FL, 1992.

  15. Schwendeman SP, Amidon GL, Labhasetwar V, Levy RJ. Modulated release of d-sotalol using iontophoresis through heterogeneous cation-exchange membranes. Proceed. 19th International Symposium on Controlled Release of Bioactive Materials, Orlando, FL, 1992.

  16. Labhasetwar V, Schwendeman S, Levy RJ. Novel polymeric systems for antiarrhythmic controlled release implants. Department of Pediatrics Cardiology Annual Research Symposium, Ann Arbor, MI, 1992.

  17. Labhasetwar V, Kadish A, Underwood T, Sirinek M, Levy RJ. Epicardial d-sotalol prevents ischemia-induced ventricular arrhythmias in dogs. American Heart Association Scientific Sessions, New Orleans, LA, 1992.

  18. Schwendeman SP, Labhasetwar V, Levy RJ. Controlled release drug delivery implants for cardiac arrhythmias: iontophoresis modulation. The Cardiovascular Science and Technology Conference, Bethesda, Maryland, 1992.

  19. Langberg J, Underwood T, Gallagher M, Labhasetwar V, and Levy RJ. The Effect of ibutilide applied to the epicardium on defibrillation threshold. American College of Cardiology, 42nd Annual Scientific Session, Anaheim, California, 1993.

  20. Labhasetwar V, Schwendeman SP, Underwood T, Gallagher M, Nguyen T, Langberg J, Levy RJ. Epicardial iontophoretic delivery of antiarrhythmic agents. 20th International Symposium on Controlled Release of Bioactive Materials, Washington, D.C., 1993.

  21. Labhasetwar V, Schwendeman S, Underwood T, Gallagher M, Nguyen T, Langberg J, Levy RJ. lontophoretic modulation of antiarrhythmic agents to heart. American Heart Association of Michigan, E. Lansing, MI 1993.

  22. Labhasetwar V, Underwood T, Nguyen T, Levy RJ. Implantable iontophoretic device for modulated delivery of antiarrhythmic agents. Department of Pediatrics Annual Research Symposium, Ann Arbor, MI 1993.

  23. Villa AE, Guzman LA, Poptic E, Labhasetwar V, DeSouza S, Plow E, Levy RJ, DiCorleto P, Topol EJ. Local delivery of antisense c-myb for prevention of neointimal proliferation after balloon arterial injury. American Heart Association, 66th Scientific Sessions, Atlanta, Georgia 1993.

  24. Apuri B, Labhasetwar V, Brooks R, Robinson N, Goldberg J, Levy R, Kadish A. Effects of epicardial sotalol in a canine myocardial infarct model. American College of Cardiology, 43rd Annual Scientific Sessions, 1994.

  25. Labhasetwar V, Underwood T, Levy RJ. Cardiac iontophoretic implant for antiarrhythmic agents. Proceed. 21st International Symposium on Controlled Release of Bioactive Materials, June 24-30, Nice, France, 1994.

  26. Labhasetwar V, Underwood T, Levy RJ. Iontophoretic modulation for epicardial administration of antiarrhythmic agents in chronic implant. American Heart Association of Michigan, Ann Arbor, September 20, 1994.

  27. Labhasetwar V, Underwood T, Schwendeman SP, Levy RJ. Ion-selective membranes for iontophoretic regulation of epicardial delivery kinetics of antiarrhythmic agents. Department of Pediatrics, Annual Research Symposium, Ann Arbor, MI, September 23, 1994.

  28. Guzman LA, Labhasetwar V, Song C, Jang Y, Levy RJ. Local intraluminal infusion of biodegradable polymeric nanoparticles: A novel approach for prolonged drug delivery after balloon angioplasty. American Heart Association, 67th Scientific Sessions, Dallas, Texas, November 14-17, 1994.

  29. Labhasetwar V, Underwood T, Schwendeman S, Levy RJ. lontophoresis for modulation of cardiac drug delivery. ASAIO Cardiovascular Science and Technology Conference, Washington, DC, December 9-11, 1994.

