Vinod Labhasetwar, Ph.D.

 

      

SANJEEB K. SAHOO, Ph.D.

M.S. (Chemistry), Delhi University, India.

PhD (Chemistry), Delhi University, India.

Post-doc, Dept. of Pharm. Sci., UNMC, Omaha

Phone: (402) 559-2407

Fax: (402) 559-9543

Email: ssahoo@unmc.edu

 

Research Interest |Academic Qualifications |Professional Experience |Honors |Affiliation |Patents |Publications |Presentations |

 

Research Interest

  • Preparation and characterization of polymeric systems (nanoparticles and micelles) for drug delivery.

  • Conjugation of different macromolecules to water insoluble anticancer drugs for tumor targeting.

Academic Qualifications

 

1992 - 94

1995 - 99

 

M.S. (Physical Chemistry), University of Delhi, 1994

Ph.D. (Physical Chemistry), University of Delhi

Title of Ph.D. Dissertation:  “Studies of nanometer size hydrogel particles as drug delivery systems” 

 

Professional Experience

 

2001 – present

 

1999 – 2001 

 

 

1999 

Research Fellow, Department of Pharmaceutical Sciences, University Of Nebraska Medical Center.        

Research Fellow, JSPS postdoctoral fellow with Prof. Hiroshi Maeda at Department of Microbiology, Kumamoto University, School of Medicine, Kumamoto, Japan

Scientist, Dabur Research Foundation. Dabur India Ltd., India.                  

 

Honors and Awards

 

  • Postdoctoral fellowship from the American Heart Association (2002-2004).

  • Postdoctoral fellowship from Japanese society for promotion of science (JSPS), Government of Japan (1999-2001).

  • U.S. Patent No-5, 874,111 “Process for the preparation of highly monodispersed hydrophilic polymeric nanoparticles”.

  • U. S. Patent No-6, 365, 91 “ Formulation of Paclitaxel, its derivatives or its analogs entrapped in to nanoparticles of polymeric micelles, process for preparing same and the use there of. The patented formulation is under clinical trial by Dabur India Ltd, New Delhi.

  • Visiting research fellow at Prof. S. S. Davis laboratory, University of Nottingham, U.K in Jan-Feb 1998.

  • Travel grant from the School of Pharmacy, University of London to attend the 3rd International symposium on polymer therapeutics from laboratory clinical practice, January 7th –9th 1998, School of Pharmacy University of London.

  • Junior Research Fellowship (1996-98) and Senior Research Fellowship (1998-1999), University Grant Commission, Government of India.

  • Secured (84.07 percentile)All India Graduate Aptitude Test in Engineering  (GATE) in 1996

 

Professional  affiliation

  • American Association of Pharmaceutical Scientists

  • Controlled Release Society

  • American Heart Association

Patents

  1. "A method of preparation of drug loaded hydrophilic polymeric nanoparticles of size less than 100 nm.”: A. N. Maitra, P. K. Ghosh, T. K .De and S. K. Sahoo, U.S patent No. 5,874,111, Japan patent No 330406/98, European patent No.973031271, Indian patent no.  2350/DEL/96 dated 20 Dec. 96

  2. "Formulation of paclitaxel, its derivatives or its analogs entrapped into nanoparticles of polymeric micelles.” A. N. Maitra, P. K. Ghosh, S. K. Sahoo and Dabur Research Foundation, Sahibabad (UP), India, U. S.-patent No- U012204-8.

  3.  "A Process for the preparation of pharmaceutical formulation of paclitaxel entrapped in to polymeric micelles nanoparticles for the treatment of cancer.”  A. N. Maitra, P. K. Ghosh, S. K. Sahoo and Dabur Research Foundation, Sahibabad (UP), India, Invention disclosure submitted to Indian government in 1999.

  4. "A pharmaceutical composition of paclitaxel for the treatment of pathological conditions arising out of excessive proliferation of cells.” A. N. Maitra, P. K. Ghosh, S. K. Sahoo and Dabur Research Foundation, Sahibabad (UP), India,  Invention disclosure submitted to Indian government in 1999.

Publications

  1. Sahoo S, Jain T, Reddy M, Labhasetwar V: Nano-sized carriers for drug delivery, in "Nanobiotechnology", (Ed. Elan Levy), The Humana Press Inc., Totowa, NJ, 2006 (in press).
  2. Sahoo S, Labhasetwar V: Nanoparticle Interface: An Important determinant in nanoparticle-mediated drug/gene delivery, in "Nanoparticle Technology for Drug Delivery", (Eds. Gupta and Kompella), Mercel Dekker, Inc. New York, NY, 2005

  3. Sahoo SK, Labhasetwar V. Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention. Mol. Pharm., 2005 (Published on-line on June 21, 2005).

  4. T. K. Jain, M. A. Morales, S. K. Sahoo, D. L. Leslie-Pelecky and V. Labhasetwar; (2005) Iron-oxide nanoparticles for sustained delivery of anticancer agents. Molecular Pharmaceutics 2, 194-205, 2005.

