Vinod Labhasetwar, Ph.D.

 

 

Peer Reviewed Publications

  1. Labhasetwar V, Puranik PK, Dorle AK: Evaluation of shellac-glycerol esters as anhydrous binding agents. Indian J. Pharm. Sci. 50: 343-345,1988. 

  2. Labhasetwar V, Joshi SV, Dorle AK: A study on dielectric constant of microcapsules during aging. J. Microencapsulation 5: 339-341, 1988. 

  3. Narsimhan R, Labhasetwar V, Lakhotia CL, Dorle AK: Timed-release noscapine microcapsules. Indian J. Pharm. Sci. 50: 120-122, 1988.

  4. Labhasetwar V, Puranik PK, Dorle AK: Evaluation of shellac-glycerol esters as microencapsulating materials. J. Microencapsulation 6:115-118, 1989.

  5. Labhasetwar V, Dorle AK: Nanoparticles-A colloidal drug delivery system for primaquine and metronidazole. J. Controlled Release 12:113-119, 1990.

  6. Labhasetwar V, Puranik PK, Dorle AK: Study on shellac-glycerol esters as microencapsulating materials. II Quantitative correlation between physicochemical properties and drug release. J. Microencapsulation 7: 553-554, 1990.

  7. Labhasetwar V, Levy RJ: Implants for site-specific drug delivery. J. Applied Biomaterials 2: 211-212, 1991.

  8. Labhasetwar V, Dorle AK: A study on the zeta potential of microcapsules during aging. J. Microencapsulation 8: 83-85, 1991. 

  9. Labhasetwar V, Levy RJ: Polymer systems for cardiovascular drug delivery. Polymer News 17: 336-342, 1992. (Leading Article) 

  10. Labhasetwar V, Kadish A, Underwood T, Sirinek M, Levy RJ: The efficacy of d-sotalol polyurethane epicardial implants for ventricular arrhythmias due to acute ischemia in dogs. J. Controlled Release 23:75-86, 1993. 

  11. Labhasetwar V, Deshmukh SV, Dorle AK: Studies on some crystalline forms of ibuprofen. Drug Development and Industrial Pharmacy. 19(6): 631-641, 1993.

  12. Pathak YV, Labhasetwar V: Scanning electron microscopy applications in characterizing and evaluating drug delivery systems. Cells & Materials 3(l):51-66, 1993. 

  13. Labhasetwar V, Underwood T, Gallagher M, Murphy G, Langberg J, Levy RJ: Sotalol controlled release systems for arrhythmias: in vitro characterization, invivo drug disposition, and electrophysiologic effects. J. Pharm. Sci. 83 (2): 156-164, 1994. 

  14. Choudhari KB, Labhasetwar V, Dorle AK: Liposomes as carrier for oral administration of insulin: effect of formulation factors. J. Microencapsulation 11 (3):319-325, 1994. 

  15. Labhasetwar V, Dorle AK: Dielectric constant during emulsification. Drug Development and Industrial Pharmacy 20 (13): 2135-2141, 1994. 

  16. Schwendeman SP, Amidon GL, Labhasetwar V, Levy RJ: Modulated drug release using iontophoresis through heterogeneous cation-exchange membranes II. influence of cation-exchanger content on membrane resistance and characteristic times. J. Pharm. Sci. 83: 1282-1294, 1994. 

  17. Labhasetwar V, Underwood T, Gallagher M, Langberg J, Levy RJ: Epicardial controlled release ibutilide: Effects on defibrillation threshold and electrophysiologic parameters. J. Cardiov. Pharmacol. 24: 826-840, 1994. 

  18. Labhasetwar V, Mohan MS, Dorle AK: A study on zeta potential and dielectric constant of liposomes. J. Microencapsulation 11, 663-668, 1994. 

  19. Labhasetwar V, Underwood T, Schwendeman S, Levy RJ: Iontophoresis for modulation of cardiac drug delivery. Proc. Natl. Acad. Sci. USA 92, 2612-2616, 1995. 

  20. Villa AE, Guzman LA, Poptic EJ, Labhasetwar V, D'Souza S, Farrel CL, Plow EF, Levy RJ, DiCorleto P, Topol, EJ: The effects of antisense c-myb oligonucleotides on vascular cell proliferation and response to vessel wall injury. Cir. Res. 76, 505-513, 1995. 

  21. Schwendeman S, Labhasetwar V, Levy RJ: Model features of a cardiac iontophoretic drug deliver implant. Pharm. Res. 12, 790-795, 1995. 