  30. Humphrey W, Simmons C, Northrup JL, Wishka DG, Morris J. Labhasetwar V, Song C, Levy RJ, Shebuski RJ. Site-specific delivery of polymeric nanoparticles (PNP) loaded with the 2-aminochromone U-86983 can retard intimal hyperplasia in balloon porcine coronary arteries. Experimental Biology 95.

  31. Labhasetwar V, Song C, Guzman L, Topol E, Humphrey W, Shebuski RJ, Levy RJ. Formulation and evaluation of nanoparticles for intra-arterial localization in restenosis. Restenosis Summit VTI, Cleveland, OH, May 18-19,1995.

  32. Guzman L, Labhasetwar V, Song C, Jang Y, Levy RJ, Topol E. Local intraluminal infusion of biodegradable polymeric nanoparticles matrixed with dexamethasone: a novel antiproliferative approach for prolonged drug delivery after balloon angioplasty. Restenosis Summit VII, Cleveland, OH, May 18-19,1995.

  33. Villa AE, Guzman LA, Poptic EJ, Labhasetwar V, D'Souza S, Farrel CL, Plow EF, Levy RJ, DiCorleto P,' Topol, EJ. The effects of antisense c-myb oligonucleotides on vascular cell proliferation and response to vessel wall injury. Restenosis Summit VH, Cleveland, OH, May 18-19, 1995.

  34. Labhasetwar V, Song C, Humphrey W, Shebuski RJ, Levy RJ. Nanoparticles for site specific delivery of U-86983 in restenosis in pig coronary arteries. Proceed. 22nd Intern. Symp. Control. Rel. Bioact. Mater. Seattle, WA, July 30-August 2, 1995.

  35. Song C, Labhasetwar V, Guzman L, Topol E, Levy RJ. Dexamethasone-nanoparticles for intraarterial localization in restenosis in rats. Proceed. 22nd Intern. Symp. Control. Rel. Bioact. Mater. Seattle, WA, July 30-August 2, 1995. 

  36. Guzman L, Labhasetwar V, Song C, Jang Y, Levy RJ, Topol E. Local intraluminal infusion of biodegradable polymeric nanoparticles matrixed with dexamethasone: a novel antiproliferative approach for prolonged drug delivery after balloon angioplasty. European Heart Society Meeting, August 1995.

  37. Desai M, Labhasetwar V, Song C, Qu X, Amidon G, Levy RJ. Uptake of microparticles by gut associated lymphoid tissue. American Association of Pharmaceutical Scientists, Miami, FL, November 5-9, 1995.

  38. Labhasetwar V, Underwood T, Davis J, Song C, Levy RJ. Cardiac implant for modulated drug delivery. Department of Pediatric Annual Research Symposium, MI, September 29, 1995.

  39. Levy RJ and Labhasetwar V. Cardiac controlled release implants for arrhythmias: sustained release and iontophoretic modulation. The First Annual International Symposium on Local Cardiovascular Drug Delivery. Cambridge, MA, September 28-29,1995.

  40. Charapata CM, Labhasetwar V, Levy RJ. Iontophoretic delivery of Class III antiarrhythmic agents using a heterogeneous cation-exchange membrane (HCM). The 25th Annual Cardiovascular Research Forum, American Heart Association, MI, Rochester, MI, September 29, 1995.

  41. Ecclestone DS, Furst J, Labhasetwar V, Levy RJ, Lincoff AM. Local delivery of polymeric nanospheres containing heparin reduces platelet deposition in the porcine balloon injury model. American Heart Association 68th Scientific Sessions, Anaheim, CA, November 13-16, 1995.

  42. Guzman L, Labhasetwar V, Song C, Jang Y, Lincoff AM, Levy RJ. Single intralurninal infusion of biodegradable polymeric nanoparticles matrixed with dexamethasone decreases neointimal formation after vascular injury. American Heart Association 68th Scientific Sessions, Anaheim, CA, November 13-16,1995.

  43. Strickberger SA, Labhasetwar V, Davis J, Underwood T, Levy RJ. Prevention of atrial flutter with epicardial artilide. American College of Cardiology 45th Annual Scientific Session, Orlando, FL, March 25- 29, 1996.