  5. S. K. Sahoo, A. K. Panda and V. Labhasetwar; Characterization of porous PLGA/PLA microparticles as a scaffold for three dimensional growth of breast cancer cells Biomacromolecules. 6, 1132-1139, 2005.

  6. S. K. Sahoo, W. Ma and V. Labhasetwar; Efficacy of a transferrin-conjugated paclitaxel loaded nanoparticles in a murine model of prostate cancer.
    Int. J. of Cancer. 112, 335-340, 2004. (Listed on NCI web site under NCI Alliance for Nanotechnology in Cancer)

  7. S. K. Sahoo, and V. Labhasetwar. Nanotech approaches in drug delivery and Imaging.  Drug Discovery Today. 8 (24), 1112-1120, 2003. (Invited Review, Listed as top-three most down loaded article by Drug Discovery during Sept 2003 to Sept 2004)

  8. T. Sawa, S. K. Sahoo and H. Maeda; Water-soluble polymer therapeutics with a special emphasis on cancer chemotherapy, Arshady R, editor, in: Polymeric Biomaterials, The PBM Series, Vol 1: Introduction to Polymeric Biomaterials, Citus Books, London 2003; 233-61

  9. J. Panyam, M. P. Dhali, S. K. Sahoo, Wenxue Ma, S. Chakravarthi, A. G. Amidon, R. J. Levy and V. Labhasetwar; Polymer degradation of PLGA nano and micro particles is particle size independent. J. of Control. Release. 92, 173-187, 2003. (Listed as the top-twelfth most downloaded article by J.Cont. Rel. during April 2003 to March 2004)

  10. J. Panyam, S. K. Sahoo, S. Prabha, V. Labhasetwar; Fluorescence and Electron microscopy probes for poly (D,L-lactide-co-glycolide) Nanoparticles. Int. J. Pharm, 262(1-2):1-11, 2003. (Listed as the top-three most downloaded article by Int. J. Pharm during April 2003 to March 2004)

  11. J. Fang, T.Sawa, T. Akaike, T. Akuta, S. K. Sahoo, G. Khaled, A. Hamada, and H. Maeda; In vivo antitumor activity of pegylated zinc protoporphyrin: targeted inhibition of heme oxygenase in solid tumor ; Cancer Research, 63(13):3567-74, 2003.

  12. D. J. Bharali, S. K. Sahoo, S. Majumudar and A. N. Maitra; Nanometer size polyvinyl pyrrolidone nanoparticles as drug delivery carriers; J. Colloid and Interface Science, 258(2),415-423, 2003.

  13. S. K. Sahoo, J. Panyam, S. Prabha and V. Labhasetwar; Residual polyvinyl alcohol associated with poly (D, L-lactide-co-glycolide) nanoparticles affects their physical and cellular uptake properties J. Control. Release. Vol. 82,105-114, 2002.

  14. S. K. Sahoo, T. Sawa, J. Fang, S. Tanaka, T. Akaike and H. Maeda; PEGylated Zinc protophorphyrin: a water-soluble hemeoxygenase inhibitor with tumor targeting capacity. Bioconjugate Chemistry, 13 (5), 1031-1038, 2002.

  15. J. Panyam, W. Z. Zhou, S. Prabha, S. K. Sahoo, V. Labhasetwar; Rapid endo-lysomal escape of poly (D, L-lactide-co-glycolide) nanoparticles: implication for drug and gene delivery. The FASEB Journal, Vol. 16, 1217-1226, 2002.

  16. U. Gaur, S. K. Sahoo, T. K. De, P.C. Ghosh, A.N. Maitra and P. K. Ghosh; Bio-distribution of fluoresceinated dextran using novel nanoparticles evading reticuloendothelial system, Int. J. Pharm., 202, 1-10, 2000.

  17. S. K. Sahoo, T. K. De, P. K. Ghosh and A.N. Maitra; pH & thermo-sensitive hydrogel nanoparticles; Journal of Colloid and Interface Sci., 206, 361-368, 1998.

 

Abstracts/Presentations

  1. S. K. Sahoo, and V. Labhasetwar; Enhanced antiproliferative activity of Transferrin conjugated paclitaxel nanoparticles is mediated via sustained intracellular drug retention. Abstract submitted for 32nd International Symposium on Controlled Release of Bioactive Materials, June 18-22, 2005, Miami, Florida, USA.

  2. S. K. Sahoo, Ma W and V. Labhasetwar; Efficacy of a transferrin-conjugated paclitaxel loaded nanoparticles in a murine model of prostate cancer. Symposium on biomedical applications of magnetic nanostructures. October 8, 2004, University of Nebraska at Lincon, Nebraska, USA.

  3. S. K. Sahoo, J. Panayam, S. Prabha and V. Labhasetwar; Residual polyvinyl Alcohol associated with poly (D, L-lactide-co-glycolide) nanoparticles affects their physical and cellular uptake properties. Symposium on biomedical applications of magnetic nanostructures. October 8, 2004, University of Nebraska at Lincon, Nebraska, USA.