  22. Labhasetwar V, Levy RJ: Novel delivery of antiarrhythmic agents. Clinical Pharmacokinetics 29, 1-5, 1995. (Leading Article) 

  23. Levy RJ, Labhasetwar V, Song C, Lerner E, Chen W, Vyavahare N, Qu X: Polymeric drug delivery systems for treatment of cardiovascular calcification, arrhythmias, and restenosis. J. Controlled Release 36, 137-147, 1995. 

  24. Levy RJ, Labhasetwar V, Strickberger SA, Underwood T, Davis J: Controlled release implant dosage forms for cardiac arrhythmias-review and perspectives. Drug Delivery 3,137-142, 1996. 

  25. Guzman L, Labhasetwar V, Song C, Jang Y, Lincoff AM, Levy RJ, Topol E: Local intraluminal infusion of biodegradable polymeric nanoparticles: a novel approach for prolonged drug delivery after balloon angioplasty. Circulation 94,1441-1448, 1996. 

  26. Desai M, Labhasetwar V, Amidon G, Levy RJ: Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm. Res. 13, 1837-1844, 1996. 

  27. Song C, Labhasetwar V, Murphy M, Qu X., Humphrey WR, Shebuski RJ, Levy RJ: Formulation and characterization of biodegradable nanoparticles for intravascular local drug delivery. J. Controlled Release 43, 197-212, 1997. 

  28. Song C, Labhasetwar V, Levy RJ: Controlled release of U-86983 from double layer PLGA films: Effect of additives on release rates and kinetics. J. Controlled Release 45, 177-192, 1997.

  29. Labhasetwar V, Chen B, Muller D, Bonadio J, Ciftci K, March K, Levy RJ: Gene-based therapies for restenosis. Adv. Drug Del. Rev. 24, 109-120, 1997. 

  30. Labhasetwar V, Song C, Levy RJ: Nanoparticles drug delivery system in restenosis. Adv. Drug Del. Rev. 24, 63-85, 1997. 

  31. Humphrey R, Erickson L, Simmons C, Northrup J, Wishka D, Morris J, Labhasetwar V, Song C, Levy RJ, Shebuski RJ: The effect of intramural delivery of polymeric nanoparticles loaded with the antiproliferative 2-aminochromone U-86983 on neointimal hyperplasia development in balloon­ injured porcine coronary arteries. Adv. Drug Del. Rev. 24, 87-108, 1997. 

  32. Gottsauner-Wolf M, Jang Y, Lincoff AM, Cohen JL, Labhasetwar V, Poptik EJ, Forudi F, Guzman L, DiCorletto PE, Levy RJ, Topol EJ, Ellis SG: Influence of local delivery of the protein tyrosine kinase receptor inhibitor tyrphostin-47 on smooth muscle cell proliferation in the rat carotid balloon injury model. American Heart J. 133 (3), 329-334, 1997. 

  33. Desai M, Labhasetwar V, Walter E, Levy RJ, Amidon G: Mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. Pharm. Res. 11, 1568-1573, 1997.

  34. Labhasetwar V, Strickberger A, Davis J, Underwood T, Levy RJ: Prevention of acute inducible atrial flutter in dogs using an ibutilide-polymer coated pacing electrode. J. Cardiov. Pharmacol. 31, 449­-455, 1998. 

  35. Song C, Labhasetwar V, Xiumin C, Underwood T, Levy RJ: Arterial uptake of biodegradable nanoparticles for intravascular local drug delivery: results in an acute dog model. J. Controlled Release 54, 201-211, 1998.  

  36. Labhasetwar V, Song C, Humphrey W, Chen B, Muller DMW, Shebuski RJ, Levy RJ: Arterial uptake of biodegradable nanoparticles: effect of surface modifications. J. Pharm. Sci. 87, 1229-1234, 1998. 

  37. Labhasetwar V, Bonadio J, Goldstein S, Chen W, Levy RJ: A DNA controlled release coating for gene transfer: transfection in skeletal and cardiac muscles. J. Pharm. Sci. 87, 1347-1350, 1998. 

  38. Song C, Sun H, Yang J, Wang P, Labhasetwar V, Levy, R: Synthesis of biodegradable and functional block copolymers for protein delivery, Proceedings of the 20th Annual International Conference of the IEEE. 6, 2897-2900, 1998.