  44. Strickberger SA, Labhasetwar V, Davis J, Underwood T, Levy RJ. Reduced defibrillation threshold with endocardial administration of artilide. American College of Cardiology 45th Annual Scientific Session, Orlando, FL, March 25- 29, 1996.

  45. Song CX, Labhasetwar V, Davis J, Underwood T, Levy RJ. Intra-arterial retention of biodegradable nanoparticles: effect of surface modifications and drug delivery characteristics in acute dog study. Restenosis Summit VIII, Cleveland, OH, May 17-18, 1996.

  46. Levy RJ, Song CX, Labhasetwar V, Davis J, Underwood T. The effect of nanoparticle surface modification on arterial retention post angioplasty in a dog femoral artery model. 23rd Intern. Symp. Control. Rel. Bioact. Mater. Kyoto, Japan, July 7-July 11, 1996.

  47. Song CX, Labhasetwar V, Levy RJ. Modulation of release rates from double-layer poly(lactic-co glycolic acid) films for periadventitial implants in restenosis. 23rd Intern. Symp. Control. Rel. Bioact. Mater. Kyoto, Japan, July 7-July 11, 1996.

  48. Labhasetwar V, Underwood T, Davis J, Strickberger SA, Levy RJ. Controlled drug release pacing electrode system for prevention of postoperative atrial flutter. 23rd Intern. Symp. Control. Rel. Bioact. Mater. Kyoto, Japan, July 7- 11, 1996.

  49. Levy RJ and Labhasetwar V. Cardiac controlled release implants for arrhythmias. 3rd Jerusalem Conference on Pharmaceutical Sciences and Clinical Pharmacology, Jerusalem, Israel, September 1-6,1996.

  50. Labhasetwar V, Underwood T, Davis J, Kurth 1, Levy RJ. Cardiac implant for modulated drug delivery of ibutilide: acute dog results. American Heart Association, MI, E. Lansing, MI, September 6,1996.

  51. Labhasetwar V, Bonadio J, Goldstein S, Muller D, Chen B, Smiley E, Falik R, Levy RJ. Biodegradable nanoparticles: A novel nonviral carrier system for gene delivery. Department of Pediatrics Annual Research Symposium, University of Michigan, Ann Arbor, MI, September 13, 1996.

  52. Bonadio J, Smiley E, Goldstein SA, Ciftci K, Labhasetwar V, Levy RJ. Direct gene transfer in vivo using GAM technology. Gene Therapy, Cold Spring Harbor, New York, September 29, 1996.

  53. Desai M, Labhasetwar V, Walter E, Levy RJ, Amidon G. Comparative uptake of biodegradable microparticles in vitro by caco-2 cells and in situ by rat intestine. American Association of Pharmaceutical Scientist, Seattle, WA, October 28-31, 1996.

  54. Desai M, Labhasetwar V, Hilfinger J, Tsume Y, Amidon G, Levy RJ. Rabbit as a model for oral immunization using enteric capsule. American Association of Pharmaceutical Scientist, Seattle, WA, October 28-31, 1996.

  55. Ciftci K, Smiley E, Labhasetwar V, Bonadio J, Levy RJ.  Effect of lysosomotropic agents on gene expression in vitro. American Association of Pharmaceutical Scientist, Seattle, WA, October 28-3 1, 1996.

  56. Panek R, Chen W, Labhasetwar V, Hamby J, Levy RJ, Uprichard A, Keiser J. Prolonged vascular effects with drug loaded nanoparticles. 24th Intern. Symp. Control. Rel. Bioact. Mater. Stockholm, Sweden, June 15-19, 1997.

  57. Levy RJ, Labhasetwar V, Underwood R, Song C, Chen W. Arterial administration of nanoparticles for restenosis. 24th Intern. Symp. Control. Rel. Bioact. Mater. Stockholm, Sweden, June 15-19, 1997.

  58. Song C, Labhasetwar V, Levy RJ. Synthesis of novel polycaprolactones. 24th Intern. Symp. Control. Rel. Bioact. Mater. Stockholm, Sweden, June 15-19, 1997.

  59. Labhasetwar V. Biodegradable nanospheres for drug delivery applications. Proceed. of 1998 Conference on Pharmaceutical Science and Technology, Fine Particle Society, Dallas, TX, April 1-3, 1998.