  4. E. Neilson, S. K. Sahoo, V. Labhasetwar. Doxorubicin-loaded Poly Lactide nanoparticles significantly decreases viability of MCF-7 breast cancer cells and cellular uptake may be improved without the use of polyvinyl alcohol as an emulsifier. 29th Annual West Coast Biological Sciences Under Graduate Research Conferences, 2004 Point Loma Nazarene University, San Diego, California, USA.

  5. S. K. Sahoo, Ma W and V. Labhasetwar; Efficacy of a transferrin-conjugated paclitaxel loaded nanoparticles in a prostate cancer mice model. Proceeding International Symposium on Controlled Release of Bioactive Materials; 2004, Honululu, Hawaii, USA.

  6. J. Panayam, S. Prabha, S. K. Sahoo and V. Labhasetwar; Selective cationization of PLGA nanoparticles in endo-lysosomal compartment results in their cytoplasmic escape. The 34th Annual Midwest Student Biomedical Research Forum, Feb 2003, Omaha, NE

  7. S. K. Sahoo, J. Panayam, S. Prabha and V. Labhasetwar; Residual Polyvinyl Alcohol Associated with poly (D, L-lactide-co-glycolide) nanoparticles affects their physical and cellular uptake properties. Globalizatiom of Pharmaceutics Education Network, GPEN 2002, November 6-8, University of Michigan, Ann Arbor, USA.

  8. J. Panyam, S. Prabha, S. K. Sahoo, and V. Labhasetwar; Selective cationization of PLGA nanoparticles in endo-lysosomal compartment, results in their cytoplasmic Escape. Annual Post-Graduate Student Research Meeting (PGSRM) June 15th –18th, 2002. University of Nebraska Medical Center, Omaha, USA.

  9. S. K. Sahoo, J. Panayam, S. Prabha and V. Labhasetwar; Residual polyvinyl Alcohol associated with poly (D, L-lactide-co-glycolide) nanoparticles affects their physical and cellular uptake properties. Annual Pharmaceutics Post-Graduate Student Research Meeting (PGSRM), June 15th –18th, 2002. University of Nebraska Medical Center, Omaha, USA,

  10. S. Chakravarthi, J. Panayam, S. K. Sahoo and V. Labhasetwar; Polymer degradation of PLGA nano and micro particles is particle size independent. Pharmaceutics Graduate Student Research Meeting (PGSRM), June 15th –18th, 2002. University of Nebraska Medical Center, Omaha, USA.

  11. V. Labhasetwar, J. Panyam, S. Prabha and S. K. Sahoo; Nanoparticles for drug and gene delivery. Proceeding International Symposium on Controlled Release of Bioactive Materials; 2002, Seoul, South Korea.

  12. J. Panyam, S. Prabha, S. K. Sahoo, and V. Labhasetwar; Evidence for rapid escape of nanoparticles from endosomes. 5th International Symposium on Polymer Therapeutics, From Laboratory to Clinical Practice, January 2nd –4th, 2002, Welsh, UK.

  13. T. Sawa, S. K. Sahoo, J. Fang, T. Tanaka, T. Akaike and H. Maeda; PEGylated Zinc protophorphyrin: a water-soluble heme oxygenase inhibitor with potent anti-tumor activity. 8th Annual meeting of the Oxygen Society, November 15th - 19th, 2001, Research Triangle Park, North Carolina, USA.

  14. S. K. Sahoo, T. Sawa and H. Maeda; “Preparation and characterization of cross-linked polymeric micelles of N-isopropyl-acrylamide and vinylpyrrolidone for the Delivery of Anticancer Drug Paclitaxel” Japanese Biochemical Society, October 11th-14th, 2000, Yokohama, Japan

  15. A. N. Maitra, S. K. Sahoo, U. Gaur, P. C. Ghosh and P. K. Ghosh; RES evading long circulating hydrophilic nanoparticles. Proceeding International Symposium on Controlled Release of Bioactive Materials, 25,168-169, Las Vegas, U.S.A.,

  16. A.N. Maitra, P.K. Ghosh and S. K. Sahoo; pH and thermo-sensitive hydrogel nanoparticles. Proceeding International Symposium on Controlled Release of Bioactive Materials, 25, 234-235. 1998, Las Vegas, U.S.A.,

  17. S. K. Sahoo, P. K. Ghosh, T. K. De, U. Gaur, P.C. Ghosh and A. N. Maitra; (1998) Long circulating hydrophilic nanoparticles. 3rd International symposium on polymeric therapeutics from laboratory to clinical practice, January 7th- 10th, 1998, University of London, U.K.

  18. A. N. Maitra, S. K. Sahoo, P. K. Ghosh and T. K. De; Particle engineering of drug loaded nanoparticles and their potential drug targeting application preparation through microemulsion. 2nd International symposium on polymeric therapeutics from laboratory to clinical practice, April 18-20, 1997, Kumamoto University, Japan.

  19. S. K. Sahoo, T. K. De and A. N. Maitra; Controlling the size of the hydrophilic polymeric nanoparticles preparation through microemulsion October 18-20, 1997, Center of Studies in Surface Science & Technology, Sambalpur University, Jyoti Vihar, Burla, India.

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