  39. Labhasetwar V, Bonadio J, Goldstein S, Levy RJ: Gene trasfection using biodegradable nanospheres: results in tissue culture and a rat osteotomy model. Colloids and Surfaces B: Biointerfaces 16, 281-290, 1999. 

  40. Desai M, Hilfinger J, Amidon G, Levy RJ, Labhasetwar V: Immune response with biodegradable nanospheres and alum: studies in rabbits using staphylococcal entertoxin B-toxoid. J. Microencapsulation 17, 215-225, 2000. 

  41. Zhou W and Labhasetwar V: Transfection of Caco-2 cells by PLGA-nanoparticles.  Polymer Preprints 2000, 41, 1635-1636, 2000. 

  42. Raghuvanshi R, Misra A, Talwar GP, Levy RJ, Labhasetwar V: Enhanced immune response with a combination of alum and biodegradable nanoparticles containing tetanus toxoid. J. Microencapsulation 18, 723-732, 2001.

  43. Davda J and Labhasetwar V: An update on angiogenesis therapy. Critical Reviews in Eukaryotic Gene Expression 11, 1-21, 2001. (Invited Review) 

  44. Davda J and Labhasetwar V. Characterization of nanoparticle uptake by endothelial cells, Int. J. Pharm. 233, 51-59, 2002.  (Drug Discovery Gateway featured article, Feb 5, 2004)

  45. Sahoo S, Panyam J, Prabha S, Labhasetwar V. Residual polyvinyl alcohol associated with poly (D,L lactide-co-glycolide) nanoparticles affects their physical and cellular uptake properties, J. Controlled Release, 82,105-114, 2002.

  46. Panyam J, Zhou WZ, Prabha S, Sahoo S, Labhasetwar V. Rapid endo-lysomal escape of poly (D, L-lactide-co-glycolide) nanoparticles: implication for drug and gene delivery. FASEB J. 16, 1217-1226, 2002.   (Listed on NCI web site under NCI Alliance for Nanotechnology in Cancer)

  47. Panyam J, Lof J, O’Leary E, Labhasetwar V, Efficiency of DispatchÒ and InfiltratorÒ cardiac infusion catheters in arterial localization of nanoparticles in a porcine coronary model of restenosis, J. Drug Targeting, 10(6), 517-523.

  48. Prabha S, Zhou WZ, Panyam J, Labhasetwar V. Size-dependency of nanoparticle-mediated gene transfection: Studies with fractionated nanoparticles. Int. J. Pharm. 244 (1-2), 105-115, 2002. 

  49. Panyam, J. and Labhasetwar, V. Dynamics of endocytosis and exocytosis of poly (DL-lactide-co-glycolide) nanoparticles in vascular smooth muscle cells. Pharm Res, 20(2), 210-218, 2003.

  50. Panyam J, Labhasetwar V. Biodegradable nanoparticles for drug and gene delivery to cells and tissue, Adv. Drug Del. Rev. 55, 329-347, 2003. (Invited Review, Listed as top-six most popular ScienceDirect articles in Pharmaceutical Sciences in 2003, ScienceDirect Listed as Top 4th article published in Adv. Drug Del. Rev.)

  51. Panyam J, Sahoo S, Prabha S,  Labhasetwar V. Fluorescence and electron microscopy probes for cellular and tissue uptake of poly (D, L-lactide-co-glycolide) nanoparticles, Int. J. Pharm. 262, 1-11, 2003. 

  52. Panyam J, Dali M, Sahoo S, Ma W, Chakravarthi S, Amidon G, Levy RJ, Labhasetwar V. Polymer degradation and in vitro release of a model protein from poly(D,L-lactide-co-glycolide) nano- and microparticles. J. Control. Rel. 92, 173-187, 2003.

  53. Qaddoumi MG, Gukasyan HJ, Davda J, Labhasetwar V, Kim KJ, Lee VHL. Clathrin and caveolin-1 expression in primary pigmented rabbit conjunctival epithelial cells: Role in PLGA nanoparticle endocytosis, Molecular Vision 9,559-568, 2003.