  60. Song CX, Wang PY, Levy R, Sun HF, Yang J, Labhasetwar V. Synthesis of biodegradable and functional block copolymers for protein delivery. The 20th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Hong Kong, Oct. 29, Nov. 1, 1998.

  61. Labhasetwar V, Chen W, Goldstein S, Bonadio J, Levy R. DNA coating for gene transfer. 25th Intern. Symp. Control. Rel. Bioact. Mater. Las Vegas, Nevada, June 21-24, 1998.

  62. Chen W, Cohen C, Labhasetwar V, Cui XM, Bonadio J, Goldstein S, Levy R. "Sustained DNA release systems for site-specific gene transfer," NIH Symposium in Bioengineering - Building the Future of Biology and Medicine, p45 Bethesda, 1998.

  63. Labhasetwar V, Goldstein S, Levy R. Biodegradable nanospheres for gene delivery.  Vector Targeting strategies for therapeutic gene delivery, Cold Spring Harbor, NY, March 11-14, 1999.

  64. Labhasetwar V. Biodegradable Nanospheres: Therapeutic Applications. Third International Symposium on Frontiers in Biomedical Polymers including Polymer Therapeutics: From Laboratory to Clinical Practice, Shiga, Japan, May 23-27, 1999.

  65. Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery. Proceeding of the Fourth National Conference of Indian Society of Chemists and Biologists on Drug Research Scenario of 21st Century, Central Drug Research Institute, Lucknow, India, January 28-30, 2000 (Plenary speaker).

  66. Mohamed G. Qaddoumi, Ueda H, Davda J, Labhasetwar V, and Lee Vincent H.L. Uptake of biodegradable nanoparticles in pigmented rabbit conjunctival epithelial cells. Association for Research in Vision and Opthalmology (ARVO meeting, 2000).

  67. Zhou WZ and Labhasetwar V. Transfection of Caco-2 cells by PLGA-nanoparticles. 4th International Biorelated Polymers Symposium, The National ACS Meeting Washington, D.C. Aug. 20-24, 2000.

  68. Mohamed G. Qaddoumi, Ueda H, Davda J, Labhasetwar V, and Lee Vincent HL. Uptake of biodegradable nanoparticles in pigmented rabbit conjunctival epithelial cells. 2000 Annual Meeting, American Association of Pharmaceutical Scientists, Indianapolis, IN, October 29- November 2, 2000.

  69. Labhasetwar V. PLGA-DNA nanoparticles for gene delivery. 2000 Annual Meeting, American Association of Pharmaceutical Scientists Indianapolis, IN, October 29- November 2, 2000.

  70. Zhou WZ and Labhasetwar V. Sustained gene expression with DNA-PLGA nanoparticles in Caco-2 cells, Gene Therapy 2000, Cold Spring Harbor, NY, September 25-29, 2000.

  71. Panyam J, Dali ML, Amidon GL, Levy RJ, Labhasetwar V. Degradation characteristics of PLGA nano- and microparticles: Effect of particle size. AAPS PharmSci Supplement V2, No.4, Abstract No. 3350. AAPS: 2000 Annual Meeting & Exposition, Indianapolis, IN, Oct - Nov 2000.

  72. Panyam J, O'Leary E, Lof J, Labhasetwar V. Localized arterial delivery of nanoparticles for restenosis: Comparative efficacy of two cardiac infusion catheters. AAPS PharmSci Supplement V2, No.4, Abstract No. 3361. AAPS: 2000 Annual Meeting & Exposition, Indianapolis, IN, Oct - Nov 2000.

  73. Panyam J, O’Leary E, Lof J, Labhasetwar V. Biodegradable nanoparticles for restenosis. 32nd Annual Midwest Student Biomedical Research Forum, Omaha, NE, Feb 2001.

  74. Panyam J and Labhasetwar V. Biodegradable dexamethasone nanoparticles for sustained inhibition of smooth muscle cell proliferation. Fifth Annual Cardiovascular Research Symposium, University of Nebraska Medical Center, Omaha, NE, Feb 2001.

  75. Prabha S, Zhou WZ, Labhasetwar V. Nanoparticle-mediated gene transfection is particle size dependent. 32nd Annual Midwest Student Biomedical Research Forum, Omaha, NE, Feb 2001(best oral presentation award to S. Prabha in basic science category).

  76. Qaddoumi MG, Ueda H, Yang J, Davda J, Labhasetwar V, and Lee V.H.L. The mechanism of uptake of PLGA nanoparticles in rabbit conjunctival epithelial cell layers.  Association for Research in Vision and Ophthalmology. Fort Lauderdale, FL, April 29- May 4, 2001.

  77. Panyam J, Prabha S, Sahoo S, Labhasetwar V. Evidence for rapid escape of nanoparticles from endosomes. 5th International Syposium on Polymer Therapeutics: From Laboratory to Clinical Practice, Welsh, UK, January 2-5, 2002.

  78. Qaddoumi MG, Davda J, Labhasetwar V, and Lee V.H.L. Molecular mechanisms mediating the endocytosis of biodegradable PLGA nanoparticles in rabbit conjunctival epithelial cell layers. Association for Research in Vision and Ophthalmology 2002.

  79. Panyam J, Prabha S, Sahoo SK, and Labhasetwar V.  Evidence of rapid escape of nanoparticles from endosomes. Poster presentation at 6th Annual Cardiovascular Research Symposium, University of Nebraska Medical Center, Omaha, NE, Feb 2002.

  80. Prabha S, Panyam J, Labhasetwar V. Fractionated DNA-loaded nanoparticles show different levels of transfection in vitro. 34th Annual Pharmaceutics Graduate Student Research Meeting (PGSRM), Omaha, NE, June 13-15, 2002.

  81. Sahoo SK, Panyam J, Prabha S, Labhasetwar V. Residual polyvinyl alcohol associated with poly (D, L-lactide-co-glycolide) nanoparticles affects their physical and cellular uptake properties. 34th Annual Pharmaceutics Graduate Student Research Meeting (PGSRM), Omaha, NE, June 13-15, 2002.

  82. Panyam J, Prabha S, Sahoo SK and Labhasetwar V. Selective cationization of PLGA nanoparticles in endo-lysosomal compartment results in their cytoplasmic escape. 34th Annual Pharmaceutics Graduate Student Research Meeting (PGSRM), Omaha, NE, June 13-15, 2002. (best oral presentation award to J. Panyam)

  83. Chakravarthi S, Panyam J, Sahoo SK and Labhasetwar V. Polymer degradation if PLGA nano- and microparticles is particle size independent. 34th Annual Pharmaceutics Graduate Student Research Meeting (PGSRM), Omaha, NE, June 13-15, 2002.

  84. Labhasetwar V, Panyam J, Prabha S, Sahoo SK, and Zhou WZ. Nanoparticles for Drug and Gene Delivery. 29th Annual Meeting and Exposition of the Controlled Release Society, July 19-25, 2002, Seoul, South Korea.

  85. J. Panyam and V. Labhasetwar.  Dynamics of endocytosis and exocytosis of PLGA nanoparticles. Poster presentation at the Globalization of Pharmaceutics Education Network, University of Michigan, November 2002, Ann Arbor, MI.

  86. J. Panyam and V. Labhasetwar, Selective cationization of PLGA nanoparticles in end-lysosomal compartment results in their cytoplasmic escape. Oral Presentation at Midwest Student Biomedical Research Forum (MSBRF), Feb 2003, Omaha, NE.

  87. S. Prabha and V. Labhasetwar, Interfacial Properties influence Nanoparticle-Mediated Gene Expression, Oral Presentation at Midwest Student Biomedical Research Forum (MSBRF), Feb 2003, Omaha, NE.

  88. S. Prabha and V. Labhasetwar, Effect of Residual Polyvinyl Alcohol on Nanoparticle-mediated Gene Transfection, Submitted for the American Society of Gene Therapy (ASGT) 6th annual meeting, June 4-8, 2003, Washington, DC.

  89. S. Prabha and V. Labhasetwar, Effect of Polymer Molecular Weight and Composition on Nanoparticle-mediated Gene Transfection, submitted for the American Society of Gene Therapy (ASGT) 6th annual meeting, June 4-8, 2003, Washington, DC.