  54. Sahoo S, Labhasetwar V. Nanotech approaches to drug delivery and imaging. Drug Discovery Today 8, 1112-1120, 2003. (Invited Review, Listed as top-three most down loaded article by Drug Discovery during Sept 2003 to Sept 2004)

  55. Prabha S, Labhasetwar V. Critical determinants in PLGA/PLA nanoparticle-mediated gene delivery, Pharm. Res. 21, 354-364, 2004. (Listed on NCI web site under NCI Alliance for Nanotechnology in Cancer)

  56. Panyam J, and Labhasetwar V. Sustained Cytoplasmic Delivery of Drugs with Intracellular Receptors Using Biodegradable Nanoparticles, Molecular Pharmaceutics 1, 1, 77-84, 2004. (Featured in Modern Drug Discovery, March 2004)

  57. Ma W, Yu H, Wang Q, Jin H, Solheim J, Labhasetwar V. A novel approach for cancer immunotherapy: tumor cells with anchored superantigen SEA generate effective antitumor immunity, J. Clin. Immunology 24, 294-301, 2004.

  58. Panyam J, Labhasetwar V. Targeting intracellular targets, Current Drug Delivery 1 (3), 235-247, 2004. (Invited Review)

  59. Satturwar PM, Fulzele SV, Panyam J, Mandaogade PM, Mundhada DR, Gogate BB, Labhasetwar V, Dorle AK. Synthesis and evaluation of rosin derivatives for pharmaceutical coating. Int. J. Pharm. 270(1-2), 27-36, 2004.

  60. Qaddoumi MG, Hideo Ueda, Johnny Yang, Davda J, Labhasetwar V, Lee VHL. The characteristics and mechanisms of uptake of PLGA nanoparticles in rabbit conjunctival epithelial cell layers, Pharm. Res. 21, 641-648, 2004. (Featured on the cover page of the issue)

  61. Panyam J, Williams D, Dash A, Leslie-Pelecky D, Labhasetwar V: Solid-state solubility of drug in PLGA/PLA polymers influences encapsulation and release of hydrophobic drugs from nanoparticles. J. Pharm. Sci. 93, 1804-1814, 2004.

  62. Prabha S, Labhasetwar V: Nanoparticle-mediated wt-p53 gene delivery results in sustained antiproliferative activity in breast cancer cells, Mol. Pharm. 1(3), 211-219, 2004. (Featured in Chemical & Engineering News in May 2004 under Nanofocus)

  63. Sahoo SK, Ma W, Labhasetwar V. Efficacy of transferrin-conjugated paclitaxel-loaded nanoparticles in a murine model of prostate cancer.  Int. J. Cancer Res. 112, 335-340, 2004. (Listed on NCI web site under NCI Alliance for Nanotechnology in Cancer)

  64. Sahoo SK, Panda AK, Labhasetwar V. Characterization of porous PLGA/PLA microparticles as a scaffold for three dimensional growth of breast cancer cells. Biomacromolecules, 6, 1132-1139, 2005.

  65. Davda J, Labhasetwar V. Sustained activity of vascular endothelial growth factor following encapsulation in nanoparticles. J. Biomed. Nanotechnology. 1,74-82, 2005. (Invited article for the inaugural issue)

  66. Vasir JK, Reddy MK, Labhasetwar V. Nanosystems in drug targeting: opportunities and challenges. Current Nanoscience, 1(1), 45-62, 2005. (Invited review for the inaugural issue)

  67. Morales MA, Jain TK, Labhasetwar V, Leslie-Pelecky DL. Magnetic studies of iron oxide nanoparticles coated with oleic acid and Pluronic® block copolymer. J. Appl. Phys., 97 (10Q901), 1-3, 2005.

  68. Jain TK, Morales MA, Sahoo SK, Leslie-Pelecky DL, Labhasetwar V. Ion-oxide nanoparticles for sustained delivery of anticancer agents. Mol. Pharm., 2, 194-205, 2005.

  69. Sahoo SK, Labhasetwar V. Enhanced antiproliferative activity of transferrin-conjugated paclitaxel-loaded nanoparticles is mediated via sustained intracellular drug retention. Mol. Pharm., 2, 373-383, 2005.

  70. Vasir JK, Labhasetwar V. Targeted drug delivery in cancer therapy. Technology in Cancer Research and Treatment. 4, 363-374, 2005.

  71. Labhasetwar V. Nanotechnology for Drug/Gene Therapy: the importance of understanding molecular mechanisms of delivery, Current Opinion in Biotechnology, 16:674–680, 2005.

  72. Labhasetwar V. What is next for nanotechnology, Editorial, Journal of Biomedical Nanotechnology, 1, 373-374, 2005

  73. Vasir JK, Labhasetwar V. Polymeric nanoparticles for gene delivery, Expert Opinion on Drug Delivery, 2006 May;3(3):325-344.