  90. S. Prabha and V. Labhasetwar, Effect of residual polyvinyl alcohol in nanoparticle-mediated gene expression in breast cancer cells, 30th Annual Meeting and Exposition of the Controlled Release Society, Glasgow, Scotland, July 19-23, 2003.

  91. S. Prabha and V. Labhasetwar, Formulation determinants in nanoparticle-mediated gene expression, 30th Annual Meeting and Exposition of the Controlled Release Society, Glasgow, Scotland, July 19-23, 2003.

  92. J. Panyam and V. Labhasetwar,  Correlating drug-polymer solid-state solubility with Drug loading and release from PLGA/PLA nanoparticles, 30th Annual Meeting and Exposition of the Controlled Release Society, Glasgow, Scotland, July 19-23, 2003.

  93. J. Panyam and V. Labhasetwar, Enhancing therapeutic efficacy by modulating intracellular drug release from nanoparticles, 30th Annual Meeting and Exposition of the Controlled Release Society, Glasgow, Scotland, July 19-23, 2003.

  94. Prabha S, Labhasetwar V. Nanoparticle-mediated wt-p53 gene delivery results in sustained antiproliferative activity in breast cancer cells, The 35th Midwest Student Biomedical Research Forum, Omaha, NE Feb 20, 21, 2004. (Received College of Pharmacy Award for an excellent presentation to S. Prabha)

  95. Sahoo SK, Ma W, Labhasetwar V. Efficacy of transferrin-conjugated paclitaxel-loaded nanoparticles in a murine model of prostate cancer. Abstract #147, Proceedings of the 31st Annual Meeting of the Controlled Release Society, Hawaii, June 12-16, 2004.

  96. Prabha S, Labhasetwar V. Nanoparticle-mediated wt-p53 gene delivery results in sustained antiproliferative activity in breast cancer cells, AAPS: 2004 Annual Meeting & Exposition, Baltimore, MD, November 7-11, 2004. (Received AAPS Graduate Student Award to S. Prabha in Biotechnology sponsored by Pfizer Global Biologics)

  97. Marco M, Jain T, Leslie-Pelecky D, Labhasetwar V. Magnetic studies of Fe3O4 nanoparticles coated with oleic acid and Pluronic block copolymer, 49th MMM Conference, Jacksonville, FL, November 7-11, 2004.

  98. Reddy MK, Labhasetwar V. Effect of recombinant human erythropoietin on neointima formation in rat carotid artery model of restenosis. 9th Annual Cardiovascular Research Symposium, University of Nebraska Medical Center, Omaha, NE, Feb 2005.

  99. Sahoo SK and Labhasetwar V. Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention, 32nd Annual Meeting of the Controlled Release Society, Miami, FL, June 18-22, 2005.

  100. Jain T. K., Morales MA, Sahoo S. K., Leslie-Pelecky DL and Labhasetwar V. Bilayer stabilized iron-oxide manoparticles: a drug carrier system for anticancer agents, 32nd Annual Meeting of the Controlled Release Society, Miami, FL, June 18-22, 2005.

  101. Ghorpade A., Sahoo P, Sahoo SK, Borgmann K. Persidsky R and Labhasetwar V. Ritonavir nanoparticles inhibit productive replication of HIV-1ADA in MDM, 32nd Annual Meeting of the Controlled Release Society, Miami, FL, June 18-22, 2005.

  102. Reddy M, Ghorpade A. Labhasetwar V. Neuroprotective effect of SOD-loaded nanoparticles under oxidative stress, 32nd Annual Meeting of the Controlled Release Society, Miami, FL, June 18-22, 2005.

  103. Sanjeeb K. Sahoo, Amulya K. Panda, Jayme Horning, Tapan K. Jain and Vinod Labhasetwar. Tissue model for in vitro evaluation of anticancer agents, 33rd Annual Meeting & Exposition of the Controlled Release Society, July 22 - 26, 2006, Vienna, Austria.

Invited Presentations

  1. Controlled Release Drug Delivery Systems for Cardiovascular Applications, National Institute of Immunology, New Delhi, December 15, 1993.

  2. Drug Carriers for Gene Therapy, 7th Annual Patrick John Niland Lectureship, University of Michigan, March 29, 1994. 

  3. Nanoparticle Drug Delivery System, NeoRx Corporation, Seattle, WA, October 4, 1994.

  4. Iontophoresis for Modulation of Cardiac Drug Delivery, ASAIO Cardiovascular Science and Technology Conference, Washington, DC, December 9, 1994.

  5. Nanoparticles for Intra-arterial Localization in Restenosis, NATO Advanced Study Seminars in Gene Therapy, Cape Sounion Beach, Greece, July 1, 1995.

  6. Nanoparticles as a Drug Delivery System: Therapeutic Potentials and Promise, College of Pharmacy and Allied Health Sciences, University of Montana, September 16, 1996.

  7. Local Pharmacotherapy-Antiarrhythmics, 2nd International Conference on Local Cardiovascular Drug Delivery, Cambridge, MA, October 15, 1996.

  8. Nanoparticles-a drug delivery system for restenosis, vaccine, and gene therapy, The Texas Tech University Health Center, School of Pharmacy, Amarillo, TX, February 3, 1997.

  9. Nanoparticles-a drug delivery system for restenosis, vaccine, and gene delivery, Department of Pharmaceutical Sciences, University of Tennessee, February 10, 1997.

  10. Biodegradable nanospheres for drug delivery applications. Conference on Pharmaceutical Science and Technology, Fine Particle Society, Dallas, TX, April 1-3, 1998.

  11. Biodegradable Nanospheres: Therapeutic Applications. Third International Symposium on Frontiers in Biomedical Polymers Including Polymer Therapeutics: From Laboratory to Clinical Practice, Shiga, Japan, May 23-27, 1999.

  12. Biodegradable Nanoparticles for Drug and Gene Delivery. Central Drug Research Institute, Lucknow, India, January 28-30, 2000 (plenary lecture).

  13. Transfection of Caco-2 Cells by PLGA-Nanoparticles. 4th International Biorelated Polymers Symposium, The National ACS Meeting Washington, D.C. Aug. 20-24, 2000.

  14. PLGA-DNA Nanoparticles for Gene Delivery, American Association of Pharmaceutical Scientists, 2000 Annual Meeting, Indianapolis, IN, October 29- November 2, 2000.

  15. Nanoparticles for Drug and Gene Delivery. 29th Controlled Release society meeting; July 20-25, 2002, Seoul, South Korea.

  16. Rapid Endosomal Escape of Nanoparticles: Therapeutic Implications, 54th Indian Pharmaceutical Congress; Dec 12-14, 2002, Pune, India.

  17. Intracellular trafficking of nanoparticles: Dr. D. Y. Magrulkar memorial lecture, Department of Pharmaceutical Sciences, Nagpur University, India, December 16, 2002.

  18. Rapid endo-lysosomal escape of nanoparticles: Mechanism and therapeutic applications for drug and gene delivery: Minisymposium on Nanomedicine and Drug Delivery organized by the Nanotechnology Researchers Network Center of Japan and the University of Nebraska Medical Center, Omaha, Jan 6, 2003.

  19. Nanoparticles for Drug and Gene Delivery, Center for Neurovirology and Neurodegenerative Disorders, UNMC, May 19, 2003.

  20. Intracellular trafficking of Nanoparticles, Department of Physiology and Biophysics, UNMC, September 5, 2003.

  21. Molecular Mechanism of Gene Delivery with Nanoparticles, Oklahoma Health Science Center, Oklahoma City, OK. May 21, 2004.

  22. Nanosystems in overcoming issues in drug/gene delivery, College of Pharmacy, Wayne State University, Detroit, MI. December 15, 2004.

  23. Gene Delivery, 6th Controlled Release Society meeting, Indian Chapter, Bombay, India, February 18, 2005.

  24. Nanosystems and drug/gene delivery, Central India Pharmacy Promotion and Research Association (CIPRA), India. Feb 27, 2005.

  25. Nanomedicine and drug delivery, Sankara Nethralaya, Chennai, India, March 1, 2005.

  26. Nanosystems in overcoming issues in drug/gene delivery, University of Delhi, India, March 3, 2005.