 

Book Chapters 

  1. Labhasetwar V: Rectal administration of drugs. Pharmagazine 25, 1984.

  2. Labhasetwar V: Immunoassays and application of monoclonal antibodies. Marine and Human Monoclonal Antibodies: Production, Purification, and Applications: Practical Manual, 1989.

  3. Qadri A, Labhasetwar V: Enzyme immunoassay for diagnosis of typhoid fever, In "A Handbook of Practical and Clinical Immunology", Ed. G.P. Talwar and S. K. Gupta, Publisher CBS Publishers & Distributors, New Delhi, 1992.

  4. Levy RJ, Golomb G, Trachy J, Labhasetwar V, Muller D, Topol E: Strategies for treating arterial restenosis using polymeric controlled release implants, In "Biotechnology and Bioactive Polymers", Ed. Gebelein C and Carraher C, Publisher, Plenum Press, New York, 259-268, 1994.

  5. Chen W, Schwendeman S, Labhasetwar V, Levy RJ: Techniques for cardiovascular drug delivery, In "Polymer Site-Specific Pharmacotherapy", Ed. Domb AJ, Publisher, John Wiley & Sons Ltd., 221-241, 1994.

  6. Labhasetwar V, Schwendeman S, Nguyen T, Underwood T, Levy RJ: Iontophoresis for modulating cardiac drug delivery of antiarrhythmic agents, In" Molecular Interventions and Local Drug Delivery in Cardiovascular Disease", Ed. Edelman ER and Levy RJ, Publisher, W.B. Saunders Company Limited, London, UK, 383-398,1995.

  7. Bolling S, Labhasetwar V, Levy RJ: Local immunosuppression of organ transplant, In "Local Immunosuppression of Organ Transplant", Ed, Gruber Scott A, Publisher, R.G. Landes Company, Austin Texas, USA, 161-167, 1996.

  8. Labhasetwar V: Nanoparticles for drug delivery. Pharmaceutical News 4, 28-31, 1997.

  9. Labhasetwar V: Sustained release gene delivery systems: principles and perspectives, In, "Self­ Assembling Complexes for Gene Delivery: From Laboratory to Clinical Trials", Eds. Kabanov,Seymour, Flegner, Publisher, John Wiley & Son, Ltd, UK, 387-399, 1998.

  10. Davda J, De S, Zhou W, Labhasetwar V: Biodegradable nanospheres: therapeutic applications, in “Frontiers in Biomedical and Polymer Science”, (Ed. E. Chiellini), Kluwer-Plenum Publisher, New York, NY,19-33, 2001.

  11. Prabha S, Ma W, Labhasetwar V: Biodegradable nanoparticles as a gene expression vector, in “Polymeric Gene Delivery: Principles and Applications”, (Ed. M. Amiji), CRC Press 357-365, 2004.

  12. Rao K, Panda AK, Labhasetwar V: Intravascular drug delivery systems and devices: interactions at biointerface, in “Surfaces and Interfaces for Biomaterials”, (Ed. Pankaj Vadgama), Woodhead Publishing Limited, Abington, UK. 573-584, 2005.

  13. Leslie-Pelecky D, Labhasetwar V, Kraus Jr. RH: Biomagnetics, in “Advanced Magnetic Nanostructures”, (Eds. D. Sellmyer and R. Skomski), Springer, New York, NY, 461-482, 2006.

  14. Sahoo S, Labhasetwar V: Nanoparticle Interface: An Important determinant in nanoparticle-mediated drug/gene delivery, in "Nanoparticle Technology for Drug Delivery", (Eds. Gupta and Kompella), Mercel Dekker, Inc. New York, NY, 139-160, 2006.

  15. Sahoo S, Jain T, Reddy M, Labhasetwar V: Nano-sized carriers for drug delivery, in "Nanobiotechnology", (Ed. Elan Levy), The Humana Press Inc., Totowa, NJ, 2006 (in press).

  16. Vasir J, Labhasetwar V: Biodegradable nanoparticles, in "DNA Delivery/Gene Transfer Vector Lab Manual", (Eds. Friedmann and Rossi), Cold Spring Harbor Laboratory Press, Woodbury Genome Center, Woodbury, NY, 2006 (in press).

  17. Vasir J, Labhasetwar V: Nanoparticles for Gene Delivery: Formulation Characteristics, in “Nanoparticulate Drug Delivery Systems: Recent Trends and Emerging Technologies”, (Eds Thassu, Deleers, Pathak), CRS Press, 2006 (in